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Gene: RWDD2B |
Gene summary for RWDD2B |
Gene summary. |
Gene information | Species | Human | Gene symbol | RWDD2B | Gene ID | 10069 |
Gene name | RWD domain containing 2B | |
Gene Alias | C21orf6 | |
Cytomap | 21q21.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | P57060 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10069 | RWDD2B | LZE24T | Human | Esophagus | ESCC | 9.55e-03 | 6.67e-02 | 0.0596 |
10069 | RWDD2B | P2T-E | Human | Esophagus | ESCC | 1.18e-02 | 8.63e-02 | 0.1177 |
10069 | RWDD2B | P4T-E | Human | Esophagus | ESCC | 2.35e-12 | 2.16e-01 | 0.1323 |
10069 | RWDD2B | P8T-E | Human | Esophagus | ESCC | 1.10e-06 | 8.05e-02 | 0.0889 |
10069 | RWDD2B | P9T-E | Human | Esophagus | ESCC | 7.06e-03 | 1.23e-01 | 0.1131 |
10069 | RWDD2B | P10T-E | Human | Esophagus | ESCC | 3.28e-07 | 1.85e-01 | 0.116 |
10069 | RWDD2B | P12T-E | Human | Esophagus | ESCC | 1.37e-05 | 1.34e-01 | 0.1122 |
10069 | RWDD2B | P16T-E | Human | Esophagus | ESCC | 3.16e-12 | 1.43e-01 | 0.1153 |
10069 | RWDD2B | P19T-E | Human | Esophagus | ESCC | 3.15e-03 | 2.50e-01 | 0.1662 |
10069 | RWDD2B | P21T-E | Human | Esophagus | ESCC | 4.39e-02 | 9.89e-02 | 0.1617 |
10069 | RWDD2B | P22T-E | Human | Esophagus | ESCC | 2.00e-03 | 9.55e-02 | 0.1236 |
10069 | RWDD2B | P23T-E | Human | Esophagus | ESCC | 1.89e-04 | 1.53e-01 | 0.108 |
10069 | RWDD2B | P24T-E | Human | Esophagus | ESCC | 9.22e-07 | 8.03e-02 | 0.1287 |
10069 | RWDD2B | P26T-E | Human | Esophagus | ESCC | 1.74e-05 | 8.52e-02 | 0.1276 |
10069 | RWDD2B | P27T-E | Human | Esophagus | ESCC | 2.65e-04 | 1.20e-01 | 0.1055 |
10069 | RWDD2B | P28T-E | Human | Esophagus | ESCC | 1.19e-07 | 1.61e-01 | 0.1149 |
10069 | RWDD2B | P30T-E | Human | Esophagus | ESCC | 1.56e-10 | 4.06e-01 | 0.137 |
10069 | RWDD2B | P31T-E | Human | Esophagus | ESCC | 1.48e-11 | 1.82e-01 | 0.1251 |
10069 | RWDD2B | P32T-E | Human | Esophagus | ESCC | 2.41e-08 | 1.64e-01 | 0.1666 |
10069 | RWDD2B | P37T-E | Human | Esophagus | ESCC | 3.52e-07 | 2.10e-01 | 0.1371 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RWDD2B | insertion | Frame_Shift_Ins | novel | c.376_377insTGGCT | p.Ser126MetfsTer10 | p.S126Mfs*10 | P57060 | protein_coding | TCGA-IM-A41Z-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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