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Gene: RALBP1 |
Gene summary for RALBP1 |
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Gene information | Species | Human | Gene symbol | RALBP1 | Gene ID | 10928 |
Gene name | ralA binding protein 1 | |
Gene Alias | RIP1 | |
Cytomap | 18p11.22 | |
Gene Type | protein-coding | GO ID | GO:0000266 | UniProtAcc | Q15311 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10928 | RALBP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.03e-20 | 6.11e-01 | -0.1954 |
10928 | RALBP1 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.72e-03 | 3.30e-01 | -0.0842 |
10928 | RALBP1 | A015-C-203 | Human | Colorectum | FAP | 4.46e-11 | -6.76e-02 | -0.1294 |
10928 | RALBP1 | A001-C-108 | Human | Colorectum | FAP | 2.63e-05 | 4.60e-02 | -0.0272 |
10928 | RALBP1 | A002-C-205 | Human | Colorectum | FAP | 2.87e-02 | -3.66e-02 | -0.1236 |
10928 | RALBP1 | A015-C-104 | Human | Colorectum | FAP | 2.17e-13 | 5.58e-02 | -0.1899 |
10928 | RALBP1 | A001-C-014 | Human | Colorectum | FAP | 3.59e-03 | -2.55e-02 | 0.0135 |
10928 | RALBP1 | A002-C-016 | Human | Colorectum | FAP | 1.75e-05 | -4.33e-02 | 0.0521 |
10928 | RALBP1 | A002-C-116 | Human | Colorectum | FAP | 4.43e-14 | -1.27e-01 | -0.0452 |
10928 | RALBP1 | F034 | Human | Colorectum | FAP | 1.06e-07 | 6.95e-02 | -0.0665 |
10928 | RALBP1 | F072B | Human | Colorectum | FAP | 4.68e-02 | -2.99e-02 | 0.257 |
10928 | RALBP1 | CRC-1-8810 | Human | Colorectum | CRC | 3.58e-03 | -1.76e-01 | 0.6257 |
10928 | RALBP1 | CRC-3-11773 | Human | Colorectum | CRC | 4.58e-02 | -1.24e-01 | 0.2564 |
10928 | RALBP1 | LZE2T | Human | Esophagus | ESCC | 3.23e-07 | 1.44e+00 | 0.082 |
10928 | RALBP1 | LZE4T | Human | Esophagus | ESCC | 3.97e-10 | 2.37e-01 | 0.0811 |
10928 | RALBP1 | LZE7T | Human | Esophagus | ESCC | 2.38e-06 | 5.00e-01 | 0.0667 |
10928 | RALBP1 | LZE8T | Human | Esophagus | ESCC | 8.64e-06 | 1.49e-01 | 0.067 |
10928 | RALBP1 | LZE20T | Human | Esophagus | ESCC | 2.64e-11 | 3.48e-01 | 0.0662 |
10928 | RALBP1 | LZE22D1 | Human | Esophagus | HGIN | 2.83e-04 | 1.73e-01 | 0.0595 |
10928 | RALBP1 | LZE24T | Human | Esophagus | ESCC | 1.22e-23 | 9.34e-01 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010821 | Colorectum | AD | regulation of mitochondrion organization | 57/3918 | 144/18723 | 2.43e-07 | 9.92e-06 | 57 |
GO:0009636 | Colorectum | AD | response to toxic substance | 88/3918 | 262/18723 | 1.12e-06 | 3.72e-05 | 88 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0007265 | Colorectum | AD | Ras protein signal transduction | 104/3918 | 337/18723 | 1.01e-05 | 2.35e-04 | 104 |
GO:0010822 | Colorectum | AD | positive regulation of mitochondrion organization | 32/3918 | 74/18723 | 1.22e-05 | 2.68e-04 | 32 |
GO:0051056 | Colorectum | AD | regulation of small GTPase mediated signal transduction | 94/3918 | 302/18723 | 1.81e-05 | 3.76e-04 | 94 |
GO:0098754 | Colorectum | AD | detoxification | 53/3918 | 152/18723 | 4.63e-05 | 7.98e-04 | 53 |
GO:0043547 | Colorectum | AD | positive regulation of GTPase activity | 75/3918 | 255/18723 | 7.95e-04 | 7.91e-03 | 75 |
