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Gene: OSBPL9 |
Gene summary for OSBPL9 |
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Gene information | Species | Human | Gene symbol | OSBPL9 | Gene ID | 114883 |
Gene name | oxysterol binding protein like 9 | |
Gene Alias | ORP-9 | |
Cytomap | 1p32.3 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | Q96SU4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114883 | OSBPL9 | CCI_1 | Human | Cervix | CC | 5.49e-04 | 8.17e-01 | 0.528 |
114883 | OSBPL9 | CCI_3 | Human | Cervix | CC | 1.78e-10 | 7.20e-01 | 0.516 |
114883 | OSBPL9 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.44e-16 | -6.25e-01 | 0.0155 |
114883 | OSBPL9 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.96e-08 | -5.03e-01 | 0.096 |
114883 | OSBPL9 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.84e-07 | -5.94e-01 | 0.0338 |
114883 | OSBPL9 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.20e-03 | -3.80e-01 | 0.0674 |
114883 | OSBPL9 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.26e-02 | -4.66e-01 | 0.0588 |
114883 | OSBPL9 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.39e-05 | -3.71e-01 | 0.294 |
114883 | OSBPL9 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.25e-04 | -3.85e-01 | 0.3859 |
114883 | OSBPL9 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.39e-06 | -6.73e-01 | 0.2585 |
114883 | OSBPL9 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.20e-17 | -5.95e-01 | 0.3005 |
114883 | OSBPL9 | F007 | Human | Colorectum | FAP | 3.74e-05 | -4.91e-01 | 0.1176 |
114883 | OSBPL9 | A002-C-010 | Human | Colorectum | FAP | 2.05e-05 | -3.28e-01 | 0.242 |
114883 | OSBPL9 | A001-C-207 | Human | Colorectum | FAP | 2.82e-02 | -3.16e-01 | 0.1278 |
114883 | OSBPL9 | A015-C-203 | Human | Colorectum | FAP | 6.93e-27 | -4.88e-01 | -0.1294 |
114883 | OSBPL9 | A015-C-204 | Human | Colorectum | FAP | 8.04e-11 | -5.07e-01 | -0.0228 |
114883 | OSBPL9 | A014-C-040 | Human | Colorectum | FAP | 2.17e-06 | -5.39e-01 | -0.1184 |
114883 | OSBPL9 | A002-C-201 | Human | Colorectum | FAP | 3.89e-16 | -4.82e-01 | 0.0324 |
114883 | OSBPL9 | A002-C-203 | Human | Colorectum | FAP | 3.86e-06 | -2.76e-01 | 0.2786 |
114883 | OSBPL9 | A001-C-119 | Human | Colorectum | FAP | 6.61e-09 | -5.25e-01 | -0.1557 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0008202 | Colorectum | AD | steroid metabolic process | 85/3918 | 319/18723 | 8.07e-03 | 4.75e-02 | 85 |
GO:0046394 | Colorectum | MSS | carboxylic acid biosynthetic process | 76/3467 | 314/18723 | 6.71e-03 | 4.38e-02 | 76 |
GO:00108761 | Colorectum | MSS | lipid localization | 104/3467 | 448/18723 | 6.76e-03 | 4.38e-02 | 104 |
GO:0016053 | Colorectum | MSS | organic acid biosynthetic process | 76/3467 | 316/18723 | 7.88e-03 | 4.84e-02 | 76 |
GO:00068691 | Colorectum | FAP | lipid transport | 81/2622 | 398/18723 | 2.84e-04 | 3.76e-03 | 81 |
GO:00108762 | Colorectum | FAP | lipid localization | 85/2622 | 448/18723 | 1.92e-03 | 1.63e-02 | 85 |
GO:00068692 | Colorectum | CRC | lipid transport | 63/2078 | 398/18723 | 2.36e-03 | 2.26e-02 | 63 |
GO:00108763 | Colorectum | CRC | lipid localization | 68/2078 | 448/18723 | 4.60e-03 | 3.58e-02 | 68 |
