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Gene: POU6F2 |
Gene summary for POU6F2 |
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Gene information | Species | Human | Gene symbol | POU6F2 | Gene ID | 11281 |
Gene name | POU class 6 homeobox 2 | |
Gene Alias | RPF-1 | |
Cytomap | 7p14.1 | |
Gene Type | protein-coding | GO ID | GO:0001709 | UniProtAcc | P78424 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11281 | POU6F2 | LZE4T | Human | Esophagus | ESCC | 4.53e-04 | 1.83e-01 | 0.0811 |
11281 | POU6F2 | LZE20T | Human | Esophagus | ESCC | 3.16e-03 | 1.42e-01 | 0.0662 |
11281 | POU6F2 | LZE22T | Human | Esophagus | ESCC | 1.54e-04 | 3.08e-01 | 0.068 |
11281 | POU6F2 | LZE24T | Human | Esophagus | ESCC | 4.99e-09 | 2.05e-01 | 0.0596 |
11281 | POU6F2 | P1T-E | Human | Esophagus | ESCC | 1.05e-09 | 3.99e-01 | 0.0875 |
11281 | POU6F2 | P2T-E | Human | Esophagus | ESCC | 3.87e-34 | 5.27e-01 | 0.1177 |
11281 | POU6F2 | P4T-E | Human | Esophagus | ESCC | 4.59e-20 | 3.81e-01 | 0.1323 |
11281 | POU6F2 | P10T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.66e-01 | 0.116 |
11281 | POU6F2 | P11T-E | Human | Esophagus | ESCC | 2.46e-02 | 1.62e-01 | 0.1426 |
11281 | POU6F2 | P12T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.13e-01 | 0.1122 |
11281 | POU6F2 | P15T-E | Human | Esophagus | ESCC | 2.11e-03 | 1.05e-01 | 0.1149 |
11281 | POU6F2 | P16T-E | Human | Esophagus | ESCC | 1.61e-32 | 5.18e-01 | 0.1153 |
11281 | POU6F2 | P20T-E | Human | Esophagus | ESCC | 3.33e-28 | 5.76e-01 | 0.1124 |
11281 | POU6F2 | P22T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.82e-01 | 0.1236 |
11281 | POU6F2 | P24T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.26e-01 | 0.1287 |
11281 | POU6F2 | P26T-E | Human | Esophagus | ESCC | 2.20e-17 | 3.11e-01 | 0.1276 |
11281 | POU6F2 | P27T-E | Human | Esophagus | ESCC | 1.13e-16 | 3.53e-01 | 0.1055 |
11281 | POU6F2 | P28T-E | Human | Esophagus | ESCC | 7.90e-03 | 9.20e-02 | 0.1149 |
11281 | POU6F2 | P31T-E | Human | Esophagus | ESCC | 4.30e-10 | 1.50e-01 | 0.1251 |
11281 | POU6F2 | P32T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.85e-01 | 0.1666 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POU6F2 | SNV | Missense_Mutation | novel | c.1406N>A | p.Pro469His | p.P469H | P78424 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POU6F2 | SNV | Missense_Mutation | novel | c.2068N>C | p.Asn690His | p.N690H | P78424 | protein_coding | tolerated_low_confidence(0.08) | possibly_damaging(0.832) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
POU6F2 | SNV | Missense_Mutation | novel | c.1319N>A | p.Ser440Tyr | p.S440Y | P78424 | protein_coding | deleterious(0) | possibly_damaging(0.896) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
POU6F2 | SNV | Missense_Mutation | rs764143635 | c.1033N>A | p.Gly345Arg | p.G345R | P78424 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EY-A212-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
POU6F2 | SNV | Missense_Mutation | novel | c.1285C>T | p.Leu429Phe | p.L429F | P78424 | protein_coding | deleterious(0.04) | benign(0.03) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POU6F2 | SNV | Missense_Mutation | c.1801G>T | p.Gly601Trp | p.G601W | P78424 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CC-5258-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
POU6F2 | SNV | Missense_Mutation | rs535259814 | c.1084N>A | p.Gly362Ser | p.G362S | P78424 | protein_coding | tolerated(0.17) | benign(0.005) | TCGA-UB-A7MA-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Chemotherapy | gemcitabine | PD |
POU6F2 | SNV | Missense_Mutation | rs367834526 | c.817N>A | p.Pro273Thr | p.P273T | P78424 | protein_coding | deleterious_low_confidence(0.03) | benign(0.096) | TCGA-44-5644-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POU6F2 | SNV | Missense_Mutation | c.838N>A | p.Pro280Thr | p.P280T | P78424 | protein_coding | tolerated_low_confidence(0.09) | probably_damaging(0.994) | TCGA-44-7669-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | alimta | PD | |
POU6F2 | SNV | Missense_Mutation | c.1802N>T | p.Gly601Val | p.G601V | P78424 | protein_coding | deleterious(0) | benign(0.056) | TCGA-49-AARQ-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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