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Gene: PLEKHG6 |
Gene summary for PLEKHG6 |
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Gene information | Species | Human | Gene symbol | PLEKHG6 | Gene ID | 55200 |
Gene name | pleckstrin homology and RhoGEF domain containing G6 | |
Gene Alias | MyoGEF | |
Cytomap | 12p13.31 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q3KR16 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55200 | PLEKHG6 | LZE20T | Human | Esophagus | ESCC | 3.05e-02 | 1.24e-01 | 0.0662 |
55200 | PLEKHG6 | LZE24T | Human | Esophagus | ESCC | 3.55e-02 | 9.19e-02 | 0.0596 |
55200 | PLEKHG6 | P1T-E | Human | Esophagus | ESCC | 2.36e-08 | 4.02e-01 | 0.0875 |
55200 | PLEKHG6 | P2T-E | Human | Esophagus | ESCC | 7.07e-38 | 6.75e-01 | 0.1177 |
55200 | PLEKHG6 | P4T-E | Human | Esophagus | ESCC | 3.25e-12 | 3.05e-01 | 0.1323 |
55200 | PLEKHG6 | P5T-E | Human | Esophagus | ESCC | 7.07e-12 | 2.44e-01 | 0.1327 |
55200 | PLEKHG6 | P8T-E | Human | Esophagus | ESCC | 2.40e-09 | 2.07e-01 | 0.0889 |
55200 | PLEKHG6 | P9T-E | Human | Esophagus | ESCC | 2.61e-04 | 1.20e-01 | 0.1131 |
55200 | PLEKHG6 | P11T-E | Human | Esophagus | ESCC | 4.90e-02 | 1.64e-01 | 0.1426 |
55200 | PLEKHG6 | P12T-E | Human | Esophagus | ESCC | 3.57e-17 | 3.34e-01 | 0.1122 |
55200 | PLEKHG6 | P15T-E | Human | Esophagus | ESCC | 9.41e-07 | 2.07e-01 | 0.1149 |
55200 | PLEKHG6 | P16T-E | Human | Esophagus | ESCC | 1.08e-08 | 8.97e-02 | 0.1153 |
55200 | PLEKHG6 | P22T-E | Human | Esophagus | ESCC | 1.46e-03 | 9.88e-02 | 0.1236 |
55200 | PLEKHG6 | P23T-E | Human | Esophagus | ESCC | 1.70e-09 | 2.61e-01 | 0.108 |
55200 | PLEKHG6 | P24T-E | Human | Esophagus | ESCC | 4.01e-03 | 1.59e-01 | 0.1287 |
55200 | PLEKHG6 | P26T-E | Human | Esophagus | ESCC | 8.59e-05 | 1.45e-01 | 0.1276 |
55200 | PLEKHG6 | P27T-E | Human | Esophagus | ESCC | 8.51e-11 | 2.44e-01 | 0.1055 |
55200 | PLEKHG6 | P28T-E | Human | Esophagus | ESCC | 5.38e-15 | 2.98e-01 | 0.1149 |
55200 | PLEKHG6 | P30T-E | Human | Esophagus | ESCC | 3.29e-06 | 2.65e-01 | 0.137 |
55200 | PLEKHG6 | P31T-E | Human | Esophagus | ESCC | 9.85e-10 | 1.46e-01 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005105610 | Esophagus | ESCC | regulation of small GTPase mediated signal transduction | 157/8552 | 302/18723 | 1.55e-02 | 4.98e-02 | 157 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLEKHG6 | SNV | Missense_Mutation | c.254N>A | p.Gly85Asp | p.G85D | Q3KR16 | protein_coding | tolerated(0.1) | benign(0) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PLEKHG6 | SNV | Missense_Mutation | rs776513105 | c.1660G>A | p.Ala554Thr | p.A554T | Q3KR16 | protein_coding | tolerated(0.7) | benign(0.003) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLEKHG6 | SNV | Missense_Mutation | rs141375062 | c.2192G>A | p.Arg731His | p.R731H | Q3KR16 | protein_coding | tolerated_low_confidence(0.72) | benign(0) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLEKHG6 | SNV | Missense_Mutation | novel | c.131N>T | p.Pro44Leu | p.P44L | Q3KR16 | protein_coding | tolerated_low_confidence(0.49) | benign(0) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLEKHG6 | SNV | Missense_Mutation | novel | c.533N>T | p.Arg178Ile | p.R178I | Q3KR16 | protein_coding | deleterious(0.03) | possibly_damaging(0.642) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PLEKHG6 | SNV | Missense_Mutation | novel | c.322G>A | p.Val108Met | p.V108M | Q3KR16 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLEKHG6 | SNV | Missense_Mutation | rs746629523 | c.196N>A | p.Ala66Thr | p.A66T | Q3KR16 | protein_coding | tolerated(0.32) | benign(0) | TCGA-EY-A5W2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLEKHG6 | SNV | Missense_Mutation | novel | c.934N>T | p.Arg312Cys | p.R312C | Q3KR16 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-QS-A5YR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PLEKHG6 | deletion | Frame_Shift_Del | novel | c.2051_2054delNNNN | p.Leu685ThrfsTer38 | p.L685Tfs*38 | Q3KR16 | protein_coding | TCGA-B5-A11L-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
PLEKHG6 | SNV | Missense_Mutation | novel | c.2225N>C | p.Ile742Thr | p.I742T | Q3KR16 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.987) | TCGA-DD-A1EE-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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