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Gene: PPARD |
Gene summary for PPARD |
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Gene information | Species | Human | Gene symbol | PPARD | Gene ID | 5467 |
Gene name | peroxisome proliferator activated receptor delta | |
Gene Alias | FAAR | |
Cytomap | 6p21.31 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024RCW6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5467 | PPARD | CCI_1 | Human | Cervix | CC | 7.82e-09 | 9.89e-01 | 0.528 |
5467 | PPARD | CCI_2 | Human | Cervix | CC | 1.81e-05 | 6.11e-01 | 0.5249 |
5467 | PPARD | CCI_3 | Human | Cervix | CC | 4.06e-03 | 4.22e-01 | 0.516 |
5467 | PPARD | AEH-subject1 | Human | Endometrium | AEH | 7.84e-04 | 2.07e-01 | -0.3059 |
5467 | PPARD | AEH-subject5 | Human | Endometrium | AEH | 8.35e-12 | 3.13e-01 | -0.2953 |
5467 | PPARD | EEC-subject1 | Human | Endometrium | EEC | 3.53e-09 | 3.91e-01 | -0.2682 |
5467 | PPARD | EEC-subject4 | Human | Endometrium | EEC | 5.61e-04 | 2.38e-01 | -0.2571 |
5467 | PPARD | EEC-subject5 | Human | Endometrium | EEC | 8.05e-06 | 2.77e-01 | -0.249 |
5467 | PPARD | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 4.54e-03 | -1.40e-02 | -0.1869 |
5467 | PPARD | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 4.46e-02 | 2.38e-02 | -0.1875 |
5467 | PPARD | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.14e-04 | 5.00e-02 | -0.1917 |
5467 | PPARD | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.03e-02 | 1.25e-02 | -0.1916 |
5467 | PPARD | LZE4T | Human | Esophagus | ESCC | 2.56e-03 | 1.56e-01 | 0.0811 |
5467 | PPARD | LZE8T | Human | Esophagus | ESCC | 1.03e-03 | 8.61e-02 | 0.067 |
5467 | PPARD | LZE24T | Human | Esophagus | ESCC | 1.77e-09 | 1.72e-01 | 0.0596 |
5467 | PPARD | LZE21T | Human | Esophagus | ESCC | 1.43e-09 | 3.61e-01 | 0.0655 |
5467 | PPARD | LZE6T | Human | Esophagus | ESCC | 8.07e-07 | 2.04e-01 | 0.0845 |
5467 | PPARD | P1T-E | Human | Esophagus | ESCC | 4.86e-09 | 2.66e-01 | 0.0875 |
5467 | PPARD | P2T-E | Human | Esophagus | ESCC | 5.67e-10 | 2.29e-01 | 0.1177 |
5467 | PPARD | P4T-E | Human | Esophagus | ESCC | 9.97e-11 | 1.03e-01 | 0.1323 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004206010 | Cervix | CC | wound healing | 109/2311 | 422/18723 | 1.84e-14 | 1.57e-11 | 109 |
GO:00315898 | Cervix | CC | cell-substrate adhesion | 96/2311 | 363/18723 | 1.48e-13 | 8.85e-11 | 96 |
GO:009013210 | Cervix | CC | epithelium migration | 90/2311 | 360/18723 | 2.45e-11 | 6.11e-09 | 90 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:001063110 | Cervix | CC | epithelial cell migration | 89/2311 | 357/18723 | 3.72e-11 | 8.54e-09 | 89 |
GO:00085446 | Cervix | CC | epidermis development | 83/2311 | 324/18723 | 3.91e-11 | 8.54e-09 | 83 |
GO:009013010 | Cervix | CC | tissue migration | 90/2311 | 365/18723 | 5.42e-11 | 1.05e-08 | 90 |
GO:00506737 | Cervix | CC | epithelial cell proliferation | 98/2311 | 437/18723 | 2.01e-09 | 2.15e-07 | 98 |
GO:00512359 | Cervix | CC | maintenance of location | 78/2311 | 327/18723 | 5.18e-09 | 4.92e-07 | 78 |
GO:00060919 | Cervix | CC | generation of precursor metabolites and energy | 105/2311 | 490/18723 | 7.40e-09 | 6.61e-07 | 105 |
GO:005122210 | Cervix | CC | positive regulation of protein transport | 72/2311 | 303/18723 | 2.36e-08 | 1.70e-06 | 72 |
