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Gene: MCM10 |
Gene summary for MCM10 |
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Gene information | Species | Human | Gene symbol | MCM10 | Gene ID | 55388 |
Gene name | minichromosome maintenance 10 replication initiation factor | |
Gene Alias | CNA43 | |
Cytomap | 10p13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q7L590 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55388 | MCM10 | P2T-E | Human | Esophagus | ESCC | 7.94e-07 | 2.26e-01 | 0.1177 |
55388 | MCM10 | P4T-E | Human | Esophagus | ESCC | 8.00e-03 | 1.26e-01 | 0.1323 |
55388 | MCM10 | P5T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.72e-01 | 0.1327 |
55388 | MCM10 | P16T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.30e-01 | 0.1153 |
55388 | MCM10 | P21T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.38e-01 | 0.1617 |
55388 | MCM10 | P24T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.85e-01 | 0.1287 |
55388 | MCM10 | P31T-E | Human | Esophagus | ESCC | 9.44e-07 | 2.11e-01 | 0.1251 |
55388 | MCM10 | P32T-E | Human | Esophagus | ESCC | 4.41e-07 | 1.74e-01 | 0.1666 |
55388 | MCM10 | P37T-E | Human | Esophagus | ESCC | 4.27e-06 | 2.10e-01 | 0.1371 |
55388 | MCM10 | P52T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.50e-01 | 0.1555 |
55388 | MCM10 | P76T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.21e-01 | 0.1207 |
55388 | MCM10 | P79T-E | Human | Esophagus | ESCC | 1.96e-05 | 2.15e-01 | 0.1154 |
55388 | MCM10 | P83T-E | Human | Esophagus | ESCC | 3.53e-13 | 6.07e-01 | 0.1738 |
55388 | MCM10 | P91T-E | Human | Esophagus | ESCC | 5.34e-06 | 6.81e-01 | 0.1828 |
55388 | MCM10 | P107T-E | Human | Esophagus | ESCC | 8.98e-03 | 1.18e-01 | 0.171 |
55388 | MCM10 | P130T-E | Human | Esophagus | ESCC | 3.89e-12 | 4.56e-01 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:00062612 | Esophagus | ESCC | DNA-dependent DNA replication | 100/8552 | 151/18723 | 2.61e-07 | 3.94e-06 | 100 |
GO:00062701 | Esophagus | ESCC | DNA replication initiation | 27/8552 | 34/18723 | 6.01e-05 | 4.62e-04 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MCM10 | SNV | Missense_Mutation | novel | c.2114N>A | p.Ser705Tyr | p.S705Y | Q7L590 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
MCM10 | SNV | Missense_Mutation | novel | c.1043G>A | p.Gly348Glu | p.G348E | Q7L590 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
MCM10 | SNV | Missense_Mutation | c.1826G>A | p.Arg609Gln | p.R609Q | Q7L590 | protein_coding | tolerated(0.38) | benign(0.003) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
MCM10 | SNV | Missense_Mutation | rs754749477 | c.1837N>A | p.Glu613Lys | p.E613K | Q7L590 | protein_coding | tolerated(0.09) | benign(0.072) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MCM10 | SNV | Missense_Mutation | rs373990822 | c.1703G>A | p.Arg568Gln | p.R568Q | Q7L590 | protein_coding | tolerated(1) | benign(0) | TCGA-AX-A1C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MCM10 | SNV | Missense_Mutation | novel | c.2224N>G | p.Thr742Ala | p.T742A | Q7L590 | protein_coding | tolerated(0.22) | benign(0.284) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
MCM10 | SNV | Missense_Mutation | c.554N>T | p.Arg185Ile | p.R185I | Q7L590 | protein_coding | tolerated(0.07) | benign(0.03) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
MCM10 | SNV | Missense_Mutation | rs769266273 | c.1034C>T | p.Thr345Met | p.T345M | Q7L590 | protein_coding | tolerated(0.09) | probably_damaging(0.997) | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MCM10 | SNV | Missense_Mutation | novel | c.1789N>T | p.Pro597Ser | p.P597S | Q7L590 | protein_coding | tolerated(0.15) | benign(0.077) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MCM10 | SNV | Missense_Mutation | c.599N>T | p.Pro200Leu | p.P200L | Q7L590 | protein_coding | tolerated(0.21) | benign(0.015) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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