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Gene: RUNDC1 |
Gene summary for RUNDC1 |
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Gene information | Species | Human | Gene symbol | RUNDC1 | Gene ID | 146923 |
Gene name | RUN domain containing 1 | |
Gene Alias | RUND1 | |
Cytomap | 17q21.31 | |
Gene Type | protein-coding | GO ID | GO:0001701 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
146923 | RUNDC1 | HCC1_Meng | Human | Liver | HCC | 6.82e-13 | -4.34e-02 | 0.0246 |
146923 | RUNDC1 | HCC2_Meng | Human | Liver | HCC | 6.54e-17 | 7.79e-02 | 0.0107 |
146923 | RUNDC1 | HCC1 | Human | Liver | HCC | 7.62e-12 | 3.28e+00 | 0.5336 |
146923 | RUNDC1 | HCC2 | Human | Liver | HCC | 8.49e-23 | 2.80e+00 | 0.5341 |
146923 | RUNDC1 | HCC5 | Human | Liver | HCC | 1.71e-22 | 1.66e+00 | 0.4932 |
146923 | RUNDC1 | S014 | Human | Liver | HCC | 2.10e-03 | 2.56e-01 | 0.2254 |
146923 | RUNDC1 | S015 | Human | Liver | HCC | 4.98e-02 | 2.44e-01 | 0.2375 |
146923 | RUNDC1 | S016 | Human | Liver | HCC | 8.58e-04 | 3.27e-01 | 0.2243 |
146923 | RUNDC1 | S027 | Human | Liver | HCC | 2.78e-02 | 4.26e-01 | 0.2446 |
146923 | RUNDC1 | S028 | Human | Liver | HCC | 4.07e-09 | 5.06e-01 | 0.2503 |
146923 | RUNDC1 | C04 | Human | Oral cavity | OSCC | 6.70e-03 | 2.55e-01 | 0.2633 |
146923 | RUNDC1 | C21 | Human | Oral cavity | OSCC | 4.21e-06 | 2.66e-01 | 0.2678 |
146923 | RUNDC1 | C30 | Human | Oral cavity | OSCC | 1.79e-19 | 6.09e-01 | 0.3055 |
146923 | RUNDC1 | C38 | Human | Oral cavity | OSCC | 8.57e-07 | 6.24e-01 | 0.172 |
146923 | RUNDC1 | C43 | Human | Oral cavity | OSCC | 5.74e-12 | 1.90e-01 | 0.1704 |
146923 | RUNDC1 | C46 | Human | Oral cavity | OSCC | 1.79e-09 | 2.54e-01 | 0.1673 |
146923 | RUNDC1 | C51 | Human | Oral cavity | OSCC | 1.15e-02 | 2.32e-01 | 0.2674 |
146923 | RUNDC1 | C08 | Human | Oral cavity | OSCC | 2.81e-12 | 1.88e-01 | 0.1919 |
146923 | RUNDC1 | LN22 | Human | Oral cavity | OSCC | 2.30e-05 | 5.03e-01 | 0.1733 |
146923 | RUNDC1 | LN46 | Human | Oral cavity | OSCC | 1.13e-04 | 2.46e-01 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000170111 | Liver | HCC | in utero embryonic development | 204/7958 | 367/18723 | 2.44e-07 | 4.30e-06 | 204 |
GO:000170116 | Oral cavity | OSCC | in utero embryonic development | 207/7305 | 367/18723 | 7.92e-12 | 2.95e-10 | 207 |
GO:004308710 | Oral cavity | OSCC | regulation of GTPase activity | 165/7305 | 348/18723 | 7.94e-04 | 4.27e-03 | 165 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RUNDC1 | insertion | Nonsense_Mutation | novel | c.586_587insAATAAAATA | p.Leu196delinsGlnTerAsnMet | p.L196delinsQ*NM | Q96C34 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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