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Gene: PRUNE2 |
Gene summary for PRUNE2 |
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Gene information | Species | Human | Gene symbol | PRUNE2 | Gene ID | 158471 |
Gene name | prune homolog 2 with BCH domain | |
Gene Alias | BMCC1 | |
Cytomap | 9q21.2 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | A0A088AWP5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
158471 | PRUNE2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.90e-27 | 1.26e+00 | -0.0811 |
158471 | PRUNE2 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.52e-22 | 1.08e+00 | -0.1088 |
158471 | PRUNE2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.39e-11 | 6.78e-01 | -0.1954 |
158471 | PRUNE2 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.77e-02 | 5.43e-01 | -0.1464 |
158471 | PRUNE2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.65e-08 | 8.04e-01 | -0.1001 |
158471 | PRUNE2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.36e-05 | 6.37e-01 | -0.059 |
158471 | PRUNE2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 6.85e-03 | 6.13e-01 | 0.0446 |
158471 | PRUNE2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.58e-03 | 4.63e-01 | 0.0338 |
158471 | PRUNE2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.28e-22 | 1.21e+00 | 0.0588 |
158471 | PRUNE2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.74e-26 | 9.75e-01 | 0.294 |
158471 | PRUNE2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 9.62e-07 | 1.43e+00 | 0.3487 |
158471 | PRUNE2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.58e-27 | 1.86e+00 | 0.281 |
158471 | PRUNE2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.38e-21 | 1.17e+00 | 0.3859 |
158471 | PRUNE2 | A002-C-010 | Human | Colorectum | FAP | 1.49e-07 | 5.51e-01 | 0.242 |
158471 | PRUNE2 | A001-C-207 | Human | Colorectum | FAP | 1.61e-07 | 5.91e-01 | 0.1278 |
158471 | PRUNE2 | A015-C-203 | Human | Colorectum | FAP | 5.80e-05 | 1.69e-01 | -0.1294 |
158471 | PRUNE2 | A002-C-201 | Human | Colorectum | FAP | 1.89e-05 | 3.88e-01 | 0.0324 |
158471 | PRUNE2 | A002-C-203 | Human | Colorectum | FAP | 3.36e-18 | 7.92e-01 | 0.2786 |
158471 | PRUNE2 | A001-C-108 | Human | Colorectum | FAP | 3.00e-07 | 4.45e-01 | -0.0272 |
158471 | PRUNE2 | A002-C-021 | Human | Colorectum | FAP | 2.15e-11 | 5.42e-01 | 0.1171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRUNE2 | insertion | Frame_Shift_Ins | novel | c.6463_6464insTAGGGAAGCAAGATATCTGCTCATCTGAAGCCTCGTGGGGT | p.Pro2155LeufsTer37 | p.P2155Lfs*37 | Q8WUY3 | protein_coding | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
PRUNE2 | insertion | In_Frame_Ins | novel | c.6088_6089insCAACAGTACAGGTTTACAAGTATCAGAAAAAGG | p.Lys2030delinsThrThrValGlnValTyrLysTyrGlnLysLysGlu | p.K2030delinsTTVQVYKYQKKE | Q8WUY3 | protein_coding | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | ||
PRUNE2 | insertion | In_Frame_Ins | novel | c.6985_6986insAAGGAT | p.Pro2329delinsGlnGlySer | p.P2329delinsQGS | Q8WUY3 | protein_coding | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PRUNE2 | insertion | In_Frame_Ins | novel | c.6984_6985insATAAAAAATATTAAATTACCTCTTTTAGATGATCATTTG | p.His2328_Pro2329insIleLysAsnIleLysLeuProLeuLeuAspAspHisLeu | p.H2328_P2329insIKNIKLPLLDDHL | Q8WUY3 | protein_coding | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PRUNE2 | insertion | Frame_Shift_Ins | novel | c.9247_9248insTCATAGGCTT | p.Lys3083IlefsTer27 | p.K3083Ifs*27 | Q8WUY3 | protein_coding | TCGA-AN-A0FF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PRUNE2 | insertion | Nonsense_Mutation | novel | c.9245_9246insTAAAACACCGTAATCT | p.Leu3082PhefsTer5 | p.L3082Ffs*5 | Q8WUY3 | protein_coding | TCGA-AN-A0FF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PRUNE2 | insertion | Frame_Shift_Ins | novel | c.1709_1710insCCAGAACCTGCCCATAGAGA | p.Val571GlnfsTer22 | p.V571Qfs*22 | Q8WUY3 | protein_coding | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PRUNE2 | insertion | Frame_Shift_Ins | novel | c.1707_1708insCTTGCCG | p.Phe570LeufsTer13 | p.F570Lfs*13 | Q8WUY3 | protein_coding | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PRUNE2 | insertion | Nonsense_Mutation | novel | c.6674_6675insAAATAAATAAAATATATAAAAAATATTAAATTA | p.Ile2225_Pro2226insAsnLysTerAsnIleTerLysIleLeuAsnTyr | p.I2225_P2226insNK*NI*KILNY | Q8WUY3 | protein_coding | TCGA-AO-A0JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | leuprolide | SD | ||
PRUNE2 | insertion | Frame_Shift_Ins | novel | c.6882_6883insCCAATGAGGGTAGAGAGAAAACTAACTACATTTTC | p.Ser2295ProfsTer34 | p.S2295Pfs*34 | Q8WUY3 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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