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Gene: NXPE1 |
Gene summary for NXPE1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NXPE1 | Gene ID | 120400 |
Gene name | neurexophilin and PC-esterase domain family member 1 | |
Gene Alias | FAM55A | |
Cytomap | 11q23.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8N323 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
120400 | NXPE1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.04e-05 | -4.93e-01 | 0.0155 |
120400 | NXPE1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.38e-03 | -3.04e-01 | -0.1808 |
120400 | NXPE1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 5.88e-17 | -1.33e+00 | 0.0216 |
120400 | NXPE1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.43e-25 | 1.39e+00 | -0.1954 |
120400 | NXPE1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.08e-19 | 8.18e-01 | -0.2602 |
120400 | NXPE1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.63e-05 | -5.81e-01 | -0.1207 |
120400 | NXPE1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.20e-06 | 2.31e-01 | -0.1464 |
120400 | NXPE1 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.82e-09 | 4.53e-01 | -0.1001 |
120400 | NXPE1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.84e-11 | -6.74e-01 | -0.059 |
120400 | NXPE1 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.19e-03 | 4.52e-01 | -0.0842 |
120400 | NXPE1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 5.66e-07 | 8.34e-01 | -0.0179 |
120400 | NXPE1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.55e-31 | -1.07e+00 | 0.096 |
120400 | NXPE1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.79e-02 | -2.78e-01 | 0.0446 |
120400 | NXPE1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 3.21e-12 | -1.47e+00 | 0.0451 |
120400 | NXPE1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.46e-02 | -6.84e-01 | 0.0528 |
120400 | NXPE1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 9.30e-05 | 5.91e-01 | -0.0177 |
120400 | NXPE1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 8.16e-07 | -1.05e+00 | 0.0171 |
120400 | NXPE1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.66e-21 | -1.02e+00 | 0.0338 |
120400 | NXPE1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.48e-26 | -7.11e-01 | 0.0674 |
120400 | NXPE1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 4.85e-13 | -8.91e-01 | 0.0112 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NXPE1 | SNV | Missense_Mutation | novel | c.859G>T | p.Asp287Tyr | p.D287Y | Q8N323 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-L4-A4E5-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NXPE1 | SNV | Missense_Mutation | rs763352009 | c.355N>T | p.Arg119Trp | p.R119W | Q8N323 | protein_coding | tolerated(0.13) | benign(0.037) | TCGA-L9-A743-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | taxotere | CR |
NXPE1 | SNV | Missense_Mutation | c.148N>A | p.Leu50Ile | p.L50I | Q8N323 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-22-4613-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NXPE1 | SNV | Missense_Mutation | novel | c.979N>G | p.Pro327Ala | p.P327A | Q8N323 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-56-8628-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NXPE1 | SNV | Missense_Mutation | novel | c.408N>T | p.Arg136Ser | p.R136S | Q8N323 | protein_coding | deleterious(0.03) | possibly_damaging(0.904) | TCGA-66-2763-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NXPE1 | SNV | Missense_Mutation | c.899T>G | p.Phe300Cys | p.F300C | Q8N323 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-66-2771-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR | |
NXPE1 | SNV | Missense_Mutation | novel | c.979C>A | p.Pro327Thr | p.P327T | Q8N323 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-85-7696-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NXPE1 | SNV | Missense_Mutation | novel | c.910N>T | p.Pro304Ser | p.P304S | Q8N323 | protein_coding | tolerated(0.08) | probably_damaging(0.967) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NXPE1 | SNV | Missense_Mutation | c.14N>G | p.Ala5Gly | p.A5G | Q8N323 | protein_coding | tolerated(0.12) | benign(0.071) | TCGA-96-7544-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NXPE1 | insertion | Frame_Shift_Ins | novel | c.201_202insT | p.Val68CysfsTer2 | p.V68Cfs*2 | Q8N323 | protein_coding | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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