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Gene: NCSTN |
Gene summary for NCSTN |
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Gene information | Species | Human | Gene symbol | NCSTN | Gene ID | 23385 |
Gene name | nicastrin | |
Gene Alias | ATAG1874 | |
Cytomap | 1q23.2 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q92542 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23385 | NCSTN | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.46e-05 | 1.99e-01 | 0.0155 |
23385 | NCSTN | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.53e-08 | 4.19e-01 | -0.1808 |
23385 | NCSTN | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.93e-02 | 4.21e-01 | 0.0216 |
23385 | NCSTN | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.14e-06 | 3.67e-01 | -0.0811 |
23385 | NCSTN | HTA11_78_2000001011 | Human | Colorectum | AD | 5.38e-05 | 2.38e-01 | -0.1088 |
23385 | NCSTN | HTA11_347_2000001011 | Human | Colorectum | AD | 1.21e-19 | 4.60e-01 | -0.1954 |
23385 | NCSTN | HTA11_411_2000001011 | Human | Colorectum | SER | 3.59e-02 | 7.59e-01 | -0.2602 |
23385 | NCSTN | HTA11_83_2000001011 | Human | Colorectum | SER | 1.61e-02 | 3.25e-01 | -0.1526 |
23385 | NCSTN | HTA11_696_2000001011 | Human | Colorectum | AD | 2.53e-10 | 3.70e-01 | -0.1464 |
23385 | NCSTN | HTA11_866_2000001011 | Human | Colorectum | AD | 5.89e-05 | 1.96e-01 | -0.1001 |
23385 | NCSTN | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.89e-08 | 4.70e-01 | -0.059 |
23385 | NCSTN | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.13e-06 | 4.39e-01 | -0.2061 |
23385 | NCSTN | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.03e-02 | 3.21e-01 | -0.1462 |
23385 | NCSTN | HTA11_866_3004761011 | Human | Colorectum | AD | 3.81e-06 | 3.41e-01 | 0.096 |
23385 | NCSTN | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.19e-03 | 3.99e-01 | 0.0528 |
23385 | NCSTN | HTA11_10623_2000001011 | Human | Colorectum | AD | 7.04e-04 | 3.60e-01 | -0.0177 |
23385 | NCSTN | HTA11_6801_2000001011 | Human | Colorectum | SER | 8.81e-04 | 4.54e-01 | 0.0171 |
23385 | NCSTN | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.89e-02 | 2.60e-01 | 0.0338 |
23385 | NCSTN | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.46e-12 | 3.84e-01 | 0.0674 |
23385 | NCSTN | HTA11_7469_2000001011 | Human | Colorectum | AD | 4.79e-02 | 5.44e-01 | -0.0124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0045862 | Colorectum | AD | positive regulation of proteolysis | 129/3918 | 372/18723 | 4.04e-10 | 3.46e-08 | 129 |
GO:0070997 | Colorectum | AD | neuron death | 114/3918 | 361/18723 | 1.13e-06 | 3.72e-05 | 114 |
GO:0052547 | Colorectum | AD | regulation of peptidase activity | 137/3918 | 461/18723 | 4.12e-06 | 1.12e-04 | 137 |
GO:0002262 | Colorectum | AD | myeloid cell homeostasis | 57/3918 | 157/18723 | 6.17e-06 | 1.56e-04 | 57 |
GO:0010952 | Colorectum | AD | positive regulation of peptidase activity | 68/3918 | 197/18723 | 6.30e-06 | 1.59e-04 | 68 |
GO:0048872 | Colorectum | AD | homeostasis of number of cells | 87/3918 | 272/18723 | 1.16e-05 | 2.61e-04 | 87 |
GO:0052548 | Colorectum | AD | regulation of endopeptidase activity | 124/3918 | 432/18723 | 6.58e-05 | 1.07e-03 | 124 |
GO:0051402 | Colorectum | AD | neuron apoptotic process | 77/3918 | 246/18723 | 8.07e-05 | 1.28e-03 | 77 |
