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Gene: LRRC8B |
Gene summary for LRRC8B |
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Gene information | Species | Human | Gene symbol | LRRC8B | Gene ID | 23507 |
Gene name | leucine rich repeat containing 8 VRAC subunit B | |
Gene Alias | TA-LRRP | |
Cytomap | 1p22.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q6P9F7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23507 | LRRC8B | LZE4T | Human | Esophagus | ESCC | 1.06e-04 | 9.98e-02 | 0.0811 |
23507 | LRRC8B | LZE22T | Human | Esophagus | ESCC | 2.26e-02 | 1.50e-01 | 0.068 |
23507 | LRRC8B | LZE24T | Human | Esophagus | ESCC | 3.69e-05 | 1.33e-01 | 0.0596 |
23507 | LRRC8B | P2T-E | Human | Esophagus | ESCC | 8.02e-12 | 1.62e-01 | 0.1177 |
23507 | LRRC8B | P4T-E | Human | Esophagus | ESCC | 5.49e-09 | 1.37e-01 | 0.1323 |
23507 | LRRC8B | P5T-E | Human | Esophagus | ESCC | 1.47e-06 | 1.31e-01 | 0.1327 |
23507 | LRRC8B | P8T-E | Human | Esophagus | ESCC | 1.48e-05 | 6.48e-02 | 0.0889 |
23507 | LRRC8B | P9T-E | Human | Esophagus | ESCC | 4.29e-03 | 1.23e-01 | 0.1131 |
23507 | LRRC8B | P10T-E | Human | Esophagus | ESCC | 7.40e-06 | 9.31e-02 | 0.116 |
23507 | LRRC8B | P11T-E | Human | Esophagus | ESCC | 6.57e-03 | 7.42e-02 | 0.1426 |
23507 | LRRC8B | P12T-E | Human | Esophagus | ESCC | 1.02e-65 | 1.29e+00 | 0.1122 |
23507 | LRRC8B | P15T-E | Human | Esophagus | ESCC | 1.63e-11 | 2.22e-01 | 0.1149 |
23507 | LRRC8B | P16T-E | Human | Esophagus | ESCC | 2.83e-05 | 1.35e-02 | 0.1153 |
23507 | LRRC8B | P20T-E | Human | Esophagus | ESCC | 1.71e-07 | 1.30e-01 | 0.1124 |
23507 | LRRC8B | P22T-E | Human | Esophagus | ESCC | 1.97e-02 | -1.84e-02 | 0.1236 |
23507 | LRRC8B | P23T-E | Human | Esophagus | ESCC | 1.54e-15 | 2.83e-01 | 0.108 |
23507 | LRRC8B | P24T-E | Human | Esophagus | ESCC | 1.62e-04 | 1.95e-02 | 0.1287 |
23507 | LRRC8B | P26T-E | Human | Esophagus | ESCC | 5.87e-12 | 3.10e-01 | 0.1276 |
23507 | LRRC8B | P27T-E | Human | Esophagus | ESCC | 2.82e-06 | 1.13e-01 | 0.1055 |
23507 | LRRC8B | P28T-E | Human | Esophagus | ESCC | 3.15e-11 | 1.87e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRRC8B | SNV | Missense_Mutation | novel | c.1175G>A | p.Ser392Asn | p.S392N | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-EO-A3AU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
LRRC8B | SNV | Missense_Mutation | novel | c.16N>C | p.Glu6Gln | p.E6Q | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EY-A1GS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD | |
LRRC8B | insertion | In_Frame_Ins | novel | c.1348_1349insAAGATT | p.Ile450delinsLysAspPhe | p.I450delinsKDF | protein_coding | TCGA-A5-A0R7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
LRRC8B | insertion | Nonsense_Mutation | novel | c.1208_1209insATGATGTCCT | p.Asn403LysfsTer2 | p.N403Kfs*2 | protein_coding | TCGA-A5-A0R8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
LRRC8B | insertion | In_Frame_Ins | novel | c.1348_1349insAAGATT | p.Ile450delinsLysAspPhe | p.I450delinsKDF | protein_coding | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |||
LRRC8B | insertion | Frame_Shift_Ins | novel | c.1348_1349insAAGAT | p.Ile450LysfsTer6 | p.I450Kfs*6 | protein_coding | TCGA-BG-A0MU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Hormone Therapy | megace | SD | |||
LRRC8B | insertion | Frame_Shift_Ins | novel | c.1348_1349insAAGAT | p.Ile450LysfsTer6 | p.I450Kfs*6 | protein_coding | TCGA-D1-A102-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
LRRC8B | SNV | Missense_Mutation | c.1990N>T | p.Asp664Tyr | p.D664Y | protein_coding | deleterious(0) | benign(0.091) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
LRRC8B | SNV | Missense_Mutation | c.2273N>G | p.Asn758Ser | p.N758S | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-50-5939-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
LRRC8B | SNV | Missense_Mutation | novel