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Gene: OXCT1 |
Gene summary for OXCT1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | OXCT1 | Gene ID | 5019 |
Gene name | 3-oxoacid CoA-transferase 1 | |
Gene Alias | OXCT | |
Cytomap | 5p13.1 | |
Gene Type | protein-coding | GO ID | GO:0001678 | UniProtAcc | A0A024R040 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5019 | OXCT1 | LZE7T | Human | Esophagus | ESCC | 7.46e-03 | 3.61e-01 | 0.0667 |
5019 | OXCT1 | LZE8T | Human | Esophagus | ESCC | 3.34e-02 | 1.20e-01 | 0.067 |
5019 | OXCT1 | LZE22T | Human | Esophagus | ESCC | 1.12e-02 | 2.66e-01 | 0.068 |
5019 | OXCT1 | LZE24T | Human | Esophagus | ESCC | 5.87e-04 | 1.02e-01 | 0.0596 |
5019 | OXCT1 | LZE6T | Human | Esophagus | ESCC | 4.17e-07 | 3.82e-01 | 0.0845 |
5019 | OXCT1 | P1T-E | Human | Esophagus | ESCC | 6.56e-08 | 4.56e-01 | 0.0875 |
5019 | OXCT1 | P2T-E | Human | Esophagus | ESCC | 4.83e-21 | 4.25e-01 | 0.1177 |
5019 | OXCT1 | P4T-E | Human | Esophagus | ESCC | 7.46e-16 | 3.90e-01 | 0.1323 |
5019 | OXCT1 | P5T-E | Human | Esophagus | ESCC | 4.26e-12 | 1.95e-01 | 0.1327 |
5019 | OXCT1 | P8T-E | Human | Esophagus | ESCC | 3.60e-17 | 3.95e-01 | 0.0889 |
5019 | OXCT1 | P9T-E | Human | Esophagus | ESCC | 3.06e-07 | 1.20e-01 | 0.1131 |
5019 | OXCT1 | P10T-E | Human | Esophagus | ESCC | 2.34e-44 | 7.22e-01 | 0.116 |
5019 | OXCT1 | P11T-E | Human | Esophagus | ESCC | 2.43e-07 | 3.20e-01 | 0.1426 |
5019 | OXCT1 | P12T-E | Human | Esophagus | ESCC | 5.05e-23 | 4.03e-01 | 0.1122 |
5019 | OXCT1 | P15T-E | Human | Esophagus | ESCC | 1.56e-14 | 3.22e-01 | 0.1149 |
5019 | OXCT1 | P16T-E | Human | Esophagus | ESCC | 4.06e-27 | 4.51e-01 | 0.1153 |
5019 | OXCT1 | P17T-E | Human | Esophagus | ESCC | 9.99e-17 | 5.64e-01 | 0.1278 |
5019 | OXCT1 | P19T-E | Human | Esophagus | ESCC | 2.56e-04 | 3.36e-01 | 0.1662 |
5019 | OXCT1 | P20T-E | Human | Esophagus | ESCC | 2.88e-13 | 3.68e-01 | 0.1124 |
5019 | OXCT1 | P21T-E | Human | Esophagus | ESCC | 3.90e-23 | 4.36e-01 | 0.1617 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
GO:1904951111 | Esophagus | ESCC | positive regulation of establishment of protein localization | 216/8552 | 319/18723 | 1.01e-15 | 6.86e-14 | 216 |
GO:0051222111 | Esophagus | ESCC | positive regulation of protein transport | 204/8552 | 303/18723 | 1.56e-14 | 8.38e-13 | 204 |
GO:0031667111 | Esophagus | ESCC | response to nutrient levels | 289/8552 | 474/18723 | 9.25e-12 | 3.47e-10 | 289 |
GO:004259419 | Esophagus | ESCC | response to starvation | 133/8552 | 197/18723 | 4.31e-10 | 1.14e-08 | 133 |
GO:000758410 | Esophagus | ESCC | response to nutrient | 114/8552 | 174/18723 | 9.43e-08 | 1.56e-06 | 114 |
GO:000941020 | Esophagus | ESCC | response to xenobiotic stimulus | 253/8552 | 462/18723 | 4.55e-05 | 3.58e-04 | 253 |
GO:00421805 | Esophagus | ESCC | cellular ketone metabolic process | 120/8552 | 211/18723 | 6.70e-04 | 3.55e-03 | 120 |
GO:00442827 | Esophagus | ESCC | small molecule catabolic process | 201/8552 | 376/18723 | 1.35e-03 | 6.41e-03 | 201 |
GO:0097305111 | Esophagus | ESCC | response to alcohol | 138/8552 | 253/18723 | 2.70e-03 | 1.14e-02 | 138 |
GO:000930617 | Esophagus | ESCC | protein secretion | 190/8552 | 359/18723 | 3.22e-03 | 1.34e-02 | 190 |
GO:003559217 | Esophagus | ESCC | establishment of protein localization to extracellular region | 190/8552 | 360/18723 | 3.77e-03 | 1.53e-02 | 190 |
GO:007169210 | Esophagus | ESCC | protein localization to extracellular region | 193/8552 | 368/18723 | 5.01e-03 | 1.92e-02 | 193 |
