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Gene: METTL6 |
Gene summary for METTL6 |
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Gene information | Species | Human | Gene symbol | METTL6 | Gene ID | 131965 |
Gene name | methyltransferase 6, methylcytidine | |
Gene Alias | METTL6 | |
Cytomap | 3p25.1 | |
Gene Type | protein-coding | GO ID | GO:0001510 | UniProtAcc | B4DDX3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
131965 | METTL6 | LZE4T | Human | Esophagus | ESCC | 1.21e-05 | 1.56e-01 | 0.0811 |
131965 | METTL6 | LZE24T | Human | Esophagus | ESCC | 1.41e-03 | 1.48e-01 | 0.0596 |
131965 | METTL6 | P2T-E | Human | Esophagus | ESCC | 4.54e-07 | 1.40e-01 | 0.1177 |
131965 | METTL6 | P4T-E | Human | Esophagus | ESCC | 3.45e-14 | 3.61e-01 | 0.1323 |
131965 | METTL6 | P5T-E | Human | Esophagus | ESCC | 9.26e-16 | 3.69e-01 | 0.1327 |
131965 | METTL6 | P8T-E | Human | Esophagus | ESCC | 1.42e-06 | 1.14e-01 | 0.0889 |
131965 | METTL6 | P9T-E | Human | Esophagus | ESCC | 1.82e-02 | 1.06e-01 | 0.1131 |
131965 | METTL6 | P10T-E | Human | Esophagus | ESCC | 2.05e-21 | 3.43e-01 | 0.116 |
131965 | METTL6 | P11T-E | Human | Esophagus | ESCC | 4.33e-02 | 1.71e-01 | 0.1426 |
131965 | METTL6 | P12T-E | Human | Esophagus | ESCC | 7.52e-17 | 1.45e-01 | 0.1122 |
131965 | METTL6 | P15T-E | Human | Esophagus | ESCC | 5.55e-03 | 1.10e-01 | 0.1149 |
131965 | METTL6 | P16T-E | Human | Esophagus | ESCC | 5.01e-10 | 2.30e-01 | 0.1153 |
131965 | METTL6 | P19T-E | Human | Esophagus | ESCC | 3.74e-02 | 2.13e-01 | 0.1662 |
131965 | METTL6 | P20T-E | Human | Esophagus | ESCC | 1.73e-05 | 1.66e-01 | 0.1124 |
131965 | METTL6 | P21T-E | Human | Esophagus | ESCC | 2.21e-12 | 2.22e-01 | 0.1617 |
131965 | METTL6 | P22T-E | Human | Esophagus | ESCC | 6.01e-05 | 1.20e-01 | 0.1236 |
131965 | METTL6 | P23T-E | Human | Esophagus | ESCC | 1.12e-06 | 2.26e-01 | 0.108 |
131965 | METTL6 | P24T-E | Human | Esophagus | ESCC | 1.15e-07 | 1.74e-01 | 0.1287 |
131965 | METTL6 | P26T-E | Human | Esophagus | ESCC | 1.34e-07 | 1.93e-01 | 0.1276 |
131965 | METTL6 | P27T-E | Human | Esophagus | ESCC | 1.69e-08 | 1.37e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00015101 | Esophagus | ESCC | RNA methylation | 58/8552 | 83/18723 | 6.87e-06 | 6.94e-05 | 58 |
GO:00064002 | Esophagus | ESCC | tRNA modification | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:00304881 | Esophagus | ESCC | tRNA methylation | 30/8552 | 41/18723 | 3.27e-04 | 1.93e-03 | 30 |
GO:00344704 | Liver | NAFLD | ncRNA processing | 57/1882 | 395/18723 | 3.34e-03 | 2.93e-02 | 57 |
GO:0043414 | Liver | NAFLD | macromolecule methylation | 47/1882 | 316/18723 | 4.08e-03 | 3.41e-02 | 47 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:0008033 | Liver | HCC | tRNA processing | 87/7958 | 127/18723 | 2.66e-09 | 7.23e-08 | 87 |
GO:00434141 | Liver | HCC | macromolecule methylation | 183/7958 | 316/18723 | 2.00e-08 | 4.72e-07 | 183 |
GO:0032259 | Liver | HCC | methylation | 206/7958 | 364/18723 | 3.35e-08 | 7.53e-07 | 206 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:0009451 | Liver | HCC | RNA modification | 101/7958 | 167/18723 | 2.02e-06 | 2.78e-05 | 101 |
GO:0006400 | Liver | HCC | tRNA modification | 60/7958 | 90/18723 | 3.09e-06 | 4.09e-05 | 60 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
METTL6 | insertion | Frame_Shift_Ins | novel | c.145_146insT | p.Tyr49LeufsTer5 | p.Y49Lfs*5 | Q8TCB7 | protein_coding | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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