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Gene: PDE4DIP |
Gene summary for PDE4DIP |
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Gene information | Species | Human | Gene symbol | PDE4DIP | Gene ID | 9659 |
Gene name | phosphodiesterase 4D interacting protein | |
Gene Alias | CMYA2 | |
Cytomap | 1q21.2 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q5VU43 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9659 | PDE4DIP | LZE4T | Human | Esophagus | ESCC | 1.39e-02 | 1.40e-01 | 0.0811 |
9659 | PDE4DIP | LZE7T | Human | Esophagus | ESCC | 3.45e-05 | 2.75e-01 | 0.0667 |
9659 | PDE4DIP | LZE24T | Human | Esophagus | ESCC | 5.21e-12 | 3.25e-01 | 0.0596 |
9659 | PDE4DIP | LZE6T | Human | Esophagus | ESCC | 7.39e-03 | 2.08e-01 | 0.0845 |
9659 | PDE4DIP | P2T-E | Human | Esophagus | ESCC | 1.04e-16 | 3.31e-01 | 0.1177 |
9659 | PDE4DIP | P4T-E | Human | Esophagus | ESCC | 6.24e-13 | 2.97e-01 | 0.1323 |
9659 | PDE4DIP | P5T-E | Human | Esophagus | ESCC | 1.75e-07 | 1.92e-01 | 0.1327 |
9659 | PDE4DIP | P8T-E | Human | Esophagus | ESCC | 1.99e-16 | 1.81e-01 | 0.0889 |
9659 | PDE4DIP | P9T-E | Human | Esophagus | ESCC | 9.61e-13 | 3.19e-01 | 0.1131 |
9659 | PDE4DIP | P10T-E | Human | Esophagus | ESCC | 6.35e-41 | 6.94e-01 | 0.116 |
9659 | PDE4DIP | P11T-E | Human | Esophagus | ESCC | 9.72e-17 | 7.65e-01 | 0.1426 |
9659 | PDE4DIP | P12T-E | Human | Esophagus | ESCC | 1.53e-13 | 2.19e-01 | 0.1122 |
9659 | PDE4DIP | P15T-E | Human | Esophagus | ESCC | 6.54e-10 | 2.99e-01 | 0.1149 |
9659 | PDE4DIP | P16T-E | Human | Esophagus | ESCC | 4.58e-11 | 2.49e-01 | 0.1153 |
9659 | PDE4DIP | P17T-E | Human | Esophagus | ESCC | 2.44e-06 | 3.86e-01 | 0.1278 |
9659 | PDE4DIP | P19T-E | Human | Esophagus | ESCC | 3.41e-08 | 7.93e-01 | 0.1662 |
9659 | PDE4DIP | P20T-E | Human | Esophagus | ESCC | 1.05e-05 | 2.31e-01 | 0.1124 |
9659 | PDE4DIP | P21T-E | Human | Esophagus | ESCC | 2.42e-15 | 2.34e-01 | 0.1617 |
9659 | PDE4DIP | P22T-E | Human | Esophagus | ESCC | 1.07e-20 | 2.75e-01 | 0.1236 |
9659 | PDE4DIP | P23T-E | Human | Esophagus | ESCC | 8.93e-15 | 5.01e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00070308 | Esophagus | ESCC | Golgi organization | 101/8552 | 157/18723 | 1.78e-06 | 2.10e-05 | 101 |
GO:0007030 | Liver | NAFLD | Golgi organization | 36/1882 | 157/18723 | 1.76e-06 | 7.68e-05 | 36 |
GO:1903358 | Liver | NAFLD | regulation of Golgi organization | 7/1882 | 17/18723 | 8.03e-04 | 9.95e-03 | 7 |
GO:00070301 | Liver | Cirrhotic | Golgi organization | 68/4634 | 157/18723 | 2.57e-07 | 6.41e-06 | 68 |
GO:19033581 | Liver | Cirrhotic | regulation of Golgi organization | 10/4634 | 17/18723 | 2.85e-03 | 1.64e-02 | 10 |
GO:00070302 | Liver | HCC | Golgi organization | 99/7958 | 157/18723 | 1.54e-07 | 2.85e-06 | 99 |
GO:19033582 | Liver | HCC | regulation of Golgi organization | 13/7958 | 17/18723 | 4.77e-03 | 2.02e-02 | 13 |
GO:000703013 | Prostate | Tumor | Golgi organization | 40/3246 | 157/18723 | 6.33e-03 | 2.90e-02 | 40 |
GO:000703010 | Thyroid | PTC | Golgi organization | 79/5968 | 157/18723 | 1.11e-06 | 1.64e-05 | 79 |
GO:000703015 | Thyroid | ATC | Golgi organization | 79/6293 | 157/18723 | 1.07e-05 | 1.05e-04 | 79 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDE4DIP | SNV | Missense_Mutation | c.2779N>T | p.Arg927Cys | p.R927C | protein_coding | tolerated(0.19) | possibly_damaging(0.513) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | ||
PDE4DIP | SNV | Missense_Mutation | novel | c.1432C>T | p.Arg478Cys | p.R478C | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PDE4DIP | SNV | Missense_Mutation | novel | c.231G>T | p.Glu77Asp | p.E77D | protein_coding | deleterious(0) | probably_damaging(0.923) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PDE4DIP | SNV | Missense_Mutation | novel | c.1432C>T | p.Arg478Cys | p.R478C | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PDE4DIP | SNV | Missense_Mutation | c.1901G>A | p.Arg634Gln | p.R634Q | protein_coding | deleterious(0.01) | benign(0.416) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
PDE4DIP | SNV | Missense_Mutation | novel | c.6704G>T | p.Ser2235Ile | p.S2235I | protein_coding | deleterious(0.01) | possibly_damaging(0.631) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PDE4DIP | SNV | Missense_Mutation | c.4172N>A | p.Ser1391Asn | p.S1391N | protein_coding | deleterious(0.03) | probably_damaging(0.981) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
PDE4DIP | SNV | Missense_Mutation | c.3152N>T | p.Ser1051Ile | p.S1051I | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-DT-5265-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
PDE4DIP | SNV | Missense_Mutation | c.6770N>T | p.Ala2257Val | p.A2257V | protein_coding | tolerated(0.08) | possibly_damaging(0.769) | TCGA-EF-5831-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
PDE4DIP | SNV | Missense_Mutation | novel | c.2614N>T | p.Arg872Trp | p.R872W | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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