![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PLEKHH2 |
Gene summary for PLEKHH2 |
![]() |
Gene information | Species | Human | Gene symbol | PLEKHH2 | Gene ID | 130271 |
Gene name | pleckstrin homology, MyTH4 and FERM domain containing H2 | |
Gene Alias | PLEKHH1L | |
Cytomap | 2p21 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q8IVE3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
130271 | PLEKHH2 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.78e-09 | 4.21e-01 | -0.0166 |
130271 | PLEKHH2 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.20e-15 | 5.15e-01 | -0.0132 |
130271 | PLEKHH2 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 4.57e-15 | 5.27e-01 | -0.013 |
130271 | PLEKHH2 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.51e-09 | 4.48e-01 | -0.0121 |
130271 | PLEKHH2 | PTC01 | Human | Thyroid | PTC | 6.12e-03 | 2.66e-02 | 0.1899 |
130271 | PLEKHH2 | PTC05 | Human | Thyroid | PTC | 6.49e-10 | 2.35e-01 | 0.2065 |
130271 | PLEKHH2 | PTC06 | Human | Thyroid | PTC | 4.30e-08 | 9.00e-02 | 0.2057 |
130271 | PLEKHH2 | PTC07 | Human | Thyroid | PTC | 2.08e-03 | 9.34e-02 | 0.2044 |
130271 | PLEKHH2 | ATC09 | Human | Thyroid | ATC | 3.91e-04 | 1.34e-01 | 0.2871 |
130271 | PLEKHH2 | ATC12 | Human | Thyroid | ATC | 5.53e-03 | 1.45e-01 | 0.34 |
130271 | PLEKHH2 | ATC13 | Human | Thyroid | ATC | 2.13e-42 | 7.74e-01 | 0.34 |
130271 | PLEKHH2 | ATC1 | Human | Thyroid | ATC | 8.70e-04 | 1.47e-01 | 0.2878 |
130271 | PLEKHH2 | ATC4 | Human | Thyroid | ATC | 1.51e-06 | 1.90e-01 | 0.34 |
130271 | PLEKHH2 | ATC5 | Human | Thyroid | ATC | 1.78e-46 | 8.16e-01 | 0.34 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00070158 | Lung | IAC | actin filament organization | 92/2061 | 442/18723 | 1.01e-09 | 1.93e-07 | 92 |
GO:00329708 | Lung | IAC | regulation of actin filament-based process | 77/2061 | 397/18723 | 4.85e-07 | 3.10e-05 | 77 |
GO:00329568 | Lung | IAC | regulation of actin cytoskeleton organization | 70/2061 | 358/18723 | 1.17e-06 | 6.20e-05 | 70 |
GO:00106398 | Lung | IAC | negative regulation of organelle organization | 68/2061 | 348/18723 | 1.69e-06 | 8.24e-05 | 68 |
GO:19029038 | Lung | IAC | regulation of supramolecular fiber organization | 73/2061 | 383/18723 | 1.87e-06 | 8.87e-05 | 73 |
GO:00514947 | Lung | IAC | negative regulation of cytoskeleton organization | 38/2061 | 163/18723 | 5.35e-06 | 2.08e-04 | 38 |
GO:01100538 | Lung | IAC | regulation of actin filament organization | 54/2061 | 278/18723 | 2.27e-05 | 6.28e-04 | 54 |
GO:19029047 | Lung | IAC | negative regulation of supramolecular fiber organization | 37/2061 | 167/18723 | 2.38e-05 | 6.50e-04 | 37 |
GO:00325357 | Lung | IAC | regulation of cellular component size | 65/2061 | 383/18723 | 2.56e-04 | 4.26e-03 | 65 |
GO:00432422 | Lung | IAC | negative regulation of protein-containing complex disassembly | 19/2061 | 82/18723 | 1.23e-03 | 1.42e-02 | 19 |
GO:00224118 | Lung | IAC | cellular component disassembly | 68/2061 | 443/18723 | 2.89e-03 | 2.60e-02 | 68 |
GO:00081548 | Lung | IAC | actin polymerization or depolymerization | 37/2061 | 218/18723 | 4.96e-03 | 3.79e-02 | 37 |
GO:0022411113 | Thyroid | PTC | cellular component disassembly | 232/5968 | 443/18723 | 1.36e-19 | 1.75e-17 | 232 |
GO:1902903113 | Thyroid | PTC | regulation of supramolecular fiber organization | 202/5968 | 383/18723 | 1.16e-17 | 1.15e-15 | 202 |
GO:0007015112 | Thyroid | PTC | actin filament organization | 225/5968 | 442/18723 | 3.76e-17 | 3.44e-15 | 225 |
GO:0032956113 | Thyroid | PTC | regulation of actin cytoskeleton organization | 182/5968 | 358/18723 | 4.64e-14 | 2.79e-12 | 182 |
GO:0032970113 | Thyroid | PTC | regulation of actin filament-based process | 197/5968 | 397/18723 | 8.91e-14 | 4.89e-12 | 197 |
GO:0110053112 | Thyroid | PTC | regulation of actin filament organization | 146/5968 | 278/18723 | 5.87e-13 | 2.85e-11 | 146 |
GO:000815426 | Thyroid | PTC | actin polymerization or depolymerization | 117/5968 | 218/18723 | 1.85e-11 | 7.21e-10 | 117 |
GO:0032535112 | Thyroid | PTC | regulation of cellular component size | 181/5968 | 383/18723 | 1.70e-10 | 5.64e-09 | 181 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLEKHH2 | SNV | Missense_Mutation | c.3002N>A | p.Ser1001Tyr | p.S1001Y | Q8IVE3 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PLEKHH2 | SNV | Missense_Mutation | novel | c.3814N>A | p.Glu1272Lys | p.E1272K | Q8IVE3 | protein_coding | tolerated(0.08) | possibly_damaging(0.781) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PLEKHH2 | deletion | Frame_Shift_Del | c.3234delN | p.Lys1079AsnfsTer10 | p.K1079Nfs*10 | Q8IVE3 | protein_coding | TCGA-AA-A02K-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PD | |||
PLEKHH2 | insertion | Frame_Shift_Ins | novel | c.3711_3712insACTTCTGTTTC | p.Tyr1238ThrfsTer12 | p.Y1238Tfs*12 | Q8IVE3 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PLEKHH2 | insertion | Frame_Shift_Ins | novel | c.1332_1333insA | p.Asn445LysfsTer22 | p.N445Kfs*22 | Q8IVE3 | protein_coding | TCGA-DM-A280-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PLEKHH2 | SNV | Missense_Mutation | novel | c.3998N>T | p.Ala1333Val | p.A1333V | Q8IVE3 | protein_coding | tolerated(0.61) | benign(0.007) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLEKHH2 | SNV | Missense_Mutation | novel | c.797N>T | p.Arg266Ile | p.R266I | Q8IVE3 | protein_coding | tolerated(0.06) | benign(0.007) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PLEKHH2 | SNV | Missense_Mutation | novel | c.2360N>G | p.Glu787Gly | p.E787G | Q8IVE3 | protein_coding | deleterious(0) | possibly_damaging(0.9) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PLEKHH2 | SNV | Missense_Mutation | rs183733596 | c.3089N>A | p.Arg1030Gln | p.R1030Q | Q8IVE3 | protein_coding | tolerated(0.3) | benign(0.053) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PLEKHH2 | SNV | Missense_Mutation | rs372835795 | c.4010N>A | p.Arg1337His | p.R1337H | Q8IVE3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
130271 | PLEKHH2 | NA | atenolol | ATENOLOL | 27670767 | |
130271 | PLEKHH2 | NA | verapamil | VERAPAMIL | 27670767 |
Page: 1 |