GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00072495 | Lung | IAC | I-kappaB kinase/NF-kappaB signaling | 56/2061 | 281/18723 | 7.39e-06 | 2.62e-04 | 56 |
GO:00431226 | Lung | IAC | regulation of I-kappaB kinase/NF-kappaB signaling | 51/2061 | 249/18723 | 8.41e-06 | 2.87e-04 | 51 |
GO:00714968 | Lung | IAC | cellular response to external stimulus | 60/2061 | 320/18723 | 2.50e-05 | 6.76e-04 | 60 |
GO:00431235 | Lung | IAC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 38/2061 | 186/18723 | 1.19e-04 | 2.25e-03 | 38 |
GO:00712146 | Lung | IAC | cellular response to abiotic stimulus | 58/2061 | 331/18723 | 2.30e-04 | 3.96e-03 | 58 |
GO:01040046 | Lung | IAC | cellular response to environmental stimulus | 58/2061 | 331/18723 | 2.30e-04 | 3.96e-03 | 58 |
GO:00096156 | Lung | IAC | response to virus | 61/2061 | 367/18723 | 6.75e-04 | 9.12e-03 | 61 |
GO:00096125 | Lung | IAC | response to mechanical stimulus | 39/2061 | 216/18723 | 1.29e-03 | 1.45e-02 | 39 |
GO:000961515 | Oral cavity | OSCC | response to virus | 215/7305 | 367/18723 | 1.63e-14 | 9.41e-13 | 215 |
GO:004312218 | Oral cavity | OSCC | regulation of I-kappaB kinase/NF-kappaB signaling | 155/7305 | 249/18723 | 7.79e-14 | 4.14e-12 | 155 |
GO:004312310 | Oral cavity | OSCC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 122/7305 | 186/18723 | 1.68e-13 | 8.52e-12 | 122 |
GO:000724910 | Oral cavity | OSCC | I-kappaB kinase/NF-kappaB signaling | 169/7305 | 281/18723 | 4.69e-13 | 2.25e-11 | 169 |
GO:007149620 | Oral cavity | OSCC | cellular response to external stimulus | 186/7305 | 320/18723 | 2.56e-12 | 1.05e-10 | 186 |
GO:007121416 | Oral cavity | OSCC | cellular response to abiotic stimulus | 186/7305 | 331/18723 | 1.38e-10 | 4.10e-09 | 186 |
GO:010400416 | Oral cavity | OSCC | cellular response to environmental stimulus | 186/7305 | 331/18723 | 1.38e-10 | 4.10e-09 | 186 |
GO:00516074 | Oral cavity | OSCC | defense response to virus | 154/7305 | 265/18723 | 1.96e-10 | 5.63e-09 | 154 |
GO:01405464 | Oral cavity | OSCC | defense response to symbiont | 154/7305 | 265/18723 | 1.96e-10 | 5.63e-09 | 154 |
GO:00712605 | Oral cavity | OSCC | cellular response to mechanical stimulus | 52/7305 | 81/18723 | 3.86e-06 | 4.55e-05 | 52 |
GO:000961210 | Oral cavity | OSCC | response to mechanical stimulus | 115/7305 | 216/18723 | 1.43e-05 | 1.44e-04 | 115 |
GO:00380614 | Oral cavity | OSCC | NIK/NF-kappaB signaling | 78/7305 | 143/18723 | 1.14e-04 | 8.35e-04 | 78 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520816 | Lung | IAC | Chemical carcinogenesis - reactive oxygen species | 51/1053 | 223/8465 | 8.45e-06 | 2.14e-04 | 1.42e-04 | 51 |
hsa0516616 | Lung | IAC | Human T-cell leukemia virus 1 infection | 49/1053 | 222/8465 | 3.44e-05 | 6.38e-04 | 4.24e-04 | 49 |
hsa040108 | Lung | IAC | MAPK signaling pathway | 62/1053 | 302/8465 | 3.54e-05 | 6.38e-04 | 4.24e-04 | 62 |
hsa051205 | Lung | IAC | Epithelial cell signaling in Helicobacter pylori infection | 20/1053 | 70/8465 | 2.31e-04 | 2.54e-03 | 1.68e-03 | 20 |
hsa04625 | Lung | IAC | C-type lectin receptor signaling pathway | 26/1053 | 104/8465 | 3.15e-04 | 3.11e-03 | 2.06e-03 | 26 |
hsa042107 | Lung | IAC | Apoptosis | 30/1053 | 136/8465 | 1.11e-03 | 7.82e-03 | 5.19e-03 | 30 |
hsa0516916 | Lung | IAC | Epstein-Barr virus infection | 40/1053 | 202/8465 | 1.72e-03 | 9.66e-03 | 6.41e-03 | 40 |
hsa046685 | Lung | IAC | TNF signaling pathway | 25/1053 | 114/8465 | 3.01e-03 | 1.53e-02 | 1.02e-02 | 25 |
hsa04380 | Lung | IAC | Osteoclast differentiation | 27/1053 | 128/8465 | 3.74e-03 | 1.84e-02 | 1.22e-02 | 27 |
hsa04660 | Lung | IAC | T cell receptor signaling pathway | 23/1053 | 104/8465 | 3.88e-03 | 1.88e-02 | 1.25e-02 | 23 |
