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Gene: PLCH2 |
Gene summary for PLCH2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | PLCH2 | Gene ID | 9651 |
Gene name | phospholipase C eta 2 | |
Gene Alias | PLC-L4 | |
Cytomap | 1p36.32 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | O75038 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9651 | PLCH2 | C04 | Human | Oral cavity | OSCC | 1.67e-07 | 3.36e-01 | 0.2633 |
9651 | PLCH2 | C21 | Human | Oral cavity | OSCC | 4.86e-12 | 3.46e-01 | 0.2678 |
9651 | PLCH2 | C30 | Human | Oral cavity | OSCC | 1.12e-28 | 1.04e+00 | 0.3055 |
9651 | PLCH2 | C38 | Human | Oral cavity | OSCC | 8.63e-05 | 4.45e-01 | 0.172 |
9651 | PLCH2 | C43 | Human | Oral cavity | OSCC | 7.46e-20 | 4.21e-01 | 0.1704 |
9651 | PLCH2 | C46 | Human | Oral cavity | OSCC | 1.48e-09 | 2.37e-01 | 0.1673 |
9651 | PLCH2 | C51 | Human | Oral cavity | OSCC | 1.61e-03 | 2.71e-01 | 0.2674 |
9651 | PLCH2 | C09 | Human | Oral cavity | OSCC | 2.91e-12 | 3.40e-01 | 0.1431 |
9651 | PLCH2 | LN22 | Human | Oral cavity | OSCC | 3.01e-02 | 3.03e-01 | 0.1733 |
9651 | PLCH2 | LN46 | Human | Oral cavity | OSCC | 2.64e-05 | 2.57e-01 | 0.1666 |
9651 | PLCH2 | LP15 | Human | Oral cavity | LP | 1.44e-03 | 6.76e-01 | 0.2174 |
9651 | PLCH2 | SYSMH2 | Human | Oral cavity | OSCC | 7.25e-05 | 1.53e-01 | 0.2326 |
9651 | PLCH2 | SYSMH3 | Human | Oral cavity | OSCC | 2.19e-27 | 5.45e-01 | 0.2442 |
9651 | PLCH2 | SYSMH4 | Human | Oral cavity | OSCC | 3.27e-02 | 1.32e-01 | 0.1226 |
9651 | PLCH2 | SYSMH5 | Human | Oral cavity | OSCC | 1.56e-05 | 1.81e-01 | 0.0647 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | EOLP: Erosive Oral lichen planus | |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00066445 | Oral cavity | OSCC | phospholipid metabolic process | 175/7305 | 383/18723 | 4.21e-03 | 1.71e-02 | 175 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLCH2 | SNV | Missense_Mutation | rs370344110 | c.553G>A | p.Gly185Arg | p.G185R | O75038 | protein_coding | deleterious(0.02) | probably_damaging(0.954) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLCH2 | SNV | Missense_Mutation | novel | c.1213A>G | p.Lys405Glu | p.K405E | O75038 | protein_coding | deleterious(0.05) | possibly_damaging(0.842) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLCH2 | SNV | Missense_Mutation | novel | c.3746N>A | p.Pro1249His | p.P1249H | O75038 | protein_coding | deleterious_low_confidence(0) | benign(0.204) | TCGA-BG-A220-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLCH2 | SNV | Missense_Mutation | rs780172563 | c.2501N>A | p.Arg834His | p.R834H | O75038 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D1-A16F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLCH2 | SNV | Missense_Mutation | novel | c.1696N>C | p.Ala566Pro | p.A566P | O75038 | protein_coding | tolerated(0.15) | benign(0.007) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
PLCH2 | SNV | Missense_Mutation | rs760790950 | c.544G>A | p.Asp182Asn | p.D182N | O75038 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLCH2 | SNV | Missense_Mutation | novel | c.1369N>A | p.Pro457Thr | p.P457T | O75038 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
PLCH2 | SNV | Missense_Mutation | rs760790950 | c.544N>A | p.Asp182Asn | p.D182N | O75038 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLCH2 | SNV | Missense_Mutation | novel | c.728N>G | p.Asp243Gly | p.D243G | O75038 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLCH2 | SNV | Missense_Mutation | novel | c.1463N>G | p.Asp488Gly | p.D488G | O75038 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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