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Gene: MKL1 |
Gene summary for MKL1 |
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Gene information | Species | Human | Gene symbol | MKL1 | Gene ID | 57591 |
Gene name | myocardin related transcription factor A | |
Gene Alias | BSAC | |
Cytomap | 22q13.1-q13.2 | |
Gene Type | protein-coding | GO ID | GO:0002009 | UniProtAcc | A4FUJ8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57591 | MKL1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.26e-35 | -7.87e-01 | 0.0155 |
57591 | MKL1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.63e-21 | -7.87e-01 | -0.1808 |
57591 | MKL1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.56e-05 | -7.87e-01 | 0.0216 |
57591 | MKL1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.96e-16 | -7.87e-01 | -0.0811 |
57591 | MKL1 | HTA11_78_2000001011 | Human | Colorectum | AD | 7.21e-25 | -7.87e-01 | -0.1088 |
57591 | MKL1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.87e-37 | -7.87e-01 | -0.1954 |
57591 | MKL1 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.78e-03 | -7.87e-01 | -0.2602 |
57591 | MKL1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.06e-04 | -7.87e-01 | -0.2196 |
57591 | MKL1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.94e-17 | -7.87e-01 | -0.1207 |
57591 | MKL1 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.24e-14 | -7.87e-01 | -0.1526 |
57591 | MKL1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.49e-43 | -7.87e-01 | -0.1464 |
57591 | MKL1 | HTA11_866_2000001011 | Human | Colorectum | AD | 8.59e-39 | -7.87e-01 | -0.1001 |
57591 | MKL1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.13e-28 | -7.87e-01 | -0.059 |
57591 | MKL1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.15e-06 | -7.87e-01 | -0.1706 |
57591 | MKL1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 9.45e-08 | -7.87e-01 | -0.2061 |
57591 | MKL1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.56e-05 | -7.87e-01 | -0.1462 |
57591 | MKL1 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.90e-12 | -7.87e-01 | -0.0842 |
57591 | MKL1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.78e-03 | -7.87e-01 | -0.00410000000000005 |
57591 | MKL1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.45e-10 | -7.87e-01 | -0.0179 |
57591 | MKL1 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.25e-31 | -7.87e-01 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MKL1 | SNV | Missense_Mutation | rs766920620 | c.1312G>A | p.Ala438Thr | p.A438T | protein_coding | tolerated(1) | benign(0.046) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | |
MKL1 | SNV | Missense_Mutation | c.2860G>A | p.Asp954Asn | p.D954N | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
MKL1 | SNV | Missense_Mutation | rs750511313 | c.1318G>A | p.Glu440Lys | p.E440K | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
MKL1 | SNV | Missense_Mutation | c.196C>A | p.Arg66Ser | p.R66S | protein_coding | deleterious(0) | possibly_damaging(0.763) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
MKL1 | SNV | Missense_Mutation | novel | c.70N>T | p.Arg24Cys | p.R24C | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MKL1 | SNV | Missense_Mutation | rs373098603 | c.1355C>T | p.Thr452Met | p.T452M | protein_coding | deleterious(0) | possibly_damaging(0.65) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
MKL1 | SNV | Missense_Mutation | c.787G>A | p.Glu263Lys | p.E263K | protein_coding | deleterious(0) | probably_damaging(0.911) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MKL1 | SNV | Missense_Mutation | novel | c.934C>A | p.Gln312Lys | p.Q312K | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-D1-A2G5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
MKL1 | SNV | Missense_Mutation | novel | c.860C>T | p.Ala287Val | p.A287V | protein_coding | tolerated(0.34) | benign(0.018) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
MKL1 | SNV | Missense_Mutation | novel | c.2765N>A | p.Ser922Asn | p.S922N | protein_coding | tolerated(0.96) | benign(0.015) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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