hsa049364 | Lung | IAC | Alcoholic liver disease | 29/1053 | 142/8465 | 4.45e-03 | 2.07e-02 | 1.37e-02 | 29 |
hsa0520817 | Lung | IAC | Chemical carcinogenesis - reactive oxygen species | 51/1053 | 223/8465 | 8.45e-06 | 2.14e-04 | 1.42e-04 | 51 |
hsa0516617 | Lung | IAC | Human T-cell leukemia virus 1 infection | 49/1053 | 222/8465 | 3.44e-05 | 6.38e-04 | 4.24e-04 | 49 |
hsa0401011 | Lung | IAC | MAPK signaling pathway | 62/1053 | 302/8465 | 3.54e-05 | 6.38e-04 | 4.24e-04 | 62 |
hsa0512012 | Lung | IAC | Epithelial cell signaling in Helicobacter pylori infection | 20/1053 | 70/8465 | 2.31e-04 | 2.54e-03 | 1.68e-03 | 20 |
hsa046251 | Lung | IAC | C-type lectin receptor signaling pathway | 26/1053 | 104/8465 | 3.15e-04 | 3.11e-03 | 2.06e-03 | 26 |
hsa0421012 | Lung | IAC | Apoptosis | 30/1053 | 136/8465 | 1.11e-03 | 7.82e-03 | 5.19e-03 | 30 |
hsa0516917 | Lung | IAC | Epstein-Barr virus infection | 40/1053 | 202/8465 | 1.72e-03 | 9.66e-03 | 6.41e-03 | 40 |
hsa0466812 | Lung | IAC | TNF signaling pathway | 25/1053 | 114/8465 | 3.01e-03 | 1.53e-02 | 1.02e-02 | 25 |
hsa043801 | Lung | IAC | Osteoclast differentiation | 27/1053 | 128/8465 | 3.74e-03 | 1.84e-02 | 1.22e-02 | 27 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAP3K14 | SNV | Missense_Mutation | novel | c.1279N>A | p.Ala427Thr | p.A427T | Q99558 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-BG-A2L7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
MAP3K14 | SNV | Missense_Mutation | novel | c.1364T>C | p.Leu455Ser | p.L455S | Q99558 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAP3K14 | SNV | Missense_Mutation | novel | c.850N>A | p.Leu284Met | p.L284M | Q99558 | protein_coding | deleterious(0.01) | possibly_damaging(0.797) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
MAP3K14 | SNV | Missense_Mutation | novel | c.1853N>A | p.Ile618Asn | p.I618N | Q99558 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EC-A24G-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
MAP3K14 | SNV | Missense_Mutation | novel | c.2600N>A | p.Ser867Tyr | p.S867Y | Q99558 | protein_coding | tolerated(0.08) | possibly_damaging(0.687) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAP3K14 | SNV | Missense_Mutation | rs766888695 | c.412N>T | p.Arg138Cys | p.R138C | Q99558 | protein_coding | deleterious(0.03) | possibly_damaging(0.451) | TCGA-SJ-A6ZI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAP3K14 | deletion | Frame_Shift_Del | novel | c.438delG | p.Lys147ArgfsTer54 | p.K147Rfs*54 | Q99558 | protein_coding | | | TCGA-A5-AB3J-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
MAP3K14 | deletion | In_Frame_Del | novel | c.2335_2337delCTC | p.Leu779del | p.L779del | Q99558 | protein_coding | | | TCGA-D1-A176-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAP3K14 | SNV | Missense_Mutation | novel | c.295N>G | p.Arg99Gly | p.R99G | Q99558 | protein_coding | deleterious(0) | possibly_damaging(0.873) | TCGA-CC-A7IF-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
MAP3K14 | SNV | Missense_Mutation | novel | c.139N>G | p.Lys47Glu | p.K47E | Q99558 | protein_coding | deleterious_low_confidence(0.01) | benign(0.115) | TCGA-DD-A118-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9020 | MAP3K14 | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE | inhibitor | 374883851 | | |
9020 | MAP3K14 | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE | inhibitor | 374883852 | | |
9020 | MAP3K14 | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE | inhibitor | 249565854 | | |
9020 | MAP3K14 | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE | inhibitor | 405560388 | | |