GO:0046578 | Colorectum | AD | regulation of Ras protein signal transduction | 56/3918 | 189/18723 | 2.85e-03 | 2.14e-02 | 56 |
GO:0007266 | Colorectum | AD | Rho protein signal transduction | 42/3918 | 137/18723 | 4.64e-03 | 3.16e-02 | 42 |
GO:00510562 | Colorectum | FAP | regulation of small GTPase mediated signal transduction | 78/2622 | 302/18723 | 3.25e-08 | 2.85e-06 | 78 |
GO:00430873 | Colorectum | FAP | regulation of GTPase activity | 85/2622 | 348/18723 | 1.20e-07 | 7.68e-06 | 85 |
GO:00072652 | Colorectum | FAP | Ras protein signal transduction | 80/2622 | 337/18723 | 9.61e-07 | 4.33e-05 | 80 |
GO:00435472 | Colorectum | FAP | positive regulation of GTPase activity | 61/2622 | 255/18723 | 1.39e-05 | 3.73e-04 | 61 |
GO:00465781 | Colorectum | FAP | regulation of Ras protein signal transduction | 47/2622 | 189/18723 | 4.67e-05 | 9.60e-04 | 47 |
GO:00072661 | Colorectum | FAP | Rho protein signal transduction | 34/2622 | 137/18723 | 5.11e-04 | 5.82e-03 | 34 |
GO:00108213 | Colorectum | FAP | regulation of mitochondrion organization | 35/2622 | 144/18723 | 6.44e-04 | 7.05e-03 | 35 |
GO:0035023 | Colorectum | FAP | regulation of Rho protein signal transduction | 22/2622 | 86/18723 | 3.11e-03 | 2.33e-02 | 22 |
GO:00096363 | Colorectum | FAP | response to toxic substance | 53/2622 | 262/18723 | 3.35e-03 | 2.46e-02 | 53 |
GO:00510563 | Colorectum | CRC | regulation of small GTPase mediated signal transduction | 69/2078 | 302/18723 | 3.34e-09 | 9.08e-07 | 69 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05212 | Colorectum | AD | Pancreatic cancer | 29/2092 | 76/8465 | 6.25e-03 | 2.68e-02 | 1.71e-02 | 29 |
hsa052121 | Colorectum | AD | Pancreatic cancer | 29/2092 | 76/8465 | 6.25e-03 | 2.68e-02 | 1.71e-02 | 29 |
hsa052124 | Colorectum | FAP | Pancreatic cancer | 24/1404 | 76/8465 | 8.95e-04 | 5.20e-03 | 3.16e-03 | 24 |
hsa052125 | Colorectum | FAP | Pancreatic cancer | 24/1404 | 76/8465 | 8.95e-04 | 5.20e-03 | 3.16e-03 | 24 |
hsa04014 | Colorectum | CRC | Ras signaling pathway | 49/1091 | 236/8465 | 4.04e-04 | 4.50e-03 | 3.05e-03 | 49 |
hsa040141 | Colorectum | CRC | Ras signaling pathway | 49/1091 | 236/8465 | 4.04e-04 | 4.50e-03 | 3.05e-03 | 49 |
hsa0521216 | Esophagus | ESCC | Pancreatic cancer | 62/4205 | 76/8465 | 7.37e-09 | 6.85e-08 | 3.51e-08 | 62 |
hsa0521217 | Esophagus | ESCC | Pancreatic cancer | 62/4205 | 76/8465 | 7.37e-09 | 6.85e-08 | 3.51e-08 | 62 |
hsa052126 | Liver | Cirrhotic | Pancreatic cancer | 34/2530 | 76/8465 | 4.20e-03 | 1.63e-02 | 1.00e-02 | 34 |
hsa0521211 | Liver | Cirrhotic | Pancreatic cancer | 34/2530 | 76/8465 | 4.20e-03 | 1.63e-02 | 1.00e-02 | 34 |
hsa0521221 | Liver | HCC | Pancreatic cancer | 54/4020 | 76/8465 | 2.50e-05 | 1.64e-04 | 9.12e-05 | 54 |
hsa0521231 | Liver | HCC | Pancreatic cancer | 54/4020 | 76/8465 | 2.50e-05 | 1.64e-04 | 9.12e-05 | 54 |
hsa0521210 | Oral cavity | OSCC | Pancreatic cancer | 60/3704 | 76/8465 | 3.32e-10 | 4.45e-09 | 2.26e-09 | 60 |
