![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: RHPN1 |
Gene summary for RHPN1 |
![]() |
Gene information | Species | Human | Gene symbol | RHPN1 | Gene ID | 114822 |
Gene name | rhophilin Rho GTPase binding protein 1 | |
Gene Alias | ODF5 | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q8TCX5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114822 | RHPN1 | HCC1_Meng | Human | Liver | HCC | 9.45e-09 | 3.63e-02 | 0.0246 |
114822 | RHPN1 | HCC2_Meng | Human | Liver | HCC | 4.23e-17 | 1.71e-01 | 0.0107 |
114822 | RHPN1 | S014 | Human | Liver | HCC | 1.92e-08 | 3.26e-01 | 0.2254 |
114822 | RHPN1 | S015 | Human | Liver | HCC | 5.21e-17 | 5.92e-01 | 0.2375 |
114822 | RHPN1 | S016 | Human | Liver | HCC | 8.16e-08 | 2.73e-01 | 0.2243 |
114822 | RHPN1 | S027 | Human | Liver | HCC | 9.66e-20 | 8.41e-01 | 0.2446 |
114822 | RHPN1 | S028 | Human | Liver | HCC | 1.69e-33 | 9.02e-01 | 0.2503 |
114822 | RHPN1 | S029 | Human | Liver | HCC | 2.30e-29 | 8.49e-01 | 0.2581 |
114822 | RHPN1 | male-WTA | Human | Thyroid | PTC | 1.22e-05 | 9.03e-02 | 0.1037 |
114822 | RHPN1 | PTC01 | Human | Thyroid | PTC | 1.80e-19 | 3.01e-01 | 0.1899 |
114822 | RHPN1 | PTC03 | Human | Thyroid | PTC | 2.61e-06 | 3.40e-01 | 0.1784 |
114822 | RHPN1 | PTC04 | Human | Thyroid | PTC | 1.71e-15 | 2.80e-01 | 0.1927 |
114822 | RHPN1 | PTC05 | Human | Thyroid | PTC | 1.32e-28 | 8.59e-01 | 0.2065 |
114822 | RHPN1 | PTC06 | Human | Thyroid | PTC | 6.41e-31 | 6.91e-01 | 0.2057 |
114822 | RHPN1 | PTC07 | Human | Thyroid | PTC | 1.41e-32 | 4.92e-01 | 0.2044 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RHPN1 | SNV | Missense_Mutation | c.1650N>C | p.Lys550Asn | p.K550N | Q8TCX5 | protein_coding | deleterious(0) | possibly_damaging(0.687) | TCGA-33-4583-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RHPN1 | SNV | Missense_Mutation | novel | c.752N>A | p.Gly251Glu | p.G251E | Q8TCX5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-33-6738-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | gemcitabine | SD |
RHPN1 | SNV | Missense_Mutation | novel | c.1021A>G | p.Thr341Ala | p.T341A | Q8TCX5 | protein_coding | tolerated(0.61) | benign(0.015) | TCGA-85-8354-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RHPN1 | deletion | In_Frame_Del | novel | c.72_83delNNNNNNNNNNNN | p.Leu25_Ile28del | p.L25_I28del | Q8TCX5 | protein_coding | TCGA-22-5472-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
RHPN1 | SNV | Missense_Mutation | c.2009N>T | p.Pro670Leu | p.P670L | Q8TCX5 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-CV-6936-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
RHPN1 | SNV | Missense_Mutation | rs767448001 | c.1448G>A | p.Arg483His | p.R483H | Q8TCX5 | protein_coding | tolerated(0.05) | benign(0.261) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RHPN1 | SNV | Missense_Mutation | rs764387997 | c.160N>A | p.Ala54Thr | p.A54T | Q8TCX5 | protein_coding | deleterious(0) | possibly_damaging(0.862) | TCGA-BR-4368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RHPN1 | SNV | Missense_Mutation | rs764935123 | c.1367G>A | p.Arg456His | p.R456H | Q8TCX5 | protein_coding | tolerated(0.42) | benign(0.006) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RHPN1 | SNV | Missense_Mutation | rs374426571 | c.1337G>A | p.Arg446His | p.R446H | Q8TCX5 | protein_coding | tolerated(0.12) | benign(0.036) | TCGA-BR-6802-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | CR |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |