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Gene: RCBTB2 |
Gene summary for RCBTB2 |
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Gene information | Species | Human | Gene symbol | RCBTB2 | Gene ID | 1102 |
Gene name | RCC1 and BTB domain containing protein 2 | |
Gene Alias | CHC1L | |
Cytomap | 13q14.2 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | O95199 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1102 | RCBTB2 | LZE8T | Human | Esophagus | ESCC | 1.33e-02 | 4.88e-02 | 0.067 |
1102 | RCBTB2 | P2T-E | Human | Esophagus | ESCC | 6.91e-12 | 1.14e-01 | 0.1177 |
1102 | RCBTB2 | P5T-E | Human | Esophagus | ESCC | 1.56e-03 | -2.11e-02 | 0.1327 |
1102 | RCBTB2 | P8T-E | Human | Esophagus | ESCC | 3.16e-10 | 1.85e-01 | 0.0889 |
1102 | RCBTB2 | P9T-E | Human | Esophagus | ESCC | 1.13e-06 | 7.16e-02 | 0.1131 |
1102 | RCBTB2 | P10T-E | Human | Esophagus | ESCC | 6.91e-08 | 1.17e-01 | 0.116 |
1102 | RCBTB2 | P12T-E | Human | Esophagus | ESCC | 1.15e-04 | 5.25e-02 | 0.1122 |
1102 | RCBTB2 | P17T-E | Human | Esophagus | ESCC | 2.80e-02 | 2.15e-01 | 0.1278 |
1102 | RCBTB2 | P20T-E | Human | Esophagus | ESCC | 5.09e-06 | 2.74e-01 | 0.1124 |
1102 | RCBTB2 | P23T-E | Human | Esophagus | ESCC | 3.21e-08 | 2.26e-01 | 0.108 |
1102 | RCBTB2 | P24T-E | Human | Esophagus | ESCC | 8.75e-07 | 9.15e-02 | 0.1287 |
1102 | RCBTB2 | P27T-E | Human | Esophagus | ESCC | 1.15e-07 | 8.91e-02 | 0.1055 |
1102 | RCBTB2 | P28T-E | Human | Esophagus | ESCC | 3.99e-02 | 3.20e-02 | 0.1149 |
1102 | RCBTB2 | P30T-E | Human | Esophagus | ESCC | 2.89e-10 | 3.99e-01 | 0.137 |
1102 | RCBTB2 | P32T-E | Human | Esophagus | ESCC | 4.42e-07 | 5.07e-02 | 0.1666 |
1102 | RCBTB2 | P36T-E | Human | Esophagus | ESCC | 5.59e-03 | 2.45e-01 | 0.1187 |
1102 | RCBTB2 | P37T-E | Human | Esophagus | ESCC | 4.44e-02 | 4.47e-02 | 0.1371 |
1102 | RCBTB2 | P40T-E | Human | Esophagus | ESCC | 7.34e-03 | 3.66e-02 | 0.109 |
1102 | RCBTB2 | P42T-E | Human | Esophagus | ESCC | 3.91e-05 | 1.98e-01 | 0.1175 |
1102 | RCBTB2 | P44T-E | Human | Esophagus | ESCC | 9.43e-06 | 1.64e-01 | 0.1096 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RCBTB2 | SNV | Missense_Mutation | rs560160674 | c.862N>A | p.Ala288Thr | p.A288T | protein_coding | deleterious(0.04) | probably_damaging(0.97) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RCBTB2 | SNV | Missense_Mutation | rs374478911 | c.602N>A | p.Arg201Gln | p.R201Q | protein_coding | tolerated(0.12) | possibly_damaging(0.861) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response | |
RCBTB2 | SNV | Missense_Mutation | rs374478911 | c.602G>A | p.Arg201Gln | p.R201Q | protein_coding | tolerated(0.12) | possibly_damaging(0.861) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
RCBTB2 | SNV | Missense_Mutation | novel | c.1065C>A | p.Phe355Leu | p.F355L | protein_coding | tolerated(0.12) | benign(0.007) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RCBTB2 | SNV | Missense_Mutation | rs771974782 | c.1105N>A | p.Ala369Thr | p.A369T | protein_coding | tolerated(0.22) | benign(0.217) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD | |
RCBTB2 | SNV | Missense_Mutation | novel | c.692N>A | p.Val231Asp | p.V231D | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-PG-A915-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RCBTB2 | insertion | Frame_Shift_Ins | novel | c.118_119insT | p.Ser40PhefsTer5 | p.S40Ffs*5 | protein_coding | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
RCBTB2 | deletion | Frame_Shift_Del | c.313delA | p.Ile105Ter | p.I105* | protein_coding | TCGA-B5-A0K9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||||
RCBTB2 | deletion | Frame_Shift_Del | c.313delN | p.Ile105Ter | p.I105* | protein_coding | TCGA-EO-A22T-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||||
RCBTB2 | deletion | Frame_Shift_Del | c.313delN | p.Ile105Ter | p.I105* | protein_coding | TCGA-EY-A1GF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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