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Gene: OCLN |
Gene summary for OCLN |
Gene summary. |
Gene information | Species | Human | Gene symbol | OCLN | Gene ID | 100506658 |
Gene name | occludin | |
Gene Alias | BLCPMG | |
Cytomap | 5q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | A8K3T2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100506658 | OCLN | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.39e-14 | -5.77e-01 | 0.0155 |
100506658 | OCLN | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.22e-02 | -4.08e-01 | -0.1808 |
100506658 | OCLN | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.40e-03 | -4.28e-01 | -0.0811 |
100506658 | OCLN | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.78e-05 | -5.58e-01 | -0.1207 |
100506658 | OCLN | HTA11_696_2000001011 | Human | Colorectum | AD | 2.59e-07 | -3.96e-01 | -0.1464 |
100506658 | OCLN | HTA11_866_2000001011 | Human | Colorectum | AD | 6.82e-08 | -3.85e-01 | -0.1001 |
100506658 | OCLN | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.68e-02 | -4.12e-01 | -0.059 |
100506658 | OCLN | HTA11_546_2000001011 | Human | Colorectum | AD | 2.22e-03 | -5.48e-01 | -0.0842 |
100506658 | OCLN | HTA11_866_3004761011 | Human | Colorectum | AD | 5.77e-10 | -5.27e-01 | 0.096 |
100506658 | OCLN | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.62e-04 | -4.67e-01 | 0.0338 |
100506658 | OCLN | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.49e-19 | -5.49e-01 | 0.0674 |
100506658 | OCLN | HTA11_6818_2000001021 | Human | Colorectum | AD | 6.49e-06 | -5.96e-01 | 0.0588 |
100506658 | OCLN | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.17e-15 | -5.14e-01 | 0.294 |
100506658 | OCLN | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.60e-11 | -4.83e-01 | 0.3005 |
100506658 | OCLN | F007 | Human | Colorectum | FAP | 7.01e-03 | -2.93e-01 | 0.1176 |
100506658 | OCLN | A002-C-010 | Human | Colorectum | FAP | 1.92e-06 | -2.84e-01 | 0.242 |
100506658 | OCLN | A001-C-207 | Human | Colorectum | FAP | 2.02e-05 | -3.09e-01 | 0.1278 |
100506658 | OCLN | A015-C-203 | Human | Colorectum | FAP | 2.15e-33 | -5.06e-01 | -0.1294 |
100506658 | OCLN | A015-C-204 | Human | Colorectum | FAP | 1.60e-09 | -4.49e-01 | -0.0228 |
100506658 | OCLN | A014-C-040 | Human | Colorectum | FAP | 8.52e-07 | -5.51e-01 | -0.1184 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032271 | Colorectum | AD | regulation of protein polymerization | 94/3918 | 233/18723 | 1.01e-11 | 1.29e-09 | 94 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:1902905 | Colorectum | AD | positive regulation of supramolecular fiber organization | 85/3918 | 209/18723 | 5.95e-11 | 6.33e-09 | 85 |
GO:0051495 | Colorectum | AD | positive regulation of cytoskeleton organization | 89/3918 | 226/18723 | 1.61e-10 | 1.56e-08 | 89 |
GO:0032273 | Colorectum | AD | positive regulation of protein polymerization | 62/3918 | 138/18723 | 1.94e-10 | 1.76e-08 | 62 |
GO:0031334 | Colorectum | AD | positive regulation of protein-containing complex assembly | 91/3918 | 237/18723 | 4.78e-10 | 3.99e-08 | 91 |
GO:0045216 | Colorectum | AD | cell-cell junction organization | 80/3918 | 200/18723 | 5.57e-10 | 4.58e-08 | 80 |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:0007043 | Colorectum | AD | cell-cell junction assembly | 57/3918 | 146/18723 | 4.18e-07 | 1.61e-05 | 57 |
