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Gene: PNPT1 |
Gene summary for PNPT1 |
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Gene information | Species | Human | Gene symbol | PNPT1 | Gene ID | 87178 |
Gene name | polyribonucleotide nucleotidyltransferase 1 | |
Gene Alias | COXPD13 | |
Cytomap | 2p16.1 | |
Gene Type | protein-coding | GO ID | GO:0000957 | UniProtAcc | Q8TCS8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
87178 | PNPT1 | LZE2T | Human | Esophagus | ESCC | 1.87e-03 | 4.84e-01 | 0.082 |
87178 | PNPT1 | LZE4T | Human | Esophagus | ESCC | 2.90e-05 | 2.30e-01 | 0.0811 |
87178 | PNPT1 | LZE7T | Human | Esophagus | ESCC | 5.70e-06 | 5.14e-01 | 0.0667 |
87178 | PNPT1 | LZE8T | Human | Esophagus | ESCC | 1.15e-04 | 1.23e-01 | 0.067 |
87178 | PNPT1 | LZE22T | Human | Esophagus | ESCC | 3.27e-02 | 3.88e-01 | 0.068 |
87178 | PNPT1 | LZE24T | Human | Esophagus | ESCC | 6.83e-18 | 4.34e-01 | 0.0596 |
87178 | PNPT1 | LZE21T | Human | Esophagus | ESCC | 3.13e-04 | 2.66e-01 | 0.0655 |
87178 | PNPT1 | P1T-E | Human | Esophagus | ESCC | 1.94e-09 | 4.78e-01 | 0.0875 |
87178 | PNPT1 | P2T-E | Human | Esophagus | ESCC | 3.45e-43 | 8.73e-01 | 0.1177 |
87178 | PNPT1 | P4T-E | Human | Esophagus | ESCC | 3.59e-21 | 5.12e-01 | 0.1323 |
87178 | PNPT1 | P5T-E | Human | Esophagus | ESCC | 3.99e-15 | 3.81e-01 | 0.1327 |
87178 | PNPT1 | P8T-E | Human | Esophagus | ESCC | 1.63e-12 | 2.35e-01 | 0.0889 |
87178 | PNPT1 | P9T-E | Human | Esophagus | ESCC | 6.25e-11 | 3.35e-01 | 0.1131 |
87178 | PNPT1 | P10T-E | Human | Esophagus | ESCC | 1.77e-24 | 3.94e-01 | 0.116 |
87178 | PNPT1 | P11T-E | Human | Esophagus | ESCC | 1.35e-11 | 6.28e-01 | 0.1426 |
87178 | PNPT1 | P12T-E | Human | Esophagus | ESCC | 1.01e-27 | 5.62e-01 | 0.1122 |
87178 | PNPT1 | P15T-E | Human | Esophagus | ESCC | 1.55e-26 | 5.84e-01 | 0.1149 |
87178 | PNPT1 | P16T-E | Human | Esophagus | ESCC | 2.22e-33 | 5.51e-01 | 0.1153 |
87178 | PNPT1 | P17T-E | Human | Esophagus | ESCC | 2.17e-05 | 3.65e-01 | 0.1278 |
87178 | PNPT1 | P19T-E | Human | Esophagus | ESCC | 1.74e-04 | 4.94e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0006403110 | Esophagus | ESCC | RNA localization | 166/8552 | 201/18723 | 1.95e-27 | 6.18e-25 | 166 |
GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:0031331111 | Esophagus | ESCC | positive regulation of cellular catabolic process | 292/8552 | 427/18723 | 8.67e-22 | 1.53e-19 | 292 |
GO:1903311110 | Esophagus | ESCC | regulation of mRNA metabolic process | 210/8552 | 288/18723 | 3.25e-21 | 5.56e-19 | 210 |
GO:0006401110 | Esophagus | ESCC | RNA catabolic process | 204/8552 | 278/18723 | 3.39e-21 | 5.66e-19 | 204 |
GO:005123617 | Esophagus | ESCC | establishment of RNA localization | 134/8552 | 166/18723 | 1.23e-20 | 1.81e-18 | 134 |
GO:0045333110 | Esophagus | ESCC | cellular respiration | 173/8552 | 230/18723 | 4.53e-20 | 5.99e-18 | 173 |
GO:005065717 | Esophagus | ESCC | nucleic acid transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:005065817 | Esophagus | ESCC | RNA transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:0006839110 | Esophagus | ESCC | mitochondrial transport | 187/8552 | 254/18723 | 8.35e-20 | 9.81e-18 | 187 |
GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
GO:0034655110 | Esophagus | ESCC | nucleobase-containing compound catabolic process | 272/8552 | 407/18723 | 2.92e-18 | 2.90e-16 | 272 |