GO:00463948 | Esophagus | ESCC | carboxylic acid biosynthetic process | 175/8552 | 314/18723 | 1.98e-04 | 1.26e-03 | 175 |
GO:00160538 | Esophagus | ESCC | organic acid biosynthetic process | 175/8552 | 316/18723 | 3.04e-04 | 1.82e-03 | 175 |
GO:00066946 | Esophagus | ESCC | steroid biosynthetic process | 98/8552 | 173/18723 | 2.34e-03 | 1.03e-02 | 98 |
GO:19016174 | Esophagus | ESCC | organic hydroxy compound biosynthetic process | 128/8552 | 237/18723 | 5.86e-03 | 2.16e-02 | 128 |
GO:00160535 | Liver | NAFLD | organic acid biosynthetic process | 77/1882 | 316/18723 | 1.03e-13 | 6.69e-11 | 77 |
GO:00463945 | Liver | NAFLD | carboxylic acid biosynthetic process | 75/1882 | 314/18723 | 6.37e-13 | 3.39e-10 | 75 |
GO:00082023 | Liver | NAFLD | steroid metabolic process | 69/1882 | 319/18723 | 5.90e-10 | 1.28e-07 | 69 |
GO:0008206 | Liver | NAFLD | bile acid metabolic process | 19/1882 | 49/18723 | 9.82e-08 | 7.76e-06 | 19 |
GO:00108765 | Liver | NAFLD | lipid localization | 79/1882 | 448/18723 | 4.75e-07 | 2.92e-05 | 79 |
GO:00723303 | Liver | NAFLD | monocarboxylic acid biosynthetic process | 46/1882 | 214/18723 | 5.06e-07 | 3.07e-05 | 46 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OSBPL9 | SNV | Missense_Mutation | novel | c.1687N>C | p.Tyr563His | p.Y563H | Q96SU4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
OSBPL9 | SNV | Missense_Mutation | c.1816C>G | p.Pro606Ala | p.P606A | Q96SU4 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-EO-A3KW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unspecific | SD | ||
OSBPL9 | SNV | Missense_Mutation | c.1130N>T | p.Ser377Phe | p.S377F | Q96SU4 | protein_coding | deleterious(0) | probably_damaging(0.949) | TCGA-ED-A8O5-01 | Liver | liver hepatocellular carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
OSBPL9 | SNV | Missense_Mutation | novel | c.713N>T | p.Gln238Leu | p.Q238L | Q96SU4 | protein_coding | tolerated(0.23) | benign(0.094) | TCGA-73-A9RS-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
OSBPL9 | SNV | Missense_Mutation | c.1580N>C | p.Ile527Thr | p.I527T | Q96SU4 | protein_coding | deleterious(0) | possibly_damaging(0.9) | TCGA-78-7154-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
OSBPL9 | SNV | Missense_Mutation | novel | c.1184N>T | p.Gly395Val | p.G395V | Q96SU4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OSBPL9 | SNV | Missense_Mutation | c.717G>T | p.Leu239Phe | p.L239F | Q96SU4 | protein_coding | tolerated(0.33) | benign(0.1) | TCGA-37-5819-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
OSBPL9 | SNV | Missense_Mutation | novel | c.733N>T | p.Arg245Cys | p.R245C | Q96SU4 | protein_coding | tolerated(0.08) | probably_damaging(0.983) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
OSBPL9 | SNV | Missense_Mutation | novel | c.1602G>C | p.Trp534Cys | p.W534C | Q96SU4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-90-7964-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
OSBPL9 | SNV | Missense_Mutation | rs371808604 | c.472N>C | p.Glu158Gln | p.E158Q | Q96SU4 | protein_coding | tolerated(0.08) | benign(0.085) | TCGA-BA-A6DE-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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