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Gene: RNF217 |
Gene summary for RNF217 |
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Gene information | Species | Human | Gene symbol | RNF217 | Gene ID | 154214 |
Gene name | ring finger protein 217 | |
Gene Alias | C6orf172 | |
Cytomap | 6q22.31 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | B3KVC8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
154214 | RNF217 | CCI_1 | Human | Cervix | CC | 1.90e-08 | 9.04e-01 | 0.528 |
154214 | RNF217 | CCI_2 | Human | Cervix | CC | 5.98e-10 | 1.31e+00 | 0.5249 |
154214 | RNF217 | CCI_3 | Human | Cervix | CC | 2.29e-08 | 8.47e-01 | 0.516 |
154214 | RNF217 | sample3 | Human | Cervix | CC | 2.24e-05 | 2.41e-01 | 0.1387 |
154214 | RNF217 | T3 | Human | Cervix | CC | 2.00e-05 | 2.48e-01 | 0.1389 |
154214 | RNF217 | LZE4T | Human | Esophagus | ESCC | 9.15e-19 | 7.18e-01 | 0.0811 |
154214 | RNF217 | LZE7T | Human | Esophagus | ESCC | 8.26e-06 | 3.41e-01 | 0.0667 |
154214 | RNF217 | LZE20T | Human | Esophagus | ESCC | 5.09e-03 | 4.77e-02 | 0.0662 |
154214 | RNF217 | LZE24T | Human | Esophagus | ESCC | 4.88e-04 | 5.12e-02 | 0.0596 |
154214 | RNF217 | LZE21T | Human | Esophagus | ESCC | 4.17e-02 | 1.71e-01 | 0.0655 |
154214 | RNF217 | P2T-E | Human | Esophagus | ESCC | 5.14e-11 | 6.89e-02 | 0.1177 |
154214 | RNF217 | P4T-E | Human | Esophagus | ESCC | 5.63e-12 | 1.49e-01 | 0.1323 |
154214 | RNF217 | P5T-E | Human | Esophagus | ESCC | 1.08e-10 | 1.32e-01 | 0.1327 |
154214 | RNF217 | P8T-E | Human | Esophagus | ESCC | 1.73e-08 | 7.36e-02 | 0.0889 |
154214 | RNF217 | P9T-E | Human | Esophagus | ESCC | 1.04e-04 | 1.72e-01 | 0.1131 |
154214 | RNF217 | P10T-E | Human | Esophagus | ESCC | 6.99e-10 | 1.70e-01 | 0.116 |
154214 | RNF217 | P11T-E | Human | Esophagus | ESCC | 1.13e-06 | 1.75e-01 | 0.1426 |
154214 | RNF217 | P12T-E | Human | Esophagus | ESCC | 1.05e-13 | 1.54e-01 | 0.1122 |
154214 | RNF217 | P15T-E | Human | Esophagus | ESCC | 1.05e-12 | 3.61e-01 | 0.1149 |
154214 | RNF217 | P16T-E | Human | Esophagus | ESCC | 9.04e-03 | 2.68e-03 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004217610 | Cervix | CC | regulation of protein catabolic process | 104/2311 | 391/18723 | 9.39e-15 | 9.36e-12 | 104 |
GO:004586210 | Cervix | CC | positive regulation of proteolysis | 95/2311 | 372/18723 | 1.84e-12 | 6.86e-10 | 95 |
GO:190336210 | Cervix | CC | regulation of cellular protein catabolic process | 72/2311 | 255/18723 | 5.98e-12 | 2.10e-09 | 72 |
GO:004573210 | Cervix | CC | positive regulation of protein catabolic process | 65/2311 | 231/18723 | 7.44e-11 | 1.39e-08 | 65 |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:000989610 | Cervix | CC | positive regulation of catabolic process | 109/2311 | 492/18723 | 5.26e-10 | 6.99e-08 | 109 |
GO:190305010 | Cervix | CC | regulation of proteolysis involved in cellular protein catabolic process | 60/2311 | 221/18723 | 1.82e-09 | 1.98e-07 | 60 |
GO:200005810 | Cervix | CC | regulation of ubiquitin-dependent protein catabolic process | 47/2311 | 164/18723 | 1.63e-08 | 1.25e-06 | 47 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:003133110 | Cervix | CC | positive regulation of cellular catabolic process | 91/2311 | 427/18723 | 9.64e-08 | 5.25e-06 | 91 |
GO:00002097 | Cervix | CC | protein polyubiquitination | 58/2311 | 236/18723 | 1.57e-07 | 7.41e-06 | 58 |
GO:190336410 | Cervix | CC | positive regulation of cellular protein catabolic process | 43/2311 | 155/18723 | 1.80e-07 | 8.28e-06 | 43 |
GO:006113610 | Cervix | CC | regulation of proteasomal protein catabolic process | 48/2311 | 187/18723 | 4.63e-07 | 1.77e-05 | 48 |
GO:003243410 | Cervix | CC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 38/2311 | 134/18723 | 4.99e-07 | 1.88e-05 | 38 |
GO:19030528 | Cervix | CC | positive regulation of proteolysis involved in cellular protein catabolic process | 34/2311 | 133/18723 | 2.28e-05 | 4.01e-04 | 34 |
GO:200006010 | Cervix | CC | positive regulation of ubiquitin-dependent protein catabolic process | 29/2311 | 107/18723 | 2.77e-05 | 4.62e-04 | 29 |
GO:00324369 | Cervix | CC | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 25/2311 | 90/18723 | 6.22e-05 | 8.90e-04 | 25 |
GO:19018008 | Cervix | CC | positive regulation of proteasomal protein catabolic process | 29/2311 | 114/18723 | 9.71e-05 | 1.27e-03 | 29 |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNF217 | SNV | Missense_Mutation | novel | c.208G>A | p.Ala70Thr | p.A70T | Q8TC41 | protein_coding | deleterious_low_confidence(0.04) | benign(0.003) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
RNF217 | insertion | Frame_Shift_Ins | novel | c.1587_1588insA | p.Gln532ThrfsTer16 | p.Q532Tfs*16 | Q8TC41 | protein_coding | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
RNF217 | insertion | Frame_Shift_Ins | novel | c.1587_1588insA | p.Gln532ThrfsTer16 | p.Q532Tfs*16 | Q8TC41 | protein_coding | TCGA-VQ-A91X-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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