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Gene: RCOR1 |
Gene summary for RCOR1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | RCOR1 | Gene ID | 23186 |
Gene name | REST corepressor 1 | |
Gene Alias | COREST | |
Cytomap | 14q32.31-q32.32 | |
Gene Type | protein-coding | GO ID | GO:0002262 | UniProtAcc | Q9UKL0 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23186 | RCOR1 | CCI_1 | Human | Cervix | CC | 3.63e-17 | 1.43e+00 | 0.528 |
23186 | RCOR1 | CCI_2 | Human | Cervix | CC | 1.75e-06 | 8.39e-01 | 0.5249 |
23186 | RCOR1 | CCI_3 | Human | Cervix | CC | 1.26e-10 | 1.11e+00 | 0.516 |
23186 | RCOR1 | sample3 | Human | Cervix | CC | 1.59e-05 | 3.12e-01 | 0.1387 |
23186 | RCOR1 | T3 | Human | Cervix | CC | 1.46e-04 | 3.26e-01 | 0.1389 |
23186 | RCOR1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.66e-17 | -6.26e-01 | 0.0155 |
23186 | RCOR1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.96e-03 | -5.74e-01 | -0.0179 |
23186 | RCOR1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.95e-04 | -4.62e-01 | 0.096 |
23186 | RCOR1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.42e-07 | -4.34e-01 | 0.0674 |
23186 | RCOR1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.72e-09 | -4.56e-01 | 0.294 |
23186 | RCOR1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.77e-18 | -5.88e-01 | 0.3859 |
23186 | RCOR1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 9.40e-09 | -7.56e-01 | 0.2585 |
23186 | RCOR1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.85e-19 | -6.48e-01 | 0.3005 |
23186 | RCOR1 | F007 | Human | Colorectum | FAP | 1.97e-02 | -3.23e-01 | 0.1176 |
23186 | RCOR1 | A002-C-010 | Human | Colorectum | FAP | 6.39e-03 | -3.23e-01 | 0.242 |
23186 | RCOR1 | A001-C-207 | Human | Colorectum | FAP | 6.93e-05 | -3.16e-01 | 0.1278 |
23186 | RCOR1 | A015-C-203 | Human | Colorectum | FAP | 2.12e-28 | -3.84e-01 | -0.1294 |
23186 | RCOR1 | A015-C-204 | Human | Colorectum | FAP | 2.27e-07 | -3.23e-01 | -0.0228 |
23186 | RCOR1 | A014-C-040 | Human | Colorectum | FAP | 1.86e-04 | -3.38e-01 | -0.1184 |
23186 | RCOR1 | A002-C-201 | Human | Colorectum | FAP | 6.38e-13 | -2.96e-01 | 0.0324 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003009910 | Cervix | CC | myeloid cell differentiation | 83/2311 | 381/18723 | 1.31e-07 | 6.42e-06 | 83 |
GO:190370610 | Cervix | CC | regulation of hemopoiesis | 80/2311 | 367/18723 | 2.14e-07 | 9.55e-06 | 80 |
GO:000226210 | Cervix | CC | myeloid cell homeostasis | 43/2311 | 157/18723 | 2.66e-07 | 1.12e-05 | 43 |
GO:003410110 | Cervix | CC | erythrocyte homeostasis | 37/2311 | 129/18723 | 5.16e-07 | 1.93e-05 | 37 |
GO:003021810 | Cervix | CC | erythrocyte differentiation | 34/2311 | 120/18723 | 2.00e-06 | 6.18e-05 | 34 |
GO:004887210 | Cervix | CC | homeostasis of number of cells | 61/2311 | 272/18723 | 2.17e-06 | 6.55e-05 | 61 |
GO:004563710 | Cervix | CC | regulation of myeloid cell differentiation | 48/2311 | 210/18723 | 1.49e-05 | 2.93e-04 | 48 |
GO:00456397 | Cervix | CC | positive regulation of myeloid cell differentiation | 28/2311 | 103/18723 | 3.56e-05 | 5.70e-04 | 28 |
GO:00165705 | Cervix | CC | histone modification | 84/2311 | 463/18723 | 1.70e-04 | 2.01e-03 | 84 |
GO:0034101 | Colorectum | AD | erythrocyte homeostasis | 51/3918 | 129/18723 | 1.07e-06 | 3.59e-05 | 51 |
GO:0030099 | Colorectum | AD | myeloid cell differentiation | 119/3918 | 381/18723 | 1.24e-06 | 4.01e-05 | 119 |
GO:0002262 | Colorectum | AD | myeloid cell homeostasis | 57/3918 | 157/18723 | 6.17e-06 | 1.56e-04 | 57 |
GO:0048872 | Colorectum | AD | homeostasis of number of cells | 87/3918 | 272/18723 | 1.16e-05 | 2.61e-04 | 87 |
GO:0030218 | Colorectum | AD | erythrocyte differentiation | 45/3918 | 120/18723 | 2.22e-05 | 4.39e-04 | 45 |
