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Gene: NPR3 |
Gene summary for NPR3 |
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Gene information | Species | Human | Gene symbol | NPR3 | Gene ID | 4883 |
Gene name | natriuretic peptide receptor 3 | |
Gene Alias | ANP-C | |
Cytomap | 5p13.3 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | P17342 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4883 | NPR3 | P5T-E | Human | Esophagus | ESCC | 1.43e-08 | 2.58e-01 | 0.1327 |
4883 | NPR3 | P10T-E | Human | Esophagus | ESCC | 1.20e-02 | 1.77e-02 | 0.116 |
4883 | NPR3 | P12T-E | Human | Esophagus | ESCC | 1.80e-37 | 9.47e-01 | 0.1122 |
4883 | NPR3 | P23T-E | Human | Esophagus | ESCC | 5.75e-08 | 5.33e-01 | 0.108 |
4883 | NPR3 | P26T-E | Human | Esophagus | ESCC | 1.32e-07 | 2.27e-01 | 0.1276 |
4883 | NPR3 | P27T-E | Human | Esophagus | ESCC | 1.06e-10 | 3.03e-01 | 0.1055 |
4883 | NPR3 | P28T-E | Human | Esophagus | ESCC | 3.60e-13 | 2.87e-01 | 0.1149 |
4883 | NPR3 | P31T-E | Human | Esophagus | ESCC | 3.12e-09 | 3.20e-01 | 0.1251 |
4883 | NPR3 | P32T-E | Human | Esophagus | ESCC | 4.94e-03 | 1.74e-01 | 0.1666 |
4883 | NPR3 | P39T-E | Human | Esophagus | ESCC | 1.02e-10 | 2.16e-01 | 0.0894 |
4883 | NPR3 | P42T-E | Human | Esophagus | ESCC | 1.72e-07 | 4.62e-01 | 0.1175 |
4883 | NPR3 | P54T-E | Human | Esophagus | ESCC | 1.35e-06 | 1.81e-01 | 0.0975 |
4883 | NPR3 | P62T-E | Human | Esophagus | ESCC | 2.06e-05 | 2.56e-01 | 0.1302 |
4883 | NPR3 | P74T-E | Human | Esophagus | ESCC | 8.75e-03 | 6.22e-02 | 0.1479 |
4883 | NPR3 | P83T-E | Human | Esophagus | ESCC | 2.21e-27 | 8.39e-01 | 0.1738 |
4883 | NPR3 | P84T-E | Human | Esophagus | ESCC | 2.73e-04 | 5.67e-01 | 0.0933 |
4883 | NPR3 | P107T-E | Human | Esophagus | ESCC | 1.17e-07 | 3.67e-01 | 0.171 |
4883 | NPR3 | P128T-E | Human | Esophagus | ESCC | 5.86e-15 | 8.06e-01 | 0.1241 |
4883 | NPR3 | P130T-E | Human | Esophagus | ESCC | 1.04e-04 | 3.92e-01 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00486597 | Esophagus | ESCC | smooth muscle cell proliferation | 103/8552 | 184/18723 | 3.08e-03 | 1.28e-02 | 103 |
GO:00486607 | Esophagus | ESCC | regulation of smooth muscle cell proliferation | 100/8552 | 180/18723 | 4.76e-03 | 1.85e-02 | 100 |
GO:00330025 | Esophagus | ESCC | muscle cell proliferation | 134/8552 | 248/18723 | 4.80e-03 | 1.86e-02 | 134 |
GO:00513534 | Esophagus | ESCC | positive regulation of oxidoreductase activity | 37/8552 | 59/18723 | 6.23e-03 | 2.29e-02 | 37 |
GO:01061066 | Esophagus | ESCC | cold-induced thermogenesis | 80/8552 | 144/18723 | 1.07e-02 | 3.65e-02 | 80 |
GO:01201616 | Esophagus | ESCC | regulation of cold-induced thermogenesis | 80/8552 | 144/18723 | 1.07e-02 | 3.65e-02 | 80 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NPR3 | SNV | Missense_Mutation | c.1211N>A | p.Val404Glu | p.V404E | P17342 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-78-7542-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NPR3 | SNV | Missense_Mutation | c.1184N>T | p.Arg395Ile | p.R395I | P17342 | protein_coding | deleterious(0) | possibly_damaging(0.677) | TCGA-86-8359-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
NPR3 | SNV | Missense_Mutation | c.1276G>C | p.Ala426Pro | p.A426P | P17342 | protein_coding | deleterious(0.03) | benign(0.324) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
NPR3 | SNV | Missense_Mutation | novel | c.1465G>T | p.Val489Leu | p.V489L | P17342 | protein_coding | tolerated(0.52) | probably_damaging(0.988) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
NPR3 | SNV | Missense_Mutation | c.995N>C | p.Phe332Ser | p.F332S | P17342 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-97-7938-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NPR3 | SNV | Missense_Mutation | c.631N>T | p.Arg211Trp | p.R211W | P17342 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-99-8025-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | gemzar | SD | |
NPR3 | SNV | Missense_Mutation | c.1276N>T | p.Ala426Ser | p.A426S | P17342 | protein_coding | tolerated(0.53) | benign(0.007) | TCGA-21-5786-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
NPR3 | SNV | Missense_Mutation | rs373722650 | c.1169N>G | p.Gln390Arg | p.Q390R | P17342 | protein_coding | tolerated(0.52) | benign(0.036) | TCGA-33-4566-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NPR3 | SNV | Missense_Mutation | novel | c.1327N>C | p.Glu443Gln | p.E443Q | P17342 | protein_coding | tolerated(0.33) | benign(0) | TCGA-43-A56U-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NPR3 | SNV | Missense_Mutation | c.1179G>T | p.Trp393Cys | p.W393C | P17342 | protein_coding | deleterious(0) | possibly_damaging(0.832) | TCGA-66-2756-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4883 | NPR3 | DRUGGABLE GENOME | agonist | 178101592 | ||
4883 | NPR3 | DRUGGABLE GENOME | antagonist | 178101571 | ||
4883 | NPR3 | DRUGGABLE GENOME | antagonist | 178101717 | ||
4883 | NPR3 | DRUGGABLE GENOME | CARDIODILATIN | |||
4883 | NPR3 | DRUGGABLE GENOME | ANX-042 | 23694773 | ||
4883 | NPR3 | DRUGGABLE GENOME | antagonist | 178101732 | ||
4883 | NPR3 | DRUGGABLE GENOME | 178101546 | |||
4883 | NPR3 | DRUGGABLE GENOME | agonist | 315661152 | PL-3994 | |
4883 | NPR3 | DRUGGABLE GENOME | NESIRITIDE | NESIRITIDE | ||
4883 | NPR3 | DRUGGABLE GENOME | NESIRITIDE | NESIRITIDE |
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