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Gene: PMPCA |
Gene summary for PMPCA |
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Gene information | Species | Human | Gene symbol | PMPCA | Gene ID | 23203 |
Gene name | peptidase, mitochondrial processing subunit alpha | |
Gene Alias | Alpha-MPP | |
Cytomap | 9q34.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q10713 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23203 | PMPCA | LZE4T | Human | Esophagus | ESCC | 7.69e-09 | 2.02e-01 | 0.0811 |
23203 | PMPCA | LZE7T | Human | Esophagus | ESCC | 2.00e-06 | 5.93e-01 | 0.0667 |
23203 | PMPCA | LZE8T | Human | Esophagus | ESCC | 5.51e-07 | 2.83e-01 | 0.067 |
23203 | PMPCA | LZE20T | Human | Esophagus | ESCC | 1.50e-05 | 2.49e-01 | 0.0662 |
23203 | PMPCA | LZE22D1 | Human | Esophagus | HGIN | 9.54e-04 | 1.28e-02 | 0.0595 |
23203 | PMPCA | LZE24T | Human | Esophagus | ESCC | 8.24e-08 | 1.79e-01 | 0.0596 |
23203 | PMPCA | LZE6T | Human | Esophagus | ESCC | 4.78e-07 | 1.57e-01 | 0.0845 |
23203 | PMPCA | P1T-E | Human | Esophagus | ESCC | 9.20e-05 | 2.94e-01 | 0.0875 |
23203 | PMPCA | P2T-E | Human | Esophagus | ESCC | 3.07e-28 | 5.61e-01 | 0.1177 |
23203 | PMPCA | P4T-E | Human | Esophagus | ESCC | 2.58e-16 | 2.90e-01 | 0.1323 |
23203 | PMPCA | P5T-E | Human | Esophagus | ESCC | 7.58e-09 | 2.07e-01 | 0.1327 |
23203 | PMPCA | P8T-E | Human | Esophagus | ESCC | 2.11e-18 | 3.63e-01 | 0.0889 |
23203 | PMPCA | P9T-E | Human | Esophagus | ESCC | 3.63e-12 | 2.21e-01 | 0.1131 |
23203 | PMPCA | P10T-E | Human | Esophagus | ESCC | 2.56e-24 | 4.87e-01 | 0.116 |
23203 | PMPCA | P11T-E | Human | Esophagus | ESCC | 1.40e-11 | 5.15e-01 | 0.1426 |
23203 | PMPCA | P12T-E | Human | Esophagus | ESCC | 1.22e-21 | 3.46e-01 | 0.1122 |
23203 | PMPCA | P15T-E | Human | Esophagus | ESCC | 3.27e-21 | 3.03e-01 | 0.1149 |
23203 | PMPCA | P16T-E | Human | Esophagus | ESCC | 5.14e-16 | 3.14e-01 | 0.1153 |
23203 | PMPCA | P17T-E | Human | Esophagus | ESCC | 7.62e-08 | 4.28e-01 | 0.1278 |
23203 | PMPCA | P20T-E | Human | Esophagus | ESCC | 6.26e-12 | 1.83e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007259420 | Esophagus | HGIN | establishment of protein localization to organelle | 120/2587 | 422/18723 | 1.73e-15 | 4.00e-13 | 120 |
GO:000683920 | Esophagus | HGIN | mitochondrial transport | 74/2587 | 254/18723 | 1.32e-10 | 1.32e-08 | 74 |
GO:007058520 | Esophagus | HGIN | protein localization to mitochondrion | 43/2587 | 125/18723 | 4.43e-09 | 3.03e-07 | 43 |
GO:007265520 | Esophagus | HGIN | establishment of protein localization to mitochondrion | 41/2587 | 120/18723 | 1.26e-08 | 7.96e-07 | 41 |
GO:000660525 | Esophagus | HGIN | protein targeting | 78/2587 | 314/18723 | 1.08e-07 | 5.47e-06 | 78 |
GO:000662620 | Esophagus | HGIN | protein targeting to mitochondrion | 33/2587 | 100/18723 | 7.99e-07 | 3.35e-05 | 33 |
GO:005160417 | Esophagus | HGIN | protein maturation | 68/2587 | 294/18723 | 9.77e-06 | 2.86e-04 | 68 |
GO:00164857 | Esophagus | HGIN | protein processing | 49/2587 | 225/18723 | 7.04e-04 | 9.52e-03 | 49 |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