GO:1903706 | Colorectum | AD | regulation of hemopoiesis | 99/3918 | 367/18723 | 3.08e-03 | 2.28e-02 | 99 |
GO:0045637 | Colorectum | AD | regulation of myeloid cell differentiation | 61/3918 | 210/18723 | 3.17e-03 | 2.35e-02 | 61 |
GO:00341012 | Colorectum | MSS | erythrocyte homeostasis | 49/3467 | 129/18723 | 1.58e-07 | 7.19e-06 | 49 |
GO:00300992 | Colorectum | MSS | myeloid cell differentiation | 110/3467 | 381/18723 | 4.48e-07 | 1.75e-05 | 110 |
GO:00022622 | Colorectum | MSS | myeloid cell homeostasis | 55/3467 | 157/18723 | 6.35e-07 | 2.34e-05 | 55 |
GO:00488722 | Colorectum | MSS | homeostasis of number of cells | 82/3467 | 272/18723 | 2.02e-06 | 6.28e-05 | 82 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501618 | Cervix | CC | Huntington disease | 94/1267 | 306/8465 | 8.49e-13 | 3.06e-11 | 1.81e-11 | 94 |
hsa0501619 | Cervix | CC | Huntington disease | 94/1267 | 306/8465 | 8.49e-13 | 3.06e-11 | 1.81e-11 | 94 |
hsa05016 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa050161 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa050164 | Colorectum | MSS | Huntington disease | 141/1875 | 306/8465 | 2.90e-21 | 1.62e-19 | 9.92e-20 | 141 |
hsa050165 | Colorectum | MSS | Huntington disease | 141/1875 | 306/8465 | 2.90e-21 | 1.62e-19 | 9.92e-20 | 141 |
hsa050168 | Colorectum | FAP | Huntington disease | 73/1404 | 306/8465 | 5.54e-04 | 3.93e-03 | 2.39e-03 | 73 |
hsa050169 | Colorectum | FAP | Huntington disease | 73/1404 | 306/8465 | 5.54e-04 | 3.93e-03 | 2.39e-03 | 73 |
hsa0501620 | Endometrium | AEH | Huntington disease | 118/1197 | 306/8465 | 3.00e-27 | 2.44e-25 | 1.78e-25 | 118 |
hsa05016110 | Endometrium | AEH | Huntington disease | 118/1197 | 306/8465 | 3.00e-27 | 2.44e-25 | 1.78e-25 | 118 |
hsa0501625 | Endometrium | EEC | Huntington disease | 120/1237 | 306/8465 | 3.86e-27 | 4.23e-25 | 3.15e-25 | 120 |
hsa0501635 | Endometrium | EEC | Huntington disease | 120/1237 | 306/8465 | 3.86e-27 | 4.23e-25 | 3.15e-25 | 120 |
hsa05016210 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa0501638 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa0501628 | Oral cavity | OSCC | Huntington disease | 204/3704 | 306/8465 | 1.70e-16 | 7.13e-15 | 3.63e-15 | 204 |
hsa05016112 | Oral cavity | OSCC | Huntington disease | 204/3704 | 306/8465 | 1.70e-16 | 7.13e-15 | 3.63e-15 | 204 |
hsa0501645 | Oral cavity | EOLP | Huntington disease | 69/1218 | 306/8465 | 6.32e-05 | 2.96e-04 | 1.75e-04 | 69 |
hsa0501655 | Oral cavity | EOLP | Huntington disease | 69/1218 | 306/8465 | 6.32e-05 | 2.96e-04 | 1.75e-04 | 69 |
hsa0501612 | Stomach | GC | Huntington disease | 69/708 | 306/8465 | 6.71e-15 | 2.68e-13 | 1.89e-13 | 69 |
hsa0501613 | Stomach | GC | Huntington disease | 69/708 | 306/8465 | 6.71e-15 | 2.68e-13 | 1.89e-13 | 69 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RCOR1 | SNV | Missense_Mutation | novel | c.502N>G | p.Leu168Val | p.L168V | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CV-A6K2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
RCOR1 | SNV | Missense_Mutation | rs753513724 | c.716N>T | p.Thr239Met | p.T239M | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-BR-6566-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RCOR1 | SNV | Missense_Mutation | rs769850312 | c.770N>A | p.Arg257Gln | p.R257Q | protein_coding | tolerated(0.53) | probably_damaging(0.998) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RCOR1 | SNV | Missense_Mutation | rs555509094 | c.377N>A | p.Arg126His | p.R126H | protein_coding | tolerated(0.38) | possibly_damaging(0.454) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
RCOR1 | SNV | Missense_Mutation | c.190N>C | p.Ala64Pro | p.A64P | protein_coding | tolerated_low_confidence(0.3) | unknown(0) | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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