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Gene: NBEAL1 |
Gene summary for NBEAL1 |
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Gene information | Species | Human | Gene symbol | NBEAL1 | Gene ID | 65065 |
Gene name | neurobeachin like 1 | |
Gene Alias | A530083I02Rik | |
Cytomap | 2q33.2 | |
Gene Type | protein-coding | GO ID | GO:0008104 | UniProtAcc | Q6ZS30 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65065 | NBEAL1 | GSM4909281 | Human | Breast | IDC | 3.59e-06 | 3.66e-01 | 0.21 |
65065 | NBEAL1 | GSM4909285 | Human | Breast | IDC | 7.37e-06 | -2.37e-01 | 0.21 |
65065 | NBEAL1 | GSM4909286 | Human | Breast | IDC | 7.05e-04 | -4.41e-02 | 0.1081 |
65065 | NBEAL1 | GSM4909287 | Human | Breast | IDC | 1.35e-14 | -4.45e-01 | 0.2057 |
65065 | NBEAL1 | GSM4909288 | Human | Breast | IDC | 2.86e-05 | -4.80e-01 | 0.0988 |
65065 | NBEAL1 | GSM4909293 | Human | Breast | IDC | 1.72e-06 | -2.40e-01 | 0.1581 |
65065 | NBEAL1 | GSM4909294 | Human | Breast | IDC | 3.03e-10 | -3.23e-01 | 0.2022 |
65065 | NBEAL1 | GSM4909296 | Human | Breast | IDC | 1.18e-15 | -3.67e-01 | 0.1524 |
65065 | NBEAL1 | GSM4909297 | Human | Breast | IDC | 4.68e-30 | 3.36e-01 | 0.1517 |
65065 | NBEAL1 | GSM4909299 | Human | Breast | IDC | 2.87e-06 | 4.31e-01 | 0.035 |
65065 | NBEAL1 | GSM4909301 | Human | Breast | IDC | 3.82e-03 | -2.13e-01 | 0.1577 |
65065 | NBEAL1 | GSM4909304 | Human | Breast | IDC | 1.14e-08 | -4.21e-01 | 0.1636 |
65065 | NBEAL1 | GSM4909309 | Human | Breast | IDC | 2.06e-05 | -2.88e-01 | 0.0483 |
65065 | NBEAL1 | GSM4909311 | Human | Breast | IDC | 2.69e-36 | -2.82e-01 | 0.1534 |
65065 | NBEAL1 | GSM4909312 | Human | Breast | IDC | 1.24e-23 | -4.90e-01 | 0.1552 |
65065 | NBEAL1 | GSM4909313 | Human | Breast | IDC | 1.27e-12 | -4.07e-01 | 0.0391 |
65065 | NBEAL1 | GSM4909316 | Human | Breast | IDC | 8.50e-03 | -4.01e-01 | 0.21 |
65065 | NBEAL1 | GSM4909317 | Human | Breast | IDC | 5.41e-06 | -3.38e-01 | 0.1355 |
65065 | NBEAL1 | GSM4909319 | Human | Breast | IDC | 1.34e-38 | -5.92e-01 | 0.1563 |
65065 | NBEAL1 | GSM4909320 | Human | Breast | IDC | 2.89e-09 | 8.71e-02 | 0.1575 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NBEAL1 | SNV | Missense_Mutation | novel | c.4028T>C | p.Leu1343Ser | p.L1343S | Q6ZS30 | protein_coding | tolerated(0.42) | benign(0.013) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NBEAL1 | SNV | Missense_Mutation | c.1442G>A | p.Arg481Gln | p.R481Q | Q6ZS30 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NBEAL1 | SNV | Missense_Mutation | novel | c.55N>T | p.Asp19Tyr | p.D19Y | Q6ZS30 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
NBEAL1 | SNV | Missense_Mutation | c.6181N>A | p.Leu2061Ile | p.L2061I | Q6ZS30 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
NBEAL1 | SNV | Missense_Mutation | c.577N>A | p.Glu193Lys | p.E193K | Q6ZS30 | protein_coding | deleterious(0) | benign(0.193) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NBEAL1 | SNV | Missense_Mutation | c.6597N>G | p.Ile2199Met | p.I2199M | Q6ZS30 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AD-6963-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NBEAL1 | SNV | Missense_Mutation | novel | c.6247N>G | p.Phe2083Val | p.F2083V | Q6ZS30 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NBEAL1 | SNV | Missense_Mutation | novel | c.7717N>A | p.Leu2573Met | p.L2573M | Q6ZS30 | protein_coding | deleterious(0) | possibly_damaging(0.776) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
NBEAL1 | SNV | Missense_Mutation | rs562005532 | c.7949N>C | p.Lys2650Thr | p.K2650T | Q6ZS30 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
NBEAL1 | SNV | Missense_Mutation | c.1847N>T | p.Arg616Met | p.R616M | Q6ZS30 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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