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Gene: RGS9 |
Gene summary for RGS9 |
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Gene information | Species | Human | Gene symbol | RGS9 | Gene ID | 8787 |
Gene name | regulator of G protein signaling 9 | |
Gene Alias | PERRS | |
Cytomap | 17q24.1 | |
Gene Type | protein-coding | GO ID | GO:0001975 | UniProtAcc | O75916 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8787 | RGS9 | S015 | Human | Liver | HCC | 5.35e-05 | 1.70e-01 | 0.2375 |
8787 | RGS9 | S027 | Human | Liver | HCC | 1.09e-12 | 9.09e-01 | 0.2446 |
8787 | RGS9 | S028 | Human | Liver | HCC | 1.80e-12 | 4.44e-01 | 0.2503 |
8787 | RGS9 | S029 | Human | Liver | HCC | 1.62e-17 | 7.03e-01 | 0.2581 |
8787 | RGS9 | HTA12-15-2 | Human | Pancreas | PDAC | 5.41e-05 | 5.24e-01 | 0.2315 |
8787 | RGS9 | HTA12-26-1 | Human | Pancreas | PDAC | 1.32e-09 | 5.11e-01 | 0.3728 |
8787 | RGS9 | HTA12-29-1 | Human | Pancreas | PDAC | 2.28e-29 | 6.81e-01 | 0.3722 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007121421 | Liver | HCC | cellular response to abiotic stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
GO:010400421 | Liver | HCC | cellular response to environmental stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
GO:00714782 | Liver | HCC | cellular response to radiation | 104/7958 | 186/18723 | 1.48e-04 | 1.19e-03 | 104 |
GO:00323552 | Liver | HCC | response to estradiol | 81/7958 | 141/18723 | 2.39e-04 | 1.79e-03 | 81 |
GO:00093146 | Liver | HCC | response to radiation | 223/7958 | 456/18723 | 3.08e-03 | 1.43e-02 | 223 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RGS9 | SNV | Missense_Mutation | c.867A>C | p.Glu289Asp | p.E289D | O75916 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
RGS9 | SNV | Missense_Mutation | c.1963N>G | p.Thr655Ala | p.T655A | O75916 | protein_coding | tolerated_low_confidence(0.76) | benign(0) | TCGA-B5-A11V-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RGS9 | SNV | Missense_Mutation | novel | c.1515N>T | p.Lys505Asn | p.K505N | O75916 | protein_coding | tolerated_low_confidence(0.41) | benign(0.014) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RGS9 | SNV | Missense_Mutation | novel | c.1217G>A | p.Arg406His | p.R406H | O75916 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-B5-A1MS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | PD |
RGS9 | SNV | Missense_Mutation | novel | c.1147C>A | p.Pro383Thr | p.P383T | O75916 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
RGS9 | SNV | Missense_Mutation | novel | c.1091G>A | p.Arg364His | p.R364H | O75916 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RGS9 | SNV | Missense_Mutation | novel | c.1639G>T | p.Ala547Ser | p.A547S | O75916 | protein_coding | tolerated_low_confidence(0.97) | benign(0.003) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RGS9 | SNV | Missense_Mutation | novel | c.26N>G | p.Gln9Arg | p.Q9R | protein_coding | tolerated(0.88) | benign(0.132) | TCGA-BG-A221-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RGS9 | SNV | Missense_Mutation | rs755297304 | c.383G>A | p.Arg128Gln | p.R128Q | O75916 | protein_coding | deleterious(0) | possibly_damaging(0.718) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RGS9 | SNV | Missense_Mutation | c.1872N>T | p.Leu624Phe | p.L624F | O75916 | protein_coding | tolerated_low_confidence(0.06) | benign(0.133) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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