GO:0010950 | Colorectum | AD | positive regulation of endopeptidase activity | 59/3918 | 179/18723 | 1.11e-04 | 1.65e-03 | 59 |
GO:0010038 | Colorectum | AD | response to metal ion | 106/3918 | 373/18723 | 3.22e-04 | 3.83e-03 | 106 |
GO:0071248 | Colorectum | AD | cellular response to metal ion | 61/3918 | 197/18723 | 5.74e-04 | 6.09e-03 | 61 |
GO:0051604 | Colorectum | AD | protein maturation | 85/3918 | 294/18723 | 6.73e-04 | 6.91e-03 | 85 |
GO:0071241 | Colorectum | AD | cellular response to inorganic substance | 68/3918 | 226/18723 | 6.98e-04 | 7.10e-03 | 68 |
GO:0050673 | Colorectum | AD | epithelial cell proliferation | 119/3918 | 437/18723 | 8.75e-04 | 8.51e-03 | 119 |
GO:0033619 | Colorectum | AD | membrane protein proteolysis | 21/3918 | 57/18723 | 4.16e-03 | 2.88e-02 | 21 |
GO:0016485 | Colorectum | AD | protein processing | 63/3918 | 225/18723 | 6.77e-03 | 4.19e-02 | 63 |
GO:0007219 | Colorectum | AD | Notch signaling pathway | 50/3918 | 172/18723 | 6.92e-03 | 4.26e-02 | 50 |
GO:00458621 | Colorectum | SER | positive regulation of proteolysis | 106/2897 | 372/18723 | 8.40e-11 | 1.20e-08 | 106 |
GO:00525471 | Colorectum | SER | regulation of peptidase activity | 114/2897 | 461/18723 | 1.18e-07 | 7.17e-06 | 114 |
GO:00525481 | Colorectum | SER | regulation of endopeptidase activity | 103/2897 | 432/18723 | 2.86e-06 | 1.16e-04 | 103 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05010 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa050101 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa050102 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050103 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050104 | Colorectum | MSS | Alzheimer disease | 169/1875 | 384/8465 | 1.21e-22 | 1.01e-20 | 6.21e-21 | 169 |
hsa050105 | Colorectum | MSS | Alzheimer disease | 169/1875 | 384/8465 | 1.21e-22 | 1.01e-20 | 6.21e-21 | 169 |
hsa05010210 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa043306 | Esophagus | ESCC | Notch signaling pathway | 42/4205 | 62/8465 | 2.97e-03 | 7.97e-03 | 4.08e-03 | 42 |
hsa0501038 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa0433013 | Esophagus | ESCC | Notch signaling pathway | 42/4205 | 62/8465 | 2.97e-03 | 7.97e-03 | 4.08e-03 | 42 |
hsa0501014 | Liver | Cirrhotic | Alzheimer disease | 180/2530 | 384/8465 | 5.52e-13 | 1.36e-11 | 8.36e-12 | 180 |
hsa0501015 | Liver | Cirrhotic | Alzheimer disease | 180/2530 | 384/8465 | 5.52e-13 | 1.36e-11 | 8.36e-12 | 180 |
hsa0501022 | Liver | HCC | Alzheimer disease | 254/4020 | 384/8465 | 3.75e-14 | 8.97e-13 | 4.99e-13 | 254 |
hsa0501032 | Liver | HCC | Alzheimer disease | 254/4020 | 384/8465 | 3.75e-14 | 8.97e-13 | 4.99e-13 | 254 |
hsa0501028 | Oral cavity | OSCC | Alzheimer disease | 244/3704 | 384/8465 | 1.18e-15 | 3.60e-14 | 1.83e-14 | 244 |
hsa043305 | Oral cavity | OSCC | Notch signaling pathway | 44/3704 | 62/8465 | 1.26e-05 | 5.55e-05 | 2.83e-05 | 44 |
hsa05010112 | Oral cavity | OSCC | Alzheimer disease | 244/3704 | 384/8465 | 1.18e-15 | 3.60e-14 | 1.83e-14 | 244 |
hsa0433012 | Oral cavity | OSCC | Notch signaling pathway | 44/3704 | 62/8465 | 1.26e-05 | 5.55e-05 | 2.83e-05 | 44 |
hsa0501029 | Oral cavity | LP | Alzheimer disease | 197/2418 | 384/8465 | 6.66e-22 | 3.69e-20 | 2.38e-20 | 197 |
hsa0501037 | Oral cavity | LP | Alzheimer disease | 197/2418 | 384/8465 | 6.66e-22 | 3.69e-20 | 2.38e-20 | 197 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NCSTN | SNV | Missense_Mutation | novel | c.1390N>C | p.Asn464His | p.N464H | Q92542 | protein_coding | tolerated(0.12) | benign(0.086) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NCSTN | SNV | Missense_Mutation | novel | c.599N>G | p.Asn200Ser | p.N200S | Q92542 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2Y-A9H8-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Targeted Molecular therapy | sorafenib | PD |
NCSTN | SNV | Missense_Mutation | c.1433A>T | p.Asn478Ile | p.N478I | Q92542 | protein_coding | tolerated(0.12) | benign(0.079) | TCGA-ED-A459-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Ancillary | alvesin | CR | |
NCSTN | SNV | Missense_Mutation | c.1232N>G | p.Val411Gly | p.V411G | Q92542 | protein_coding | deleterious(0.02) | probably_damaging(0.966) | TCGA-ED-A7PZ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NCSTN | SNV | Missense_Mutation | c.1651C>T | p.Leu551Phe | p.L551F | Q92542 | protein_coding | tolerated(0.35) | benign(0.163) | TCGA-05-4410-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NCSTN | SNV | Missense_Mutation | c.1882N>T | p.Ala628Ser | p.A628S | Q92542 | protein_coding | tolerated(1) | benign(0) | TCGA-05-5425-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | gefitinib | PD | |
NCSTN | SNV | Missense_Mutation | c.1195N>T | p.Ala399Ser | p.A399S | Q92542 | protein_coding | tolerated(1) | benign(0.006) | TCGA-44-3918-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
NCSTN | SNV | Missense_Mutation | c.417G>T | p.Gln139His | p.Q139H | Q92542 | protein_coding | tolerated(0.09) | benign(0) | TCGA-44-7660-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Vaccine | recprame+as15 | PD | |
NCSTN | SNV | Missense_Mutation | novel | c.96N>T | p.Arg32Ser | p.R32S | Q92542 | protein_coding | tolerated(0.77) | benign(0) | TCGA-44-7662-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NCSTN | SNV | Missense_Mutation | rs374951668 | c.1172N>A | p.Arg391Gln | p.R391Q | Q92542 | protein_coding | tolerated(0.75) | benign(0.007) | TCGA-44-8119-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23385 | NCSTN | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | inhibitor | MK0752 | ||
23385 | NCSTN | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | inhibitor | RO 4929097 | ||
23385 | NCSTN | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | inhibitor | PF03084014 | ||
23385 | NCSTN | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | BMS-299897 | CHEMBL247471 | ||
23385 | NCSTN | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | IC261 | IC261 | 20350806 | |
23385 | NCSTN | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | GSI-136 | GSI-136 | ||
23385 | NCSTN | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | inhibitor | CHEMBL463981 | BEGACESTAT | |
23385 | NCSTN | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | modulator | CHEMBL190083 | TARENFLURBIL | |
23385 | NCSTN | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | inhibitor | CHEMBL520733 | SEMAGACESTAT | |
23385 | NCSTN | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | inhibitor | MK0752 |
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