GO:190495110 | Cervix | CC | positive regulation of establishment of protein localization | 73/2311 | 319/18723 | 9.69e-08 | 5.25e-06 | 73 |
GO:00506787 | Cervix | CC | regulation of epithelial cell proliferation | 83/2311 | 381/18723 | 1.31e-07 | 6.42e-06 | 83 |
GO:00018908 | Cervix | CC | placenta development | 40/2311 | 144/18723 | 4.59e-07 | 1.77e-05 | 40 |
GO:00022379 | Cervix | CC | response to molecule of bacterial origin | 78/2311 | 363/18723 | 5.55e-07 | 2.06e-05 | 78 |
GO:004854510 | Cervix | CC | response to steroid hormone | 74/2311 | 339/18723 | 5.71e-07 | 2.09e-05 | 74 |
GO:00324969 | Cervix | CC | response to lipopolysaccharide | 74/2311 | 343/18723 | 9.15e-07 | 3.25e-05 | 74 |
GO:00614588 | Cervix | CC | reproductive system development | 87/2311 | 427/18723 | 1.37e-06 | 4.55e-05 | 87 |
GO:00305229 | Cervix | CC | intracellular receptor signaling pathway | 60/2311 | 265/18723 | 1.89e-06 | 5.97e-05 | 60 |
GO:00486088 | Cervix | CC | reproductive structure development | 86/2311 | 424/18723 | 1.90e-06 | 5.97e-05 | 86 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa043109 | Cervix | CC | Wnt signaling pathway | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa0431012 | Cervix | CC | Wnt signaling pathway | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa0431010 | Endometrium | AEH | Wnt signaling pathway | 37/1197 | 171/8465 | 4.68e-03 | 2.53e-02 | 1.86e-02 | 37 |
hsa0431013 | Endometrium | AEH | Wnt signaling pathway | 37/1197 | 171/8465 | 4.68e-03 | 2.53e-02 | 1.86e-02 | 37 |
hsa0431022 | Endometrium | EEC | Wnt signaling pathway | 40/1237 | 171/8465 | 1.37e-03 | 8.99e-03 | 6.70e-03 | 40 |
hsa0431032 | Endometrium | EEC | Wnt signaling pathway | 40/1237 | 171/8465 | 1.37e-03 | 8.99e-03 | 6.70e-03 | 40 |
hsa052215 | Esophagus | ESCC | Acute myeloid leukemia | 49/4205 | 67/8465 | 7.43e-05 | 3.07e-04 | 1.57e-04 | 49 |
hsa0522113 | Esophagus | ESCC | Acute myeloid leukemia | 49/4205 | 67/8465 | 7.43e-05 | 3.07e-04 | 1.57e-04 | 49 |
hsa033204 | Liver | HCC | PPAR signaling pathway | 48/4020 | 75/8465 | 2.83e-03 | 9.37e-03 | 5.21e-03 | 48 |
hsa05221 | Liver | HCC | Acute myeloid leukemia | 41/4020 | 67/8465 | 1.64e-02 | 3.90e-02 | 2.17e-02 | 41 |
hsa033205 | Liver | HCC | PPAR signaling pathway | 48/4020 | 75/8465 | 2.83e-03 | 9.37e-03 | 5.21e-03 | 48 |
hsa052211 | Liver | HCC | Acute myeloid leukemia | 41/4020 | 67/8465 | 1.64e-02 | 3.90e-02 | 2.17e-02 | 41 |
hsa043108 | Lung | IAC | Wnt signaling pathway | 40/1053 | 171/8465 | 4.56e-05 | 7.06e-04 | 4.69e-04 | 40 |
hsa0431011 | Lung | IAC | Wnt signaling pathway | 40/1053 | 171/8465 | 4.56e-05 | 7.06e-04 | 4.69e-04 | 40 |
hsa052214 | Oral cavity | OSCC | Acute myeloid leukemia | 42/3704 | 67/8465 | 1.34e-03 | 3.75e-03 | 1.91e-03 | 42 |
hsa0522112 | Oral cavity | OSCC | Acute myeloid leukemia | 42/3704 | 67/8465 | 1.34e-03 | 3.75e-03 | 1.91e-03 | 42 |
hsa0522121 | Oral cavity | EOLP | Acute myeloid leukemia | 19/1218 | 67/8465 | 2.20e-03 | 7.32e-03 | 4.32e-03 | 19 |
hsa0431016 | Oral cavity | EOLP | Wnt signaling pathway | 37/1218 | 171/8465 | 6.23e-03 | 1.83e-02 | 1.08e-02 | 37 |
hsa052213 | Oral cavity | EOLP | Acute myeloid leukemia | 19/1218 | 67/8465 | 2.20e-03 | 7.32e-03 | 4.32e-03 | 19 |
hsa0431017 | Oral cavity | EOLP | Wnt signaling pathway | 37/1218 | 171/8465 | 6.23e-03 | 1.83e-02 | 1.08e-02 | 37 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPARD | SNV | Missense_Mutation | c.237N>G | p.Asp79Glu | p.D79E | Q03181 | protein_coding | deleterious(0) | benign(0.401) | TCGA-55-7283-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PR | |
PPARD | SNV | Missense_Mutation | rs772540082 | c.1016A>G | p.Asn339Ser | p.N339S | Q03181 | protein_coding | deleterious(0) | possibly_damaging(0.585) | TCGA-69-A59K-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
PPARD | SNV | Missense_Mutation | rs200904269 | c.1256G>A | p.Arg419Gln | p.R419Q | Q03181 | protein_coding | tolerated(0.57) | benign(0.08) | TCGA-22-4604-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Targeted Molecular therapy | iressa | PD |
PPARD | SNV | Missense_Mutation | c.829N>C | p.Asp277His | p.D277H | Q03181 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-33-4583-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PPARD | SNV | Missense_Mutation | rs763849875 | c.214A>G | p.Met72Val | p.M72V | Q03181 | protein_coding | tolerated(0.73) | benign(0) | TCGA-58-A46K-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | PD |
PPARD | SNV | Missense_Mutation | novel | c.703N>A | p.Leu235Met | p.L235M | Q03181 | protein_coding | tolerated(0.25) | benign(0.262) | TCGA-CQ-A4CA-01 | Oral cavity | head & neck squamous cell carcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
PPARD | SNV | Missense_Mutation | novel | c.440N>T | p.Arg147Leu | p.R147L | Q03181 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-CR-7390-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PPARD | SNV | Missense_Mutation | novel | c.1112N>T | p.Glu371Val | p.E371V | Q03181 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-QK-A6VC-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPARD | SNV | Missense_Mutation | novel | c.390N>G | p.Phe130Leu | p.F130L | Q03181 | protein_coding | tolerated(0.26) | probably_damaging(0.996) | TCGA-QK-A8ZA-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
PPARD | SNV | Missense_Mutation | rs776822185 | c.386N>A | p.Arg129His | p.R129H | Q03181 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EJ-5521-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5467 | PPARD | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | PROPACHLOR | PROPACHLOR | ||
5467 | PPARD | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | DICHLOROPHEN | DICHLOROPHEN | ||
5467 | PPARD | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | BISPHENOL A | BISPHENOL A | ||
5467 | PPARD | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | TCMDC-123920 | CHEMBL1606 | ||
5467 | PPARD | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | GW7647 | GW7647 | 18162399 | |
5467 | PPARD | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | HYDRAMETHYLNON | HYDRAMETHYLNON | ||
5467 | PPARD | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | agonist | CHEMBL3544958 | CER-002 | |
5467 | PPARD | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | 12-HYDROXY-OCTADECANOIC ACID | CHEMBL292352 | ||
5467 | PPARD | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | L-165041 | CHEMBL153057 | ||
5467 | PPARD | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | CLOTRIMAZOLE | CLOTRIMAZOLE |
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