GO:0006402110 | Esophagus | ESCC | mRNA catabolic process | 170/8552 | 232/18723 | 8.70e-18 | 8.00e-16 | 170 |
GO:0015980110 | Esophagus | ESCC | energy derivation by oxidation of organic compounds | 220/8552 | 318/18723 | 1.20e-17 | 1.09e-15 | 220 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:001593117 | Esophagus | ESCC | nucleobase-containing compound transport | 162/8552 | 222/18723 | 9.87e-17 | 7.93e-15 | 162 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301824 | Esophagus | ESCC | RNA degradation | 62/4205 | 79/8465 | 1.18e-07 | 9.39e-07 | 4.81e-07 | 62 |
hsa0301834 | Esophagus | ESCC | RNA degradation | 62/4205 | 79/8465 | 1.18e-07 | 9.39e-07 | 4.81e-07 | 62 |
hsa030182 | Liver | HCC | RNA degradation | 58/4020 | 79/8465 | 2.29e-06 | 2.19e-05 | 1.22e-05 | 58 |
hsa030183 | Liver | HCC | RNA degradation | 58/4020 | 79/8465 | 2.29e-06 | 2.19e-05 | 1.22e-05 | 58 |
hsa030189 | Oral cavity | OSCC | RNA degradation | 59/3704 | 79/8465 | 2.05e-08 | 1.91e-07 | 9.70e-08 | 59 |
hsa0301814 | Oral cavity | OSCC | RNA degradation | 59/3704 | 79/8465 | 2.05e-08 | 1.91e-07 | 9.70e-08 | 59 |
hsa0301823 | Oral cavity | LP | RNA degradation | 39/2418 | 79/8465 | 6.98e-05 | 4.38e-04 | 2.83e-04 | 39 |
hsa0301833 | Oral cavity | LP | RNA degradation | 39/2418 | 79/8465 | 6.98e-05 | 4.38e-04 | 2.83e-04 | 39 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PNPT1 | SNV | Missense_Mutation | c.1343N>G | p.Leu448Arg | p.L448R | Q8TCS8 | protein_coding | deleterious(0.02) | probably_damaging(0.989) | TCGA-D1-A16Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PNPT1 | SNV | Missense_Mutation | novel | c.265N>G | p.Lys89Glu | p.K89E | Q8TCS8 | protein_coding | tolerated(0.08) | benign(0.11) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
PNPT1 | SNV | Missense_Mutation | c.1555C>A | p.Pro519Thr | p.P519T | Q8TCS8 | protein_coding | tolerated(0.14) | benign(0.158) | TCGA-D1-A176-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PNPT1 | SNV | Missense_Mutation | novel | c.1421C>T | p.Ser474Phe | p.S474F | Q8TCS8 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PNPT1 | SNV | Missense_Mutation | rs766238633 | c.1754N>C | p.Ile585Thr | p.I585T | Q8TCS8 | protein_coding | deleterious(0.03) | benign(0.098) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PNPT1 | SNV | Missense_Mutation | c.1859T>G | p.Phe620Cys | p.F620C | Q8TCS8 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PNPT1 | insertion | Frame_Shift_Ins | novel | c.1265dupA | p.Asn422LysfsTer14 | p.N422Kfs*14 | Q8TCS8 | protein_coding | TCGA-AX-A2HA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PNPT1 | deletion | In_Frame_Del | novel | c.1832_1837delNNNNNN | p.Gln611_Val612del | p.Q611_V612del | Q8TCS8 | protein_coding | TCGA-G3-AAV6-01 | Liver | liver hepatocellular carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
PNPT1 | SNV | Missense_Mutation | c.1175N>T | p.Gln392Leu | p.Q392L | Q8TCS8 | protein_coding | deleterious(0) | probably_damaging(0.914) | TCGA-50-6593-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
PNPT1 | SNV | Missense_Mutation | c.322N>T | p.Ala108Ser | p.A108S | Q8TCS8 | protein_coding | deleterious(0.03) | probably_damaging(0.951) | TCGA-69-7765-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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