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Gene: PHTF2 |
Gene summary for PHTF2 |
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Gene information | Species | Human | Gene symbol | PHTF2 | Gene ID | 57157 |
Gene name | putative homeodomain transcription factor 2 | |
Gene Alias | PHTF2 | |
Cytomap | 7q11.23-q21.11 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8N3S3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57157 | PHTF2 | LZE4T | Human | Esophagus | ESCC | 6.89e-05 | 2.68e-01 | 0.0811 |
57157 | PHTF2 | LZE7T | Human | Esophagus | ESCC | 3.19e-08 | 4.33e-01 | 0.0667 |
57157 | PHTF2 | LZE20T | Human | Esophagus | ESCC | 3.88e-02 | 9.49e-02 | 0.0662 |
57157 | PHTF2 | LZE24T | Human | Esophagus | ESCC | 6.95e-04 | 1.94e-01 | 0.0596 |
57157 | PHTF2 | LZE21T | Human | Esophagus | ESCC | 3.66e-04 | 1.95e-01 | 0.0655 |
57157 | PHTF2 | LZE6T | Human | Esophagus | ESCC | 3.64e-06 | 2.53e-01 | 0.0845 |
57157 | PHTF2 | P2T-E | Human | Esophagus | ESCC | 1.58e-13 | 2.32e-01 | 0.1177 |
57157 | PHTF2 | P4T-E | Human | Esophagus | ESCC | 1.71e-14 | 3.40e-01 | 0.1323 |
57157 | PHTF2 | P5T-E | Human | Esophagus | ESCC | 1.50e-07 | 1.51e-01 | 0.1327 |
57157 | PHTF2 | P8T-E | Human | Esophagus | ESCC | 1.03e-10 | 7.69e-02 | 0.0889 |
57157 | PHTF2 | P9T-E | Human | Esophagus | ESCC | 8.74e-09 | 2.01e-01 | 0.1131 |
57157 | PHTF2 | P10T-E | Human | Esophagus | ESCC | 8.09e-19 | 2.08e-01 | 0.116 |
57157 | PHTF2 | P11T-E | Human | Esophagus | ESCC | 6.41e-05 | 3.04e-01 | 0.1426 |
57157 | PHTF2 | P12T-E | Human | Esophagus | ESCC | 1.04e-05 | 2.65e-01 | 0.1122 |
57157 | PHTF2 | P15T-E | Human | Esophagus | ESCC | 6.39e-13 | 3.61e-01 | 0.1149 |
57157 | PHTF2 | P16T-E | Human | Esophagus | ESCC | 6.25e-35 | 5.67e-01 | 0.1153 |
57157 | PHTF2 | P17T-E | Human | Esophagus | ESCC | 2.90e-02 | 1.64e-01 | 0.1278 |
57157 | PHTF2 | P20T-E | Human | Esophagus | ESCC | 2.75e-14 | 2.94e-01 | 0.1124 |
57157 | PHTF2 | P21T-E | Human | Esophagus | ESCC | 6.16e-15 | 2.89e-01 | 0.1617 |
57157 | PHTF2 | P22T-E | Human | Esophagus | ESCC | 2.46e-14 | 3.10e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHTF2 | SNV | Missense_Mutation | c.1411N>A | p.Ala471Thr | p.A471T | Q8N3S3 | protein_coding | tolerated(0.08) | benign(0.045) | TCGA-BS-A0UM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
PHTF2 | SNV | Missense_Mutation | rs370027222 | c.941N>A | p.Arg314His | p.R314H | Q8N3S3 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PHTF2 | SNV | Missense_Mutation | novel | c.1088N>A | p.Arg363Lys | p.R363K | Q8N3S3 | protein_coding | deleterious(0.04) | probably_damaging(0.984) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PHTF2 | SNV | Missense_Mutation | c.94G>A | p.Glu32Lys | p.E32K | Q8N3S3 | protein_coding | tolerated(0.06) | possibly_damaging(0.64) | TCGA-D1-A16Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PHTF2 | SNV | Missense_Mutation | novel | c.1814C>G | p.Ala605Gly | p.A605G | Q8N3S3 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PHTF2 | SNV | Missense_Mutation | novel | c.1226C>A | p.Pro409His | p.P409H | Q8N3S3 | protein_coding | tolerated(0.54) | probably_damaging(0.999) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PHTF2 | SNV | Missense_Mutation | novel | c.303N>T | p.Lys101Asn | p.K101N | Q8N3S3 | protein_coding | tolerated(0.28) | benign(0.053) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PHTF2 | SNV | Missense_Mutation | novel | c.551N>T | p.Gly184Val | p.G184V | Q8N3S3 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PHTF2 | SNV | Missense_Mutation | novel | c.1949T>G | p.Phe650Cys | p.F650C | Q8N3S3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-DF-A2KV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PHTF2 | SNV | Missense_Mutation | c.503N>T | p.Arg168Ile | p.R168I | Q8N3S3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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