GO:0006839110 | Esophagus | ESCC | mitochondrial transport | 187/8552 | 254/18723 | 8.35e-20 | 9.81e-18 | 187 |
GO:0072655110 | Esophagus | ESCC | establishment of protein localization to mitochondrion | 97/8552 | 120/18723 | 2.17e-15 | 1.33e-13 | 97 |
GO:0070585110 | Esophagus | ESCC | protein localization to mitochondrion | 100/8552 | 125/18723 | 2.96e-15 | 1.77e-13 | 100 |
GO:0006626110 | Esophagus | ESCC | protein targeting to mitochondrion | 81/8552 | 100/18723 | 3.60e-13 | 1.67e-11 | 81 |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:001648514 | Esophagus | ESCC | protein processing | 134/8552 | 225/18723 | 1.81e-05 | 1.60e-04 | 134 |
GO:007259422 | Liver | HCC | establishment of protein localization to organelle | 299/7958 | 422/18723 | 1.06e-32 | 6.10e-30 | 299 |
GO:000660512 | Liver | HCC | protein targeting | 219/7958 | 314/18723 | 7.74e-23 | 1.49e-20 | 219 |
GO:000683912 | Liver | HCC | mitochondrial transport | 184/7958 | 254/18723 | 2.30e-22 | 3.83e-20 | 184 |
GO:007265512 | Liver | HCC | establishment of protein localization to mitochondrion | 98/7958 | 120/18723 | 1.18e-18 | 1.46e-16 | 98 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PMPCA | SNV | Missense_Mutation | novel | c.1521G>C | p.Gln507His | p.Q507H | Q10713 | protein_coding | deleterious(0.03) | benign(0.087) | TCGA-CQ-7071-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PMPCA | SNV | Missense_Mutation | novel | c.1312N>T | p.Asn438Tyr | p.N438Y | Q10713 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CR-7395-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PMPCA | SNV | Missense_Mutation | c.466G>C | p.Asp156His | p.D156H | Q10713 | protein_coding | tolerated(0.31) | benign(0.082) | TCGA-CV-6961-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
PMPCA | SNV | Missense_Mutation | novel | c.1419G>T | p.Lys473Asn | p.K473N | Q10713 | protein_coding | tolerated(0.06) | benign(0.097) | TCGA-CV-A45W-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PMPCA | SNV | Missense_Mutation | rs751214293 | c.1255N>A | p.Val419Met | p.V419M | Q10713 | protein_coding | deleterious(0.02) | possibly_damaging(0.833) | TCGA-YL-A8SJ-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | PD |
PMPCA | SNV | Missense_Mutation | c.595N>T | p.Pro199Ser | p.P199S | Q10713 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PMPCA | SNV | Missense_Mutation | c.199N>G | p.Thr67Ala | p.T67A | Q10713 | protein_coding | tolerated(0.07) | possibly_damaging(0.468) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PMPCA | SNV | Missense_Mutation | rs368032224 | c.1525G>A | p.Ala509Thr | p.A509T | Q10713 | protein_coding | deleterious(0.04) | probably_damaging(0.966) | TCGA-BR-8368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PMPCA | SNV | Missense_Mutation | c.1121T>C | p.Met374Thr | p.M374T | Q10713 | protein_coding | deleterious(0) | possibly_damaging(0.809) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
PMPCA | SNV | Missense_Mutation | c.595N>T | p.Pro199Ser | p.P199S | Q10713 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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