hsa0521215 | Oral cavity | OSCC | Pancreatic cancer | 60/3704 | 76/8465 | 3.32e-10 | 4.45e-09 | 2.26e-09 | 60 |
hsa0521223 | Oral cavity | LP | Pancreatic cancer | 40/2418 | 76/8465 | 8.08e-06 | 6.11e-05 | 3.94e-05 | 40 |
hsa0521233 | Oral cavity | LP | Pancreatic cancer | 40/2418 | 76/8465 | 8.08e-06 | 6.11e-05 | 3.94e-05 | 40 |
hsa052129 | Prostate | BPH | Pancreatic cancer | 31/1718 | 76/8465 | 3.36e-05 | 2.47e-04 | 1.53e-04 | 31 |
hsa0521214 | Prostate | BPH | Pancreatic cancer | 31/1718 | 76/8465 | 3.36e-05 | 2.47e-04 | 1.53e-04 | 31 |
hsa0521222 | Prostate | Tumor | Pancreatic cancer | 33/1791 | 76/8465 | 9.72e-06 | 8.05e-05 | 4.99e-05 | 33 |
hsa0521232 | Prostate | Tumor | Pancreatic cancer | 33/1791 | 76/8465 | 9.72e-06 | 8.05e-05 | 4.99e-05 | 33 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RALBP1 | SNV | Missense_Mutation | rs751698054 | c.634N>A | p.Val212Ile | p.V212I | Q15311 | protein_coding | tolerated(0.31) | benign(0.049) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
RALBP1 | SNV | Missense_Mutation | rs777454415 | c.1241N>A | p.Arg414Gln | p.R414Q | Q15311 | protein_coding | tolerated(0.32) | benign(0.007) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
RALBP1 | SNV | Missense_Mutation | novel | c.1295N>C | p.Val432Ala | p.V432A | Q15311 | protein_coding | deleterious(0.02) | probably_damaging(0.99) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RALBP1 | SNV | Missense_Mutation | novel | c.1458N>T | p.Glu486Asp | p.E486D | Q15311 | protein_coding | tolerated(0.1) | benign(0.194) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RALBP1 | SNV | Missense_Mutation | novel | c.1301N>T | p.Arg434Ile | p.R434I | Q15311 | protein_coding | deleterious(0.03) | benign(0.105) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
RALBP1 | SNV | Missense_Mutation | novel | c.977A>G | p.Asp326Gly | p.D326G | Q15311 | protein_coding | deleterious(0.05) | possibly_damaging(0.893) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
RALBP1 | SNV | Missense_Mutation | novel | c.1712A>C | p.Asn571Thr | p.N571T | Q15311 | protein_coding | tolerated(0.44) | benign(0.001) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
RALBP1 | SNV | Missense_Mutation | novel | c.1744N>A | p.Glu582Lys | p.E582K | Q15311 | protein_coding | tolerated(0.05) | benign(0.111) | TCGA-DD-AACB-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RALBP1 | SNV | Missense_Mutation | novel | c.283G>A | p.Asp95Asn | p.D95N | Q15311 | protein_coding | deleterious(0) | possibly_damaging(0.627) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RALBP1 | SNV | Missense_Mutation | c.1623G>T | p.Glu541Asp | p.E541D | Q15311 | protein_coding | tolerated(1) | benign(0) | TCGA-64-5775-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10928 | RALBP1 | TRANSPORTER, ABC TRANSPORTER | carbamazepine | CARBAMAZEPINE | 21738081 | |
10928 | RALBP1 | TRANSPORTER, ABC TRANSPORTER | DOX | 12632060 | ||
10928 | RALBP1 | TRANSPORTER, ABC TRANSPORTER | vincristine | VINCRISTINE | 27180762 |
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