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Gene: RANBP3 |
Gene summary for RANBP3 |
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Gene information | Species | Human | Gene symbol | RANBP3 | Gene ID | 8498 |
Gene name | RAN binding protein 3 | |
Gene Alias | RANBP3 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006611 | UniProtAcc | B7Z7F3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8498 | RANBP3 | LZE4T | Human | Esophagus | ESCC | 1.05e-11 | 2.36e-01 | 0.0811 |
8498 | RANBP3 | LZE7T | Human | Esophagus | ESCC | 9.20e-15 | 5.83e-01 | 0.0667 |
8498 | RANBP3 | LZE8T | Human | Esophagus | ESCC | 2.41e-12 | 2.64e-01 | 0.067 |
8498 | RANBP3 | LZE20T | Human | Esophagus | ESCC | 1.87e-02 | 4.45e-02 | 0.0662 |
8498 | RANBP3 | LZE21D1 | Human | Esophagus | HGIN | 1.45e-03 | 2.00e-01 | 0.0632 |
8498 | RANBP3 | LZE22T | Human | Esophagus | ESCC | 2.41e-05 | 2.17e-01 | 0.068 |
8498 | RANBP3 | LZE24T | Human | Esophagus | ESCC | 6.60e-16 | 3.64e-01 | 0.0596 |
8498 | RANBP3 | LZE21T | Human | Esophagus | ESCC | 5.54e-08 | 2.36e-01 | 0.0655 |
8498 | RANBP3 | LZE6T | Human | Esophagus | ESCC | 5.48e-05 | 2.03e-01 | 0.0845 |
8498 | RANBP3 | P1T-E | Human | Esophagus | ESCC | 1.10e-06 | 3.52e-01 | 0.0875 |
8498 | RANBP3 | P2T-E | Human | Esophagus | ESCC | 1.70e-14 | 2.80e-01 | 0.1177 |
8498 | RANBP3 | P4T-E | Human | Esophagus | ESCC | 3.97e-17 | 3.57e-01 | 0.1323 |
8498 | RANBP3 | P5T-E | Human | Esophagus | ESCC | 7.16e-16 | 2.71e-01 | 0.1327 |
8498 | RANBP3 | P8T-E | Human | Esophagus | ESCC | 2.86e-20 | 4.27e-01 | 0.0889 |
8498 | RANBP3 | P9T-E | Human | Esophagus | ESCC | 5.53e-21 | 4.16e-01 | 0.1131 |
8498 | RANBP3 | P10T-E | Human | Esophagus | ESCC | 9.04e-21 | 4.36e-01 | 0.116 |
8498 | RANBP3 | P11T-E | Human | Esophagus | ESCC | 1.18e-18 | 4.63e-01 | 0.1426 |
8498 | RANBP3 | P12T-E | Human | Esophagus | ESCC | 2.71e-21 | 4.26e-01 | 0.1122 |
8498 | RANBP3 | P15T-E | Human | Esophagus | ESCC | 1.11e-12 | 2.88e-01 | 0.1149 |
8498 | RANBP3 | P16T-E | Human | Esophagus | ESCC | 5.07e-25 | 2.94e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000691319 | Esophagus | HGIN | nucleocytoplasmic transport | 83/2587 | 301/18723 | 2.14e-10 | 1.97e-08 | 83 |
GO:005116919 | Esophagus | HGIN | nuclear transport | 83/2587 | 301/18723 | 2.14e-10 | 1.97e-08 | 83 |
GO:005116819 | Esophagus | HGIN | nuclear export | 48/2587 | 154/18723 | 2.21e-08 | 1.34e-06 | 48 |
GO:000661110 | Esophagus | HGIN | protein export from nucleus | 22/2587 | 57/18723 | 2.96e-06 | 1.02e-04 | 22 |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051168110 | Esophagus | ESCC | nuclear export | 126/8552 | 154/18723 | 1.88e-20 | 2.65e-18 | 126 |
GO:000661117 | Esophagus | ESCC | protein export from nucleus | 48/8552 | 57/18723 | 1.92e-09 | 4.39e-08 | 48 |
GO:000691317 | Oral cavity | OSCC | nucleocytoplasmic transport | 204/7305 | 301/18723 | 2.65e-24 | 6.98e-22 | 204 |
GO:005116917 | Oral cavity | OSCC | nuclear transport | 204/7305 | 301/18723 | 2.65e-24 | 6.98e-22 | 204 |
GO:005116817 | Oral cavity | OSCC | nuclear export | 112/7305 | 154/18723 | 1.70e-17 | 1.56e-15 | 112 |
GO:00066119 | Oral cavity | OSCC | protein export from nucleus | 42/7305 | 57/18723 | 1.10e-07 | 1.87e-06 | 42 |
GO:000691324 | Skin | cSCC | nucleocytoplasmic transport | 162/4864 | 301/18723 | 4.20e-25 | 1.10e-22 | 162 |
GO:005116924 | Skin | cSCC | nuclear transport | 162/4864 | 301/18723 | 4.20e-25 | 1.10e-22 | 162 |
GO:0051168111 | Skin | cSCC | nuclear export | 91/4864 | 154/18723 | 3.33e-18 | 4.18e-16 | 91 |
GO:000661119 | Skin | cSCC | protein export from nucleus | 34/4864 | 57/18723 | 8.07e-08 | 1.96e-06 | 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0516639 | Esophagus | HGIN | Human T-cell leukemia virus 1 infection | 51/1383 | 222/8465 | 5.84e-03 | 4.05e-02 | 3.22e-02 | 51 |
hsa05166114 | Esophagus | HGIN | Human T-cell leukemia virus 1 infection | 51/1383 | 222/8465 | 5.84e-03 | 4.05e-02 | 3.22e-02 | 51 |
hsa05166211 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa05166310 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa0516630 | Oral cavity | OSCC | Human T-cell leukemia virus 1 infection | 150/3704 | 222/8465 | 3.68e-13 | 7.26e-12 | 3.70e-12 | 150 |
hsa05166113 | Oral cavity | OSCC | Human T-cell leukemia virus 1 infection | 150/3704 | 222/8465 | 3.68e-13 | 7.26e-12 | 3.70e-12 | 150 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RANBP3 | SNV | Missense_Mutation | novel | c.1346N>A | p.Gly449Glu | p.G449E | Q9H6Z4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-05-4405-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RANBP3 | SNV | Missense_Mutation | rs771487208 | c.428N>A | p.Arg143Gln | p.R143Q | Q9H6Z4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-38-4631-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RANBP3 | SNV | Missense_Mutation | rs183601024 | c.1603N>A | p.Glu535Lys | p.E535K | Q9H6Z4 | protein_coding | tolerated(0.15) | benign(0.207) | TCGA-91-6831-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RANBP3 | SNV | Missense_Mutation | rs750943746 | c.1453N>A | p.Val485Met | p.V485M | Q9H6Z4 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-MP-A4TF-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | navelbine | PD |
RANBP3 | SNV | Missense_Mutation | rs776798051 | c.1621G>A | p.Asp541Asn | p.D541N | Q9H6Z4 | protein_coding | deleterious(0.05) | possibly_damaging(0.627) | TCGA-85-8582-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RANBP3 | SNV | Missense_Mutation | novel | c.1080N>C | p.Gln360His | p.Q360H | Q9H6Z4 | protein_coding | tolerated(0.07) | possibly_damaging(0.838) | TCGA-98-A53J-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RANBP3 | SNV | Missense_Mutation | c.883G>A | p.Ala295Thr | p.A295T | Q9H6Z4 | protein_coding | deleterious(0.04) | benign(0.326) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | |
RANBP3 | SNV | Missense_Mutation | c.1520G>A | p.Arg507His | p.R507H | Q9H6Z4 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
RANBP3 | SNV | Missense_Mutation | c.1682G>A | p.Gly561Glu | p.G561E | Q9H6Z4 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.922) | TCGA-CD-A487-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | epirubicin | CR | |
RANBP3 | SNV | Missense_Mutation | rs761605718 | c.295N>A | p.Gly99Ser | p.G99S | Q9H6Z4 | protein_coding | tolerated_low_confidence(0.08) | benign(0.069) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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