![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: NBPF9 |
Gene summary for NBPF9 |
![]() |
Gene information | Species | Human | Gene symbol | NBPF9 | Gene ID | 400818 |
Gene name | NBPF member 9 | |
Gene Alias | AE01 | |
Cytomap | 1q21.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A087WY26 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
400818 | NBPF9 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.65e-02 | 1.27e-01 | 0.0155 |
400818 | NBPF9 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.81e-05 | 4.44e-01 | -0.1088 |
400818 | NBPF9 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.26e-14 | 5.03e-01 | -0.1954 |
400818 | NBPF9 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.48e-02 | 2.06e-01 | 0.096 |
400818 | NBPF9 | HTA11_6818_2000001011 | Human | Colorectum | AD | 3.55e-02 | 3.44e-01 | 0.0112 |
400818 | NBPF9 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.29e-12 | 5.34e-01 | 0.294 |
400818 | NBPF9 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.86e-05 | 1.03e+00 | 0.3487 |
400818 | NBPF9 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.32e-13 | 5.16e-01 | 0.3859 |
400818 | NBPF9 | A015-C-104 | Human | Colorectum | FAP | 7.38e-03 | 1.45e-01 | -0.1899 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NBPF9 | SNV | Missense_Mutation | novel | c.3269N>T | p.Arg1090Met | p.R1090M | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.988) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NBPF9 | insertion | Frame_Shift_Ins | novel | c.726_727insAAAG | p.Asp243LysfsTer8 | p.D243Kfs*8 | protein_coding | TCGA-D1-A102-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
NBPF9 | SNV | Missense_Mutation | novel | c.3259N>A | p.Val1087Met | p.V1087M | protein_coding | tolerated(0.25) | benign(0.075) | TCGA-5C-A9VG-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NBPF9 | SNV | Missense_Mutation | novel | c.89A>T | p.Glu30Val | p.E30V | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-DD-AADG-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
NBPF9 | SNV | Missense_Mutation | novel | c.1143N>C | p.Arg381Ser | p.R381S | protein_coding | tolerated(0.08) | benign(0.026) | TCGA-G3-A3CJ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
NBPF9 | SNV | Missense_Mutation | novel | c.1949C>G | p.Thr650Ser | p.T650S | protein_coding | tolerated(0.86) | possibly_damaging(0.535) | TCGA-ZS-A9CF-02 | Liver | NA | NA | NA | NA | NA | NA | NA | |
NBPF9 | SNV | Missense_Mutation | novel | c.508N>A | p.Glu170Lys | p.E170K | protein_coding | tolerated(0.05) | probably_damaging(0.979) | TCGA-55-A490-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | |
NBPF9 | SNV | Missense_Mutation | novel | c.1730N>T | p.Ser577Leu | p.S577L | protein_coding | tolerated(0.06) | benign(0.038) | TCGA-78-7150-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD | |
NBPF9 | SNV | Missense_Mutation | novel | c.1097N>G | p.Tyr366Cys | p.Y366C | protein_coding | tolerated(0.11) | benign(0.211) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD | |
NBPF9 | SNV | Missense_Mutation | novel | c.3114N>T | p.Glu1038Asp | p.E1038D | protein_coding | tolerated(0.22) | benign(0.048) | TCGA-95-A4VK-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |