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Gene: PID1 |
Gene summary for PID1 |
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Gene information | Species | Human | Gene symbol | PID1 | Gene ID | 55022 |
Gene name | phosphotyrosine interaction domain containing 1 | |
Gene Alias | HMFN2073 | |
Cytomap | 2q36.3 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | Q7Z2X4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55022 | PID1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.27e-18 | -6.95e-01 | 0.0155 |
55022 | PID1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.75e-03 | -4.58e-01 | -0.1808 |
55022 | PID1 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.87e-12 | 7.05e-01 | -0.1954 |
55022 | PID1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.85e-08 | -7.99e-01 | -0.1207 |
55022 | PID1 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.41e-05 | -5.51e-01 | 0.096 |
55022 | PID1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.85e-02 | -7.30e-01 | 0.0446 |
55022 | PID1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 5.52e-04 | -7.72e-01 | 0.0528 |
55022 | PID1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.13e-07 | -7.06e-01 | 0.0338 |
55022 | PID1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.55e-20 | -6.83e-01 | 0.0674 |
55022 | PID1 | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.93e-03 | -3.82e-01 | -0.0124 |
55022 | PID1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.44e-44 | -9.88e-01 | 0.294 |
55022 | PID1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.41e-43 | -1.01e+00 | 0.3859 |
55022 | PID1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 8.46e-07 | -7.97e-01 | 0.2585 |
55022 | PID1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.35e-39 | -9.09e-01 | 0.3005 |
55022 | PID1 | A001-C-207 | Human | Colorectum | FAP | 3.23e-03 | -4.05e-01 | 0.1278 |
55022 | PID1 | A015-C-203 | Human | Colorectum | FAP | 1.39e-27 | -6.74e-01 | -0.1294 |
55022 | PID1 | A015-C-204 | Human | Colorectum | FAP | 7.98e-06 | -4.06e-01 | -0.0228 |
55022 | PID1 | A014-C-040 | Human | Colorectum | FAP | 8.80e-05 | -5.88e-01 | -0.1184 |
55022 | PID1 | A002-C-201 | Human | Colorectum | FAP | 2.51e-12 | -5.07e-01 | 0.0324 |
55022 | PID1 | A001-C-119 | Human | Colorectum | FAP | 9.03e-17 | -8.31e-01 | -0.1557 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0046034 | Colorectum | AD | ATP metabolic process | 142/3918 | 277/18723 | 2.64e-29 | 8.26e-26 | 142 |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0015980 | Colorectum | AD | energy derivation by oxidation of organic compounds | 143/3918 | 318/18723 | 2.78e-22 | 2.49e-19 | 143 |
GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
GO:0009150 | Colorectum | AD | purine ribonucleotide metabolic process | 142/3918 | 368/18723 | 4.29e-15 | 1.17e-12 | 142 |
GO:0006163 | Colorectum | AD | purine nucleotide metabolic process | 149/3918 | 396/18723 | 1.08e-14 | 2.80e-12 | 149 |
GO:0072521 | Colorectum | AD | purine-containing compound metabolic process | 153/3918 | 416/18723 | 4.34e-14 | 1.01e-11 | 153 |
GO:0009259 | Colorectum | AD | ribonucleotide metabolic process | 144/3918 | 385/18723 | 5.25e-14 | 1.13e-11 | 144 |
GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
GO:0019693 | Colorectum | AD | ribose phosphate metabolic process | 145/3918 | 396/18723 | 3.01e-13 | 5.71e-11 | 145 |
GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
GO:1905475 | Colorectum | AD | regulation of protein localization to membrane | 73/3918 | 175/18723 | 3.37e-10 | 2.93e-08 | 73 |
GO:0009144 | Colorectum | AD | purine nucleoside triphosphate metabolic process | 43/3918 | 88/18723 | 5.05e-09 | 3.19e-07 | 43 |
GO:1903076 | Colorectum | AD | regulation of protein localization to plasma membrane | 48/3918 | 104/18723 | 7.17e-09 | 4.36e-07 | 48 |
GO:1904375 | Colorectum | AD | regulation of protein localization to cell periphery | 54/3918 | 125/18723 | 1.52e-08 | 9.00e-07 | 54 |
GO:0009205 | Colorectum | AD | purine ribonucleoside triphosphate metabolic process | 39/3918 | 82/18723 | 6.58e-08 | 3.40e-06 | 39 |
GO:0009141 | Colorectum | AD | nucleoside triphosphate metabolic process | 48/3918 | 112/18723 | 1.27e-07 | 6.02e-06 | 48 |
GO:0006754 | Colorectum | AD | ATP biosynthetic process | 30/3918 | 57/18723 | 1.27e-07 | 6.02e-06 | 30 |
GO:0009145 | Colorectum | AD | purine nucleoside triphosphate biosynthetic process | 34/3918 | 69/18723 | 1.54e-07 | 6.78e-06 | 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PID1 | SNV | Missense_Mutation | c.740N>T | p.Ser247Phe | p.S247F | Q7Z2X4 | protein_coding | deleterious(0.01) | possibly_damaging(0.687) | TCGA-80-5611-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | SD | |
PID1 | SNV | Missense_Mutation | c.511G>A | p.Ala171Thr | p.A171T | Q7Z2X4 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
PID1 | SNV | Missense_Mutation | c.260C>G | p.Thr87Ser | p.T87S | Q7Z2X4 | protein_coding | tolerated_low_confidence(0.11) | benign(0.009) | TCGA-NC-A5HH-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PID1 | SNV | Missense_Mutation | c.740N>A | p.Ser247Tyr | p.S247Y | Q7Z2X4 | protein_coding | deleterious(0.01) | possibly_damaging(0.687) | TCGA-CN-A63U-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PID1 | SNV | Missense_Mutation | rs764931966 | c.494N>A | p.Arg165His | p.R165H | Q7Z2X4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EJ-8474-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | SD |
PID1 | SNV | Missense_Mutation | rs200100687 | c.392N>T | p.Pro131Leu | p.P131L | Q7Z2X4 | protein_coding | deleterious(0.01) | benign(0.307) | TCGA-V1-A8X3-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
PID1 | SNV | Missense_Mutation | novel | c.217N>A | p.Ala73Thr | p.A73T | Q7Z2X4 | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.494) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PID1 | SNV | Missense_Mutation | c.367A>G | p.Thr123Ala | p.T123A | Q7Z2X4 | protein_coding | tolerated(0.19) | benign(0.022) | TCGA-BR-4357-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
PID1 | SNV | Missense_Mutation | c.272G>A | p.Cys91Tyr | p.C91Y | Q7Z2X4 | protein_coding | tolerated_low_confidence(1) | benign(0.003) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PID1 | SNV | Missense_Mutation | rs766470127 | c.212C>T | p.Pro71Leu | p.P71L | Q7Z2X4 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.998) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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