GO:0042060 | Colorectum | AD | wound healing | 128/3918 | 422/18723 | 2.73e-06 | 7.89e-05 | 128 |
GO:0043297 | Colorectum | AD | apical junction assembly | 34/3918 | 78/18723 | 5.31e-06 | 1.37e-04 | 34 |
GO:0010563 | Colorectum | AD | negative regulation of phosphorus metabolic process | 130/3918 | 442/18723 | 1.26e-05 | 2.76e-04 | 130 |
GO:0045936 | Colorectum | AD | negative regulation of phosphate metabolic process | 129/3918 | 441/18723 | 1.81e-05 | 3.76e-04 | 129 |
GO:1902743 | Colorectum | AD | regulation of lamellipodium organization | 25/3918 | 54/18723 | 2.63e-05 | 5.01e-04 | 25 |
GO:0120193 | Colorectum | AD | tight junction organization | 33/3918 | 80/18723 | 2.93e-05 | 5.42e-04 | 33 |
GO:0120192 | Colorectum | AD | tight junction assembly | 31/3918 | 74/18723 | 3.53e-05 | 6.43e-04 | 31 |
GO:1902745 | Colorectum | AD | positive regulation of lamellipodium organization | 19/3918 | 37/18723 | 4.08e-05 | 7.26e-04 | 19 |
GO:0097581 | Colorectum | AD | lamellipodium organization | 35/3918 | 90/18723 | 7.39e-05 | 1.18e-03 | 35 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04530 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa05130 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa05160 | Colorectum | AD | Hepatitis C | 54/2092 | 157/8465 | 3.87e-03 | 1.96e-02 | 1.25e-02 | 54 |
hsa04670 | Colorectum | AD | Leukocyte transendothelial migration | 41/2092 | 114/8465 | 4.60e-03 | 2.20e-02 | 1.40e-02 | 41 |
hsa045301 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa051301 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa051601 | Colorectum | AD | Hepatitis C | 54/2092 | 157/8465 | 3.87e-03 | 1.96e-02 | 1.25e-02 | 54 |
hsa046701 | Colorectum | AD | Leukocyte transendothelial migration | 41/2092 | 114/8465 | 4.60e-03 | 2.20e-02 | 1.40e-02 | 41 |
hsa045302 | Colorectum | SER | Tight junction | 59/1580 | 169/8465 | 3.24e-07 | 5.98e-06 | 4.34e-06 | 59 |
hsa051302 | Colorectum | SER | Pathogenic Escherichia coli infection | 60/1580 | 197/8465 | 3.63e-05 | 4.31e-04 | 3.13e-04 | 60 |
hsa046702 | Colorectum | SER | Leukocyte transendothelial migration | 37/1580 | 114/8465 | 2.77e-04 | 2.56e-03 | 1.86e-03 | 37 |
hsa045303 | Colorectum | SER | Tight junction | 59/1580 | 169/8465 | 3.24e-07 | 5.98e-06 | 4.34e-06 | 59 |
hsa051303 | Colorectum | SER | Pathogenic Escherichia coli infection | 60/1580 | 197/8465 | 3.63e-05 | 4.31e-04 | 3.13e-04 | 60 |
hsa046703 | Colorectum | SER | Leukocyte transendothelial migration | 37/1580 | 114/8465 | 2.77e-04 | 2.56e-03 | 1.86e-03 | 37 |
hsa045304 | Colorectum | MSS | Tight junction | 66/1875 | 169/8465 | 4.10e-07 | 6.25e-06 | 3.83e-06 | 66 |
hsa051304 | Colorectum | MSS | Pathogenic Escherichia coli infection | 73/1875 | 197/8465 | 1.10e-06 | 1.48e-05 | 9.06e-06 | 73 |
hsa051602 | Colorectum | MSS | Hepatitis C | 52/1875 | 157/8465 | 9.29e-04 | 5.58e-03 | 3.42e-03 | 52 |
hsa046704 | Colorectum | MSS | Leukocyte transendothelial migration | 36/1875 | 114/8465 | 1.21e-02 | 4.02e-02 | 2.46e-02 | 36 |
hsa045305 | Colorectum | MSS | Tight junction | 66/1875 | 169/8465 | 4.10e-07 | 6.25e-06 | 3.83e-06 | 66 |
hsa051305 | Colorectum | MSS | Pathogenic Escherichia coli infection | 73/1875 | 197/8465 | 1.10e-06 | 1.48e-05 | 9.06e-06 | 73 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
OCLN | OCLN | OCLN_OCLN | OCLN | CRC | AD |
OCLN | OCLN | OCLN_OCLN | OCLN | CRC | ADJ |
OCLN | OCLN | OCLN_OCLN | OCLN | CRC | CRC |
OCLN | OCLN | OCLN_OCLN | OCLN | CRC | FAP |
OCLN | OCLN | OCLN_OCLN | OCLN | CRC | Healthy |
OCLN | OCLN | OCLN_OCLN | OCLN | CRC | MSI-H |
OCLN | OCLN | OCLN_OCLN | OCLN | Endometrium | AEH |
OCLN | OCLN | OCLN_OCLN | OCLN | Endometrium | EEC |
OCLN | OCLN | OCLN_OCLN | OCLN | GC | ADJ |
OCLN | OCLN | OCLN_OCLN | OCLN | HNSCC | ADJ |
OCLN | OCLN | OCLN_OCLN | OCLN | HNSCC | OSCC |
OCLN | OCLN | OCLN_OCLN | OCLN | HNSCC | Precancer |
OCLN | OCLN | OCLN_OCLN | OCLN | Liver | HCC |
OCLN | OCLN | OCLN_OCLN | OCLN | Liver | Healthy |
OCLN | OCLN | OCLN_OCLN | OCLN | Liver | Precancer |
OCLN | OCLN | OCLN_OCLN | OCLN | Lung | AAH |
OCLN | OCLN | OCLN_OCLN | OCLN | Lung | IAC |
OCLN | OCLN | OCLN_OCLN | OCLN | Lung | MIAC |
OCLN | OCLN | OCLN_OCLN | OCLN | Prostate | BPH |
OCLN | OCLN | OCLN_OCLN | OCLN | Prostate | Healthy |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OCLN | SNV | Missense_Mutation | novel | c.224N>C | p.Met75Thr | p.M75T | Q16625 | protein_coding | deleterious(0) | possibly_damaging(0.751) | TCGA-43-2576-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
OCLN | SNV | Missense_Mutation | novel | c.1515N>A | p.Ser505Arg | p.S505R | Q16625 | protein_coding | deleterious(0.02) | probably_damaging(0.964) | TCGA-O2-A52V-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
OCLN | insertion | Frame_Shift_Ins | novel | c.672_673insC | p.Thr225HisfsTer51 | p.T225Hfs*51 | Q16625 | protein_coding | TCGA-21-1081-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
OCLN | SNV | Missense_Mutation | novel | c.1037N>T | p.Pro346Leu | p.P346L | Q16625 | protein_coding | deleterious(0.02) | possibly_damaging(0.728) | TCGA-B7-A5TI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | eloxatin | CR |
OCLN | SNV | Missense_Mutation | rs765029327 | c.437N>T | p.Ala146Val | p.A146V | Q16625 | protein_coding | tolerated(0.25) | probably_damaging(0.982) | TCGA-BR-7707-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OCLN | SNV | Missense_Mutation | c.815N>G | p.Asp272Gly | p.D272G | Q16625 | protein_coding | tolerated(0.64) | benign(0) | TCGA-BR-8295-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
OCLN | SNV | Missense_Mutation | c.559N>C | p.Phe187Leu | p.F187L | Q16625 | protein_coding | tolerated(1) | benign(0.055) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
OCLN | SNV | Missense_Mutation | rs757558128 | c.25C>T | p.Pro9Ser | p.P9S | Q16625 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
OCLN | SNV | Missense_Mutation | c.182C>A | p.Pro61His | p.P61H | Q16625 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
OCLN | SNV | Missense_Mutation | novel | c.1039N>A | p.Val347Ile | p.V347I | Q16625 | protein_coding | tolerated(0.36) | benign(0) | TCGA-IN-A6RI-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
100506658 | OCLN | DRUGGABLE GENOME, TRANSPORTER | RETINOIC ACID | 15500294 |
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