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Gene: RPA1 |
Gene summary for RPA1 |
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Gene information | Species | Human | Gene symbol | RPA1 | Gene ID | 6117 |
Gene name | replication protein A1 | |
Gene Alias | HSSB | |
Cytomap | 17p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P27694 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6117 | RPA1 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.76e-15 | 5.49e-01 | -0.1954 |
6117 | RPA1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.94e-06 | 5.44e-01 | -0.059 |
6117 | RPA1 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.80e-03 | 3.20e-01 | 0.096 |
6117 | RPA1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.17e-04 | 3.96e-01 | 0.294 |
6117 | RPA1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.23e-03 | 4.38e-01 | 0.281 |
6117 | RPA1 | A015-C-203 | Human | Colorectum | FAP | 2.44e-04 | -3.36e-02 | -0.1294 |
6117 | RPA1 | A001-C-108 | Human | Colorectum | FAP | 3.47e-02 | -7.33e-02 | -0.0272 |
6117 | RPA1 | A015-C-104 | Human | Colorectum | FAP | 3.90e-05 | -2.20e-02 | -0.1899 |
6117 | RPA1 | A002-C-116 | Human | Colorectum | FAP | 6.93e-03 | 1.71e-02 | -0.0452 |
6117 | RPA1 | LZE2T | Human | Esophagus | ESCC | 1.65e-03 | 3.61e-01 | 0.082 |
6117 | RPA1 | LZE4T | Human | Esophagus | ESCC | 9.32e-25 | 6.73e-01 | 0.0811 |
6117 | RPA1 | LZE7T | Human | Esophagus | ESCC | 1.43e-08 | 7.18e-01 | 0.0667 |
6117 | RPA1 | LZE8T | Human | Esophagus | ESCC | 1.93e-03 | 1.92e-01 | 0.067 |
6117 | RPA1 | LZE24T | Human | Esophagus | ESCC | 1.80e-18 | 5.30e-01 | 0.0596 |
6117 | RPA1 | LZE21T | Human | Esophagus | ESCC | 1.13e-04 | 2.61e-01 | 0.0655 |
6117 | RPA1 | LZE6T | Human | Esophagus | ESCC | 2.53e-03 | 2.79e-01 | 0.0845 |
6117 | RPA1 | P1T-E | Human | Esophagus | ESCC | 7.99e-05 | 5.38e-01 | 0.0875 |
6117 | RPA1 | P2T-E | Human | Esophagus | ESCC | 1.52e-30 | 6.63e-01 | 0.1177 |
6117 | RPA1 | P4T-E | Human | Esophagus | ESCC | 1.83e-30 | 7.54e-01 | 0.1323 |
6117 | RPA1 | P5T-E | Human | Esophagus | ESCC | 1.02e-05 | 1.57e-01 | 0.1327 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000697914 | Breast | IDC | response to oxidative stress | 83/1434 | 446/18723 | 2.36e-14 | 7.06e-12 | 83 |
GO:000030214 | Breast | IDC | response to reactive oxygen species | 46/1434 | 222/18723 | 4.12e-10 | 4.59e-08 | 46 |
GO:004254213 | Breast | IDC | response to hydrogen peroxide | 32/1434 | 146/18723 | 4.65e-08 | 3.02e-06 | 32 |
GO:000926612 | Breast | IDC | response to temperature stimulus | 34/1434 | 178/18723 | 5.88e-07 | 2.83e-05 | 34 |
GO:005165114 | Breast | IDC | maintenance of location in cell | 37/1434 | 214/18723 | 2.39e-06 | 9.35e-05 | 37 |
GO:005123513 | Breast | IDC | maintenance of location | 48/1434 | 327/18723 | 9.90e-06 | 2.77e-04 | 48 |
GO:000941013 | Breast | IDC | response to xenobiotic stimulus | 62/1434 | 462/18723 | 1.05e-05 | 2.88e-04 | 62 |
GO:000961211 | Breast | IDC | response to mechanical stimulus | 34/1434 | 216/18723 | 4.59e-05 | 1.03e-03 | 34 |
GO:000940912 | Breast | IDC | response to cold | 13/1434 | 49/18723 | 5.70e-05 | 1.20e-03 | 13 |
GO:0000723 | Colorectum | AD | telomere maintenance | 43/3918 | 131/18723 | 9.77e-04 | 9.20e-03 | 43 |
GO:0010833 | Colorectum | AD | telomere maintenance via telomere lengthening | 29/3918 | 81/18723 | 1.42e-03 | 1.22e-02 | 29 |
GO:0071897 | Colorectum | AD | DNA biosynthetic process | 55/3918 | 180/18723 | 1.46e-03 | 1.24e-02 | 55 |
GO:0032392 | Colorectum | AD | DNA geometric change | 31/3918 | 90/18723 | 2.02e-03 | 1.63e-02 | 31 |
GO:0007004 | Colorectum | AD | telomere maintenance via telomerase | 25/3918 | 69/18723 | 2.43e-03 | 1.88e-02 | 25 |
GO:0006278 | Colorectum | AD | RNA-dependent DNA biosynthetic process | 25/3918 | 75/18723 | 8.36e-03 | 4.89e-02 | 25 |
GO:00108332 | Colorectum | MSS | telomere maintenance via telomere lengthening | 28/3467 | 81/18723 | 4.34e-04 | 5.23e-03 | 28 |
GO:00007232 | Colorectum | MSS | telomere maintenance | 40/3467 | 131/18723 | 5.86e-04 | 6.49e-03 | 40 |
GO:00070041 | Colorectum | MSS | telomere maintenance via telomerase | 24/3467 | 69/18723 | 9.79e-04 | 9.84e-03 | 24 |
GO:00323921 | Colorectum | MSS | DNA geometric change | 29/3467 | 90/18723 | 1.26e-03 | 1.20e-02 | 29 |
GO:00718972 | Colorectum | MSS | DNA biosynthetic process | 50/3467 | 180/18723 | 1.45e-03 | 1.35e-02 | 50 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0342022 | Esophagus | ESCC | Nucleotide excision repair | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa030304 | Esophagus | ESCC | DNA replication | 32/4205 | 36/8465 | 7.71e-07 | 5.06e-06 | 2.59e-06 | 32 |