GO:0009743111 | Esophagus | ESCC | response to carbohydrate | 135/8552 | 253/18723 | 8.16e-03 | 2.89e-02 | 135 |
GO:005070810 | Esophagus | ESCC | regulation of protein secretion | 142/8552 | 268/18723 | 9.31e-03 | 3.24e-02 | 142 |
GO:005071416 | Esophagus | ESCC | positive regulation of protein secretion | 76/8552 | 137/18723 | 1.32e-02 | 4.31e-02 | 76 |
GO:000609122 | Liver | HCC | generation of precursor metabolites and energy | 340/7958 | 490/18723 | 4.04e-34 | 2.85e-31 | 340 |
GO:190495122 | Liver | HCC | positive regulation of establishment of protein localization | 207/7958 | 319/18723 | 3.95e-16 | 3.29e-14 | 207 |
GO:005122222 | Liver | HCC | positive regulation of protein transport | 194/7958 | 303/18723 | 2.41e-14 | 1.56e-12 | 194 |
GO:003166722 | Liver | HCC | response to nutrient levels | 276/7958 | 474/18723 | 2.30e-12 | 1.08e-10 | 276 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa002809 | Esophagus | ESCC | Valine, leucine and isoleucine degradation | 34/4205 | 48/8465 | 2.34e-03 | 6.54e-03 | 3.35e-03 | 34 |
hsa0028014 | Esophagus | ESCC | Valine, leucine and isoleucine degradation | 34/4205 | 48/8465 | 2.34e-03 | 6.54e-03 | 3.35e-03 | 34 |
hsa002808 | Oral cavity | OSCC | Valine, leucine and isoleucine degradation | 30/3704 | 48/8465 | 6.75e-03 | 1.57e-02 | 7.99e-03 | 30 |
hsa0028013 | Oral cavity | OSCC | Valine, leucine and isoleucine degradation | 30/3704 | 48/8465 | 6.75e-03 | 1.57e-02 | 7.99e-03 | 30 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OXCT1 | SNV | Missense_Mutation | rs758116505 | c.833G>T | p.Arg278Ile | p.R278I | P55809 | protein_coding | deleterious(0.04) | probably_damaging(0.92) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
OXCT1 | SNV | Missense_Mutation | novel | c.806N>G | p.Leu269Arg | p.L269R | P55809 | protein_coding | deleterious(0) | probably_damaging(0.922) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OXCT1 | SNV | Missense_Mutation | c.1436N>G | p.Asp479Gly | p.D479G | P55809 | protein_coding | deleterious(0.01) | benign(0.185) | TCGA-EY-A1GV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | SD | |
OXCT1 | SNV | Missense_Mutation | novel | c.1545N>A | p.Met515Ile | p.M515I | P55809 | protein_coding | deleterious(0.03) | possibly_damaging(0.692) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
OXCT1 | SNV | Missense_Mutation | rs778813276 | c.1492G>A | p.Val498Ile | p.V498I | P55809 | protein_coding | tolerated(1) | benign(0.003) | TCGA-EY-A5W2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OXCT1 | deletion | Frame_Shift_Del | novel | c.89delN | p.Cys30PhefsTer18 | p.C30Ffs*18 | P55809 | protein_coding | TCGA-B5-A3F9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
OXCT1 | SNV | Missense_Mutation | rs748285289 | c.1300N>G | p.Lys434Glu | p.K434E | P55809 | protein_coding | tolerated(0.17) | benign(0.045) | TCGA-44-A4SU-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
OXCT1 | SNV | Missense_Mutation | c.901N>T | p.Val301Leu | p.V301L | P55809 | protein_coding | tolerated(0.65) | benign(0) | TCGA-49-4510-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
OXCT1 | SNV | Missense_Mutation | c.322A>T | p.Ile108Leu | p.I108L | P55809 | protein_coding | tolerated(0.13) | benign(0.063) | TCGA-50-5072-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
OXCT1 | SNV | Missense_Mutation | c.1423N>T | p.Val475Leu | p.V475L | P55809 | protein_coding | deleterious(0) | benign(0.125) | TCGA-86-8672-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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