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Gene: RAD18 |
Gene summary for RAD18 |
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Gene information | Species | Human | Gene symbol | RAD18 | Gene ID | 56852 |
Gene name | RAD18 E3 ubiquitin protein ligase | |
Gene Alias | RNF73 | |
Cytomap | 3p25.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9NS91 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56852 | RAD18 | CCI_2 | Human | Cervix | CC | 9.84e-06 | 5.21e-01 | 0.5249 |
56852 | RAD18 | CCI_3 | Human | Cervix | CC | 1.22e-09 | 6.55e-01 | 0.516 |
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Tissue | Expression Dynamics | Abbreviation |
Cervix | ![]() | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
N_HPV: HPV-infected normal cervix |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00518656 | Cervix | CC | protein autoubiquitination | 17/2311 | 73/18723 | 6.71e-03 | 3.70e-02 | 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RAD18 | insertion | In_Frame_Ins | novel | c.1073_1074insCCAACATGGTGAAACCCTATCTCTACT | p.Arg358delinsSerGlnHisGlyGluThrLeuSerLeuLeu | p.R358delinsSQHGETLSLL | Q9NS91 | protein_coding | TCGA-D1-A0ZR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RAD18 | insertion | Frame_Shift_Ins | novel | c.984_985insATATACACGAA | p.Asp329IlefsTer11 | p.D329Ifs*11 | Q9NS91 | protein_coding | TCGA-D1-A0ZR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RAD18 | insertion | Frame_Shift_Ins | rs34098429 | c.978_979insT | p.Thr327TyrfsTer11 | p.T327Yfs*11 | Q9NS91 | protein_coding | TCGA-D1-A163-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | SD | ||
RAD18 | SNV | Missense_Mutation | c.755C>G | p.Ser252Cys | p.S252C | Q9NS91 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-67-4679-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RAD18 | SNV | Missense_Mutation | c.868N>C | p.Asp290His | p.D290H | Q9NS91 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-78-7150-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD | |
RAD18 | SNV | Missense_Mutation | c.1331N>T | p.Ser444Leu | p.S444L | Q9NS91 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-34-2605-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
RAD18 | SNV | Missense_Mutation | novel | c.1441G>T | p.Ala481Ser | p.A481S | Q9NS91 | protein_coding | tolerated(0.41) | benign(0) | TCGA-34-2609-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | gemcitabine | PD |
RAD18 | SNV | Missense_Mutation | novel | c.1043N>T | p.Ser348Ile | p.S348I | Q9NS91 | protein_coding | deleterious(0.01) | possibly_damaging(0.534) | TCGA-CN-5363-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
RAD18 | SNV | Missense_Mutation | rs369225742 | c.937C>T | p.Arg313Cys | p.R313C | Q9NS91 | protein_coding | deleterious(0) | possibly_damaging(0.893) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RAD18 | SNV | Missense_Mutation | novel | c.1139C>G | p.Ser380Cys | p.S380C | Q9NS91 | protein_coding | deleterious(0.05) | benign(0.415) | TCGA-QK-A6II-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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