hsa034304 | Esophagus | ESCC | Mismatch repair | 21/4205 | 23/8465 | 2.85e-05 | 1.35e-04 | 6.90e-05 | 21 |
hsa0342032 | Esophagus | ESCC | Nucleotide excision repair | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa0303011 | Esophagus | ESCC | DNA replication | 32/4205 | 36/8465 | 7.71e-07 | 5.06e-06 | 2.59e-06 | 32 |
hsa0343011 | Esophagus | ESCC | Mismatch repair | 21/4205 | 23/8465 | 2.85e-05 | 1.35e-04 | 6.90e-05 | 21 |
hsa03420 | Liver | Cirrhotic | Nucleotide excision repair | 29/2530 | 63/8465 | 4.81e-03 | 1.74e-02 | 1.07e-02 | 29 |
hsa034201 | Liver | Cirrhotic | Nucleotide excision repair | 29/2530 | 63/8465 | 4.81e-03 | 1.74e-02 | 1.07e-02 | 29 |
hsa034202 | Liver | HCC | Nucleotide excision repair | 41/4020 | 63/8465 | 3.59e-03 | 1.12e-02 | 6.22e-03 | 41 |
hsa034203 | Liver | HCC | Nucleotide excision repair | 41/4020 | 63/8465 | 3.59e-03 | 1.12e-02 | 6.22e-03 | 41 |
hsa034204 | Oral cavity | OSCC | Nucleotide excision repair | 49/3704 | 63/8465 | 3.48e-08 | 2.91e-07 | 1.48e-07 | 49 |
hsa03030 | Oral cavity | OSCC | DNA replication | 31/3704 | 36/8465 | 1.70e-07 | 1.19e-06 | 6.03e-07 | 31 |
hsa03430 | Oral cavity | OSCC | Mismatch repair | 19/3704 | 23/8465 | 1.55e-04 | 5.34e-04 | 2.72e-04 | 19 |
hsa0342011 | Oral cavity | OSCC | Nucleotide excision repair | 49/3704 | 63/8465 | 3.48e-08 | 2.91e-07 | 1.48e-07 | 49 |
hsa030301 | Oral cavity | OSCC | DNA replication | 31/3704 | 36/8465 | 1.70e-07 | 1.19e-06 | 6.03e-07 | 31 |
hsa034301 | Oral cavity | OSCC | Mismatch repair | 19/3704 | 23/8465 | 1.55e-04 | 5.34e-04 | 2.72e-04 | 19 |
hsa0342021 | Oral cavity | LP | Nucleotide excision repair | 37/2418 | 63/8465 | 5.14e-07 | 6.33e-06 | 4.08e-06 | 37 |
hsa030302 | Oral cavity | LP | DNA replication | 23/2418 | 36/8465 | 1.08e-05 | 7.79e-05 | 5.02e-05 | 23 |
hsa034302 | Oral cavity | LP | Mismatch repair | 12/2418 | 23/8465 | 1.43e-02 | 4.59e-02 | 2.96e-02 | 12 |
hsa0342031 | Oral cavity | LP | Nucleotide excision repair | 37/2418 | 63/8465 | 5.14e-07 | 6.33e-06 | 4.08e-06 | 37 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPA1 | SNV | Missense_Mutation | c.1442N>T | p.Cys481Phe | p.C481F | P27694 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-J2-8194-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
RPA1 | SNV | Missense_Mutation | c.935N>G | p.Ser312Trp | p.S312W | P27694 | protein_coding | deleterious(0.01) | possibly_damaging(0.651) | TCGA-MP-A4TF-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | navelbine | PD | |
RPA1 | SNV | Missense_Mutation | novel | c.1297N>T | p.Gly433Cys | p.G433C | P27694 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-39-5011-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD |
RPA1 | SNV | Missense_Mutation | c.1507T>C | p.Cys503Arg | p.C503R | P27694 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-66-2800-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
RPA1 | SNV | Missense_Mutation | novel | c.92N>A | p.Arg31His | p.R31H | P27694 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-CN-4734-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RPA1 | SNV | Missense_Mutation | rs777886740 | c.958N>G | p.Ile320Val | p.I320V | P27694 | protein_coding | tolerated(0.12) | benign(0.116) | TCGA-CQ-6219-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
RPA1 | SNV | Missense_Mutation | novel | c.92N>A | p.Arg31His | p.R31H | P27694 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-CR-7374-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPA1 | SNV | Missense_Mutation | novel | c.1096G>A | p.Asp366Asn | p.D366N | P27694 | protein_coding | deleterious(0) | benign(0.091) | TCGA-CV-6936-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
RPA1 | SNV | Missense_Mutation | novel | c.193N>T | p.Leu65Phe | p.L65F | P27694 | protein_coding | tolerated(0.06) | probably_damaging(0.959) | TCGA-CV-A6JM-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
RPA1 | SNV | Missense_Mutation | c.1357N>G | p.Leu453Val | p.L453V | P27694 | protein_coding | deleterious(0) | benign(0.233) | TCGA-HC-7077-01 | Prostate | prostate adenocarcinoma | Male | <65 | 6 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6117 | RPA1 | DNA REPAIR, KINASE | NSC-15520 | CHEMBL1765371 | 21459001 |
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