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Gene: MAGEA1 |
Gene summary for MAGEA1 |
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Gene information | Species | Human | Gene symbol | MAGEA1 | Gene ID | 4100 |
Gene name | MAGE family member A1 | |
Gene Alias | CT1.1 | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P43355 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4100 | MAGEA1 | LZE2T | Human | Esophagus | ESCC | 5.44e-10 | 8.56e-01 | 0.082 |
4100 | MAGEA1 | LZE4T | Human | Esophagus | ESCC | 1.70e-03 | 1.31e-01 | 0.0811 |
4100 | MAGEA1 | LZE7T | Human | Esophagus | ESCC | 2.68e-16 | 8.80e-01 | 0.0667 |
4100 | MAGEA1 | HCC1_Meng | Human | Liver | HCC | 4.33e-03 | 1.91e-02 | 0.0246 |
4100 | MAGEA1 | HCC2 | Human | Liver | HCC | 2.50e-06 | 1.05e+00 | 0.5341 |
4100 | MAGEA1 | S014 | Human | Liver | HCC | 2.45e-28 | 7.74e-01 | 0.2254 |
4100 | MAGEA1 | S015 | Human | Liver | HCC | 3.77e-10 | 5.96e-01 | 0.2375 |
4100 | MAGEA1 | S016 | Human | Liver | HCC | 9.85e-26 | 7.68e-01 | 0.2243 |
4100 | MAGEA1 | C30 | Human | Oral cavity | OSCC | 4.65e-50 | 1.88e+00 | 0.3055 |
4100 | MAGEA1 | C43 | Human | Oral cavity | OSCC | 3.76e-70 | 1.20e+00 | 0.1704 |
4100 | MAGEA1 | C08 | Human | Oral cavity | OSCC | 9.26e-07 | 2.63e-01 | 0.1919 |
4100 | MAGEA1 | SYSMH1 | Human | Oral cavity | OSCC | 6.15e-15 | 3.08e-01 | 0.1127 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00072197 | Esophagus | ESCC | Notch signaling pathway | 106/8552 | 172/18723 | 1.74e-05 | 1.55e-04 | 106 |
GO:0045746 | Esophagus | ESCC | negative regulation of Notch signaling pathway | 28/8552 | 36/18723 | 8.62e-05 | 6.22e-04 | 28 |
GO:00085935 | Esophagus | ESCC | regulation of Notch signaling pathway | 59/8552 | 95/18723 | 9.12e-04 | 4.65e-03 | 59 |
GO:00072196 | Oral cavity | OSCC | Notch signaling pathway | 92/7305 | 172/18723 | 7.84e-05 | 6.08e-04 | 92 |
GO:00085934 | Oral cavity | OSCC | regulation of Notch signaling pathway | 53/7305 | 95/18723 | 6.64e-04 | 3.72e-03 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAGEA1 | SNV | Missense_Mutation | novel | c.419N>C | p.Phe140Ser | p.F140S | P43355 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-L3-A524-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MAGEA1 | SNV | Missense_Mutation | novel | c.814N>A | p.Ala272Thr | p.A272T | P43355 | protein_coding | deleterious(0.02) | benign(0.005) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
MAGEA1 | SNV | Missense_Mutation | c.135N>T | p.Glu45Asp | p.E45D | P43355 | protein_coding | tolerated(0.21) | benign(0.211) | TCGA-HU-A4H3-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | ts-1 | PD | |
MAGEA1 | SNV | Missense_Mutation | novel | c.484G>T | p.Ala162Ser | p.A162S | P43355 | protein_coding | deleterious(0.01) | benign(0.396) | TCGA-IN-A7NT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | leucovorin | SD |
MAGEA1 | SNV | Missense_Mutation | novel | c.208N>G | p.Phe70Val | p.F70V | P43355 | protein_coding | tolerated(0.35) | benign(0.173) | TCGA-VQ-A8P5-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | fluorouracil | SD |
MAGEA1 | SNV | Missense_Mutation | c.898N>A | p.Ala300Thr | p.A300T | P43355 | protein_coding | deleterious(0.01) | benign(0.03) | TCGA-ET-A3DO-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4100 | MAGEA1 | NA | ARA-C | 8749237 | ||
4100 | MAGEA1 | NA | 5-AZA-2-DEOXYCYTIDINE | 9247253 | ||
4100 | MAGEA1 | NA | 5-AZA-2&APOS;-DEOXYCYTIDINE | 8757382,15256472,7511051,8698626 | ||
4100 | MAGEA1 | NA | CAR-T cells targeting MAGE-A1 |
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