Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MFSD4B

Gene summary for MFSD4B

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MFSD4B

Gene ID

91749

Gene namemajor facilitator superfamily domain containing 4B
Gene AliasKIAA1919
Cytomap6q21
Gene Typeprotein-coding
GO ID

GO:0006810

UniProtAcc

B3KSA1


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
91749MFSD4BAEH-subject1HumanEndometriumAEH4.35e-173.67e-01-0.3059
91749MFSD4BAEH-subject2HumanEndometriumAEH1.01e-102.76e-01-0.2525
91749MFSD4BAEH-subject3HumanEndometriumAEH1.30e-143.37e-01-0.2576
91749MFSD4BAEH-subject4HumanEndometriumAEH7.01e-296.53e-01-0.2657
91749MFSD4BAEH-subject5HumanEndometriumAEH1.26e-326.08e-01-0.2953
91749MFSD4BEEC-subject1HumanEndometriumEEC5.65e-204.10e-01-0.2682
91749MFSD4BEEC-subject2HumanEndometriumEEC1.78e-102.77e-01-0.2607
91749MFSD4BEEC-subject3HumanEndometriumEEC8.77e-082.31e-01-0.2525
91749MFSD4BEEC-subject4HumanEndometriumEEC1.60e-184.56e-01-0.2571
91749MFSD4BEEC-subject5HumanEndometriumEEC1.98e-244.88e-01-0.249
91749MFSD4BGSM5276935HumanEndometriumEEC3.51e-031.16e-01-0.123
91749MFSD4BHCC1HumanLiverHCC1.33e-133.09e+000.5336
91749MFSD4BHCC2HumanLiverHCC8.70e-293.45e+000.5341
91749MFSD4BHCC5HumanLiverHCC7.05e-151.90e+000.4932
91749MFSD4BS014HumanLiverHCC3.71e-021.77e-010.2254
91749MFSD4BS015HumanLiverHCC5.50e-062.87e-010.2375
91749MFSD4BS016HumanLiverHCC3.33e-082.62e-010.2243
91749MFSD4BS028HumanLiverHCC4.08e-042.50e-010.2503
91749MFSD4BS029HumanLiverHCC2.93e-072.77e-010.2581
91749MFSD4BHTA12-23-1HumanPancreasPDAC5.60e-109.16e-010.3405
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0008643LiverHCCcarbohydrate transport80/7958152/187237.34e-032.92e-0280
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MFSD4BdeletionFrame_Shift_Delrs768729463c.596delNp.Cys202ValfsTer4p.C202Vfs*4Q5TF39protein_codingTCGA-AX-A3G9-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycarboplatinSD
MFSD4BdeletionFrame_Shift_Delrs768729463c.604delTp.Cys202ValfsTer4p.C202Vfs*4Q5TF39protein_codingTCGA-B5-A1MX-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIHormone TherapymegaceSD
MFSD4BdeletionFrame_Shift_Delrs768729463c.596delNp.Cys202ValfsTer4p.C202Vfs*4Q5TF39protein_codingTCGA-BG-A2L7-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIChemotherapycarboplatinCR
MFSD4BdeletionFrame_Shift_Delrs768729463c.604delTp.Cys202ValfsTer4p.C202Vfs*4Q5TF39protein_codingTCGA-BK-A13B-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownPD
MFSD4BdeletionFrame_Shift_Delrs768729463c.596delNp.Cys202ValfsTer4p.C202Vfs*4Q5TF39protein_codingTCGA-DI-A1BU-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIChemotherapypaclitaxelSD
MFSD4BdeletionFrame_Shift_Delrs768729463c.596delNp.Cys202ValfsTer4p.C202Vfs*4Q5TF39protein_codingTCGA-E6-A2P9-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
MFSD4BdeletionFrame_Shift_Delrs768729463c.596delNp.Cys202ValfsTer4p.C202Vfs*4Q5TF39protein_codingTCGA-EO-A3AZ-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
MFSD4BdeletionFrame_Shift_Delrs768729463c.604delTp.Cys202ValfsTer4p.C202Vfs*4Q5TF39protein_codingTCGA-EO-A3KX-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
MFSD4BdeletionFrame_Shift_Delrs768729463c.596delNp.Cys202ValfsTer4p.C202Vfs*4Q5TF39protein_codingTCGA-EY-A1GK-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
MFSD4BdeletionFrame_Shift_Delrs768729463c.604delTp.Cys202ValfsTer4p.C202Vfs*4Q5TF39protein_codingTCGA-SL-A6JA-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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