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Gene: NONO |
Gene summary for NONO |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | NONO | Gene ID | 4841 |
| Gene name | non-POU domain containing octamer binding | |
| Gene Alias | MRXS34 | |
| Cytomap | Xq13.1 | |
| Gene Type | protein-coding | GO ID | GO:0002218 | UniProtAcc | A0A0S2Z4Z9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 4841 | NONO | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.23e-13 | 4.33e-01 | 0.0155 |
| 4841 | NONO | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.46e-03 | 4.21e-01 | -0.1808 |
| 4841 | NONO | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.35e-06 | 6.96e-01 | 0.0216 |
| 4841 | NONO | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.14e-12 | 7.21e-01 | -0.0811 |
| 4841 | NONO | HTA11_78_2000001011 | Human | Colorectum | AD | 1.23e-15 | 5.48e-01 | -0.1088 |
| 4841 | NONO | HTA11_347_2000001011 | Human | Colorectum | AD | 1.65e-21 | 7.20e-01 | -0.1954 |
| 4841 | NONO | HTA11_411_2000001011 | Human | Colorectum | SER | 2.90e-02 | 7.13e-01 | -0.2602 |
| 4841 | NONO | HTA11_83_2000001011 | Human | Colorectum | SER | 1.13e-02 | 2.55e-01 | -0.1526 |
| 4841 | NONO | HTA11_696_2000001011 | Human | Colorectum | AD | 1.05e-15 | 5.04e-01 | -0.1464 |
| 4841 | NONO | HTA11_866_2000001011 | Human | Colorectum | AD | 3.72e-06 | 3.65e-01 | -0.1001 |
| 4841 | NONO | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.04e-24 | 9.97e-01 | -0.059 |
| 4841 | NONO | HTA11_546_2000001011 | Human | Colorectum | AD | 5.56e-10 | 6.28e-01 | -0.0842 |
| 4841 | NONO | HTA11_7862_2000001011 | Human | Colorectum | AD | 9.41e-12 | 7.72e-01 | -0.0179 |
| 4841 | NONO | HTA11_866_3004761011 | Human | Colorectum | AD | 3.85e-39 | 1.18e+00 | 0.096 |
| 4841 | NONO | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.21e-07 | 7.89e-01 | 0.0446 |
| 4841 | NONO | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.25e-11 | 9.43e-01 | 0.0528 |
| 4841 | NONO | HTA11_7663_2000001011 | Human | Colorectum | SER | 9.88e-12 | 9.21e-01 | 0.0131 |
| 4841 | NONO | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.22e-08 | 7.20e-01 | -0.0177 |
| 4841 | NONO | HTA11_6801_2000001011 | Human | Colorectum | SER | 3.65e-14 | 1.17e+00 | 0.0171 |
| 4841 | NONO | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.80e-07 | 5.53e-01 | 0.0338 |
| Page: 1 2 3 4 5 6 7 8 9 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
| GO:0097193 | Colorectum | AD | intrinsic apoptotic signaling pathway | 108/3918 | 288/18723 | 6.25e-11 | 6.41e-09 | 108 |
| GO:2001242 | Colorectum | AD | regulation of intrinsic apoptotic signaling pathway | 67/3918 | 164/18723 | 4.94e-09 | 3.16e-07 | 67 |
| GO:0006979 | Colorectum | AD | response to oxidative stress | 145/3918 | 446/18723 | 5.16e-09 | 3.23e-07 | 145 |
| GO:2001233 | Colorectum | AD | regulation of apoptotic signaling pathway | 119/3918 | 356/18723 | 2.14e-08 | 1.21e-06 | 119 |
| GO:0062197 | Colorectum | AD | cellular response to chemical stress | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
| GO:0070997 | Colorectum | AD | neuron death | 114/3918 | 361/18723 | 1.13e-06 | 3.72e-05 | 114 |
| GO:0034599 | Colorectum | AD | cellular response to oxidative stress | 94/3918 | 288/18723 | 2.03e-06 | 6.02e-05 | 94 |
| GO:0007623 | Colorectum | AD | circadian rhythm | 72/3918 | 210/18723 | 4.50e-06 | 1.21e-04 | 72 |
| GO:0048511 | Colorectum | AD | rhythmic process | 94/3918 | 298/18723 | 1.00e-05 | 2.34e-04 | 94 |
| GO:1901214 | Colorectum | AD | regulation of neuron death | 99/3918 | 319/18723 | 1.26e-05 | 2.76e-04 | 99 |
| GO:2001234 | Colorectum | AD | negative regulation of apoptotic signaling pathway | 74/3918 | 224/18723 | 1.49e-05 | 3.18e-04 | 74 |
| GO:2001243 | Colorectum | AD | negative regulation of intrinsic apoptotic signaling pathway | 39/3918 | 98/18723 | 1.58e-05 | 3.34e-04 | 39 |
| GO:0008631 | Colorectum | AD | intrinsic apoptotic signaling pathway in response to oxidative stress | 22/3918 | 45/18723 | 2.77e-05 | 5.24e-04 | 22 |
| GO:1902175 | Colorectum | AD | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | 16/3918 | 29/18723 | 5.32e-05 | 9.01e-04 | 16 |
| GO:0051402 | Colorectum | AD | neuron apoptotic process | 77/3918 | 246/18723 | 8.07e-05 | 1.28e-03 | 77 |
| GO:1901215 | Colorectum | AD | negative regulation of neuron death | 67/3918 | 208/18723 | 8.81e-05 | 1.35e-03 | 67 |
| GO:0036473 | Colorectum | AD | cell death in response to oxidative stress | 35/3918 | 95/18723 | 2.58e-04 | 3.24e-03 | 35 |
| GO:1903203 | Colorectum | AD | regulation of oxidative stress-induced neuron death | 14/3918 | 27/18723 | 3.72e-04 | 4.29e-03 | 14 |
| GO:1903204 | Colorectum | AD | negative regulation of oxidative stress-induced neuron death | 11/3918 | 19/18723 | 4.66e-04 | 5.15e-03 | 11 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| NONO | STM | Liver | Cirrhotic | MFSD9,HNRNPU,LCMT1, etc. | 4.68e-01 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| NONO | SNV | Missense_Mutation | novel | c.403C>T | p.Arg135Cys | p.R135C | Q15233 | protein_coding | tolerated(0.07) | benign(0.014) | TCGA-BG-A221-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| NONO | SNV | Missense_Mutation | novel | c.1112N>G | p.Lys371Arg | p.K371R | Q15233 | protein_coding | tolerated(0.36) | benign(0.01) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| NONO | SNV | Missense_Mutation | c.30N>T | p.Glu10Asp | p.E10D | Q15233 | protein_coding | tolerated_low_confidence(0.1) | benign(0) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| NONO | SNV | Missense_Mutation | c.304N>A | p.Glu102Lys | p.E102K | Q15233 | protein_coding | deleterious(0.01) | benign(0.159) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| NONO | SNV | Missense_Mutation | c.665N>G | p.Val222Gly | p.V222G | Q15233 | protein_coding | deleterious(0) | possibly_damaging(0.833) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| NONO | SNV | Missense_Mutation | c.344N>A | p.Arg115His | p.R115H | Q15233 | protein_coding | tolerated(0.08) | benign(0.061) | TCGA-D1-A168-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| NONO | SNV | Missense_Mutation | novel | c.770N>C | p.Phe257Ser | p.F257S | Q15233 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
| NONO | SNV | Missense_Mutation | c.878G>A | p.Arg293His | p.R293H | Q15233 | protein_coding | tolerated(0.14) | benign(0.001) | TCGA-D1-A17D-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
| NONO | SNV | Missense_Mutation | c.585N>A | p.Phe195Leu | p.F195L | Q15233 | protein_coding | deleterious(0.03) | benign(0.302) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| NONO | SNV | Missense_Mutation | c.1094N>A | p.Arg365Gln | p.R365Q | Q15233 | protein_coding | tolerated(0.16) | benign(0.216) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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