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Gene: POLM |
Gene summary for POLM |
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Gene information | Species | Human | Gene symbol | POLM | Gene ID | 27434 |
Gene name | DNA polymerase mu | |
Gene Alias | Pol Mu | |
Cytomap | 7p13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9NP87 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27434 | POLM | LZE4T | Human | Esophagus | ESCC | 3.00e-04 | 9.52e-02 | 0.0811 |
27434 | POLM | LZE5T | Human | Esophagus | ESCC | 2.91e-03 | 1.97e-01 | 0.0514 |
27434 | POLM | LZE8T | Human | Esophagus | ESCC | 7.58e-06 | 1.53e-01 | 0.067 |
27434 | POLM | LZE20T | Human | Esophagus | ESCC | 1.07e-02 | 1.05e-01 | 0.0662 |
27434 | POLM | LZE22D1 | Human | Esophagus | HGIN | 4.32e-04 | 1.94e-01 | 0.0595 |
27434 | POLM | LZE22T | Human | Esophagus | ESCC | 6.45e-04 | 2.55e-01 | 0.068 |
27434 | POLM | LZE24T | Human | Esophagus | ESCC | 7.46e-11 | 2.47e-01 | 0.0596 |
27434 | POLM | LZE6T | Human | Esophagus | ESCC | 4.52e-02 | 1.78e-01 | 0.0845 |
27434 | POLM | P1T-E | Human | Esophagus | ESCC | 2.06e-15 | 5.30e-01 | 0.0875 |
27434 | POLM | P2T-E | Human | Esophagus | ESCC | 3.41e-16 | 2.71e-01 | 0.1177 |
27434 | POLM | P4T-E | Human | Esophagus | ESCC | 8.12e-09 | 2.16e-01 | 0.1323 |
27434 | POLM | P5T-E | Human | Esophagus | ESCC | 7.17e-07 | 1.11e-01 | 0.1327 |
27434 | POLM | P8T-E | Human | Esophagus | ESCC | 1.40e-11 | 1.54e-01 | 0.0889 |
27434 | POLM | P9T-E | Human | Esophagus | ESCC | 9.24e-14 | 2.21e-01 | 0.1131 |
27434 | POLM | P10T-E | Human | Esophagus | ESCC | 1.71e-22 | 3.04e-01 | 0.116 |
27434 | POLM | P11T-E | Human | Esophagus | ESCC | 9.86e-10 | 2.69e-01 | 0.1426 |
27434 | POLM | P12T-E | Human | Esophagus | ESCC | 3.39e-16 | 2.71e-01 | 0.1122 |
27434 | POLM | P15T-E | Human | Esophagus | ESCC | 1.86e-16 | 3.31e-01 | 0.1149 |
27434 | POLM | P16T-E | Human | Esophagus | ESCC | 4.11e-22 | 3.80e-01 | 0.1153 |
27434 | POLM | P20T-E | Human | Esophagus | ESCC | 5.70e-16 | 4.12e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007189710 | Esophagus | HGIN | DNA biosynthetic process | 44/2587 | 180/18723 | 8.97e-05 | 1.96e-03 | 44 |
GO:007189716 | Esophagus | ESCC | DNA biosynthetic process | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
GO:00063024 | Esophagus | ESCC | double-strand break repair | 152/8552 | 251/18723 | 1.33e-06 | 1.62e-05 | 152 |
GO:00063101 | Esophagus | ESCC | DNA recombination | 168/8552 | 305/18723 | 5.58e-04 | 3.05e-03 | 168 |
GO:0006303 | Esophagus | ESCC | double-strand break repair via nonhomologous end joining | 43/8552 | 66/18723 | 1.10e-03 | 5.53e-03 | 43 |
GO:00718979 | Oral cavity | OSCC | DNA biosynthetic process | 106/7305 | 180/18723 | 4.86e-08 | 8.95e-07 | 106 |
GO:00063023 | Oral cavity | OSCC | double-strand break repair | 132/7305 | 251/18723 | 7.93e-06 | 8.52e-05 | 132 |
GO:0006310 | Oral cavity | OSCC | DNA recombination | 147/7305 | 305/18723 | 6.33e-04 | 3.56e-03 | 147 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POLM | SNV | Missense_Mutation | c.689N>T | p.Arg230Leu | p.R230L | Q9NP87 | protein_coding | tolerated(0.42) | benign(0) | TCGA-44-3918-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
POLM | SNV | Missense_Mutation | c.980G>T | p.Arg327Met | p.R327M | Q9NP87 | protein_coding | deleterious(0.01) | possibly_damaging(0.893) | TCGA-50-5941-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unspecific | Cisplatin | Complete Response | |
POLM | SNV | Missense_Mutation | novel | c.542G>T | p.Arg181Ile | p.R181I | Q9NP87 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-55-A4DG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
POLM | SNV | Missense_Mutation | c.1153N>A | p.Glu385Lys | p.E385K | Q9NP87 | protein_coding | tolerated(0.24) | benign(0.046) | TCGA-75-5125-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | PD | |
POLM | SNV | Missense_Mutation | rs754904576 | c.560N>G | p.Lys187Arg | p.K187R | Q9NP87 | protein_coding | tolerated(0.1) | benign(0.038) | TCGA-75-6211-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | PD |
POLM | SNV | Missense_Mutation | novel | c.203N>T | p.His68Leu | p.H68L | Q9NP87 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-85-8351-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
POLM | SNV | Missense_Mutation | novel | c.277N>T | p.Gly93Cys | p.G93C | Q9NP87 | protein_coding | deleterious(0.01) | benign(0.007) | TCGA-O2-A5IB-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
POLM | SNV | Missense_Mutation | novel | c.500N>T | p.Ala167Val | p.A167V | Q9NP87 | protein_coding | tolerated(0.19) | probably_damaging(0.999) | TCGA-CN-6021-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
POLM | SNV | Missense_Mutation | novel | c.637N>A | p.Val213Ile | p.V213I | Q9NP87 | protein_coding | tolerated(1) | benign(0.069) | TCGA-CQ-A4C7-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
POLM | insertion | Frame_Shift_Ins | rs745933237 | c.290_291insC | p.Ala98SerfsTer73 | p.A98Sfs*73 | Q9NP87 | protein_coding | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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