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Gene: MFSD4B |
Gene summary for MFSD4B |
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Gene information | Species | Human | Gene symbol | MFSD4B | Gene ID | 91749 |
Gene name | major facilitator superfamily domain containing 4B | |
Gene Alias | KIAA1919 | |
Cytomap | 6q21 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | B3KSA1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91749 | MFSD4B | AEH-subject1 | Human | Endometrium | AEH | 4.35e-17 | 3.67e-01 | -0.3059 |
91749 | MFSD4B | AEH-subject2 | Human | Endometrium | AEH | 1.01e-10 | 2.76e-01 | -0.2525 |
91749 | MFSD4B | AEH-subject3 | Human | Endometrium | AEH | 1.30e-14 | 3.37e-01 | -0.2576 |
91749 | MFSD4B | AEH-subject4 | Human | Endometrium | AEH | 7.01e-29 | 6.53e-01 | -0.2657 |
91749 | MFSD4B | AEH-subject5 | Human | Endometrium | AEH | 1.26e-32 | 6.08e-01 | -0.2953 |
91749 | MFSD4B | EEC-subject1 | Human | Endometrium | EEC | 5.65e-20 | 4.10e-01 | -0.2682 |
91749 | MFSD4B | EEC-subject2 | Human | Endometrium | EEC | 1.78e-10 | 2.77e-01 | -0.2607 |
91749 | MFSD4B | EEC-subject3 | Human | Endometrium | EEC | 8.77e-08 | 2.31e-01 | -0.2525 |
91749 | MFSD4B | EEC-subject4 | Human | Endometrium | EEC | 1.60e-18 | 4.56e-01 | -0.2571 |
91749 | MFSD4B | EEC-subject5 | Human | Endometrium | EEC | 1.98e-24 | 4.88e-01 | -0.249 |
91749 | MFSD4B | GSM5276935 | Human | Endometrium | EEC | 3.51e-03 | 1.16e-01 | -0.123 |
91749 | MFSD4B | HCC1 | Human | Liver | HCC | 1.33e-13 | 3.09e+00 | 0.5336 |
91749 | MFSD4B | HCC2 | Human | Liver | HCC | 8.70e-29 | 3.45e+00 | 0.5341 |
91749 | MFSD4B | HCC5 | Human | Liver | HCC | 7.05e-15 | 1.90e+00 | 0.4932 |
91749 | MFSD4B | S014 | Human | Liver | HCC | 3.71e-02 | 1.77e-01 | 0.2254 |
91749 | MFSD4B | S015 | Human | Liver | HCC | 5.50e-06 | 2.87e-01 | 0.2375 |
91749 | MFSD4B | S016 | Human | Liver | HCC | 3.33e-08 | 2.62e-01 | 0.2243 |
91749 | MFSD4B | S028 | Human | Liver | HCC | 4.08e-04 | 2.50e-01 | 0.2503 |
91749 | MFSD4B | S029 | Human | Liver | HCC | 2.93e-07 | 2.77e-01 | 0.2581 |
91749 | MFSD4B | HTA12-23-1 | Human | Pancreas | PDAC | 5.60e-10 | 9.16e-01 | 0.3405 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008643 | Liver | HCC | carbohydrate transport | 80/7958 | 152/18723 | 7.34e-03 | 2.92e-02 | 80 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MFSD4B | deletion | Frame_Shift_Del | rs768729463 | c.596delN | p.Cys202ValfsTer4 | p.C202Vfs*4 | Q5TF39 | protein_coding | TCGA-AX-A3G9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | ||
MFSD4B | deletion | Frame_Shift_Del | rs768729463 | c.604delT | p.Cys202ValfsTer4 | p.C202Vfs*4 | Q5TF39 | protein_coding | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | ||
MFSD4B | deletion | Frame_Shift_Del | rs768729463 | c.596delN | p.Cys202ValfsTer4 | p.C202Vfs*4 | Q5TF39 | protein_coding | TCGA-BG-A2L7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | ||
MFSD4B | deletion | Frame_Shift_Del | rs768729463 | c.604delT | p.Cys202ValfsTer4 | p.C202Vfs*4 | Q5TF39 | protein_coding | TCGA-BK-A13B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
MFSD4B | deletion | Frame_Shift_Del | rs768729463 | c.596delN | p.Cys202ValfsTer4 | p.C202Vfs*4 | Q5TF39 | protein_coding | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | ||
MFSD4B | deletion | Frame_Shift_Del | rs768729463 | c.596delN | p.Cys202ValfsTer4 | p.C202Vfs*4 | Q5TF39 | protein_coding | TCGA-E6-A2P9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MFSD4B | deletion | Frame_Shift_Del | rs768729463 | c.596delN | p.Cys202ValfsTer4 | p.C202Vfs*4 | Q5TF39 | protein_coding | TCGA-EO-A3AZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MFSD4B | deletion | Frame_Shift_Del | rs768729463 | c.604delT | p.Cys202ValfsTer4 | p.C202Vfs*4 | Q5TF39 | protein_coding | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MFSD4B | deletion | Frame_Shift_Del | rs768729463 | c.596delN | p.Cys202ValfsTer4 | p.C202Vfs*4 | Q5TF39 | protein_coding | TCGA-EY-A1GK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MFSD4B | deletion | Frame_Shift_Del | rs768729463 | c.604delT | p.Cys202ValfsTer4 | p.C202Vfs*4 | Q5TF39 | protein_coding | TCGA-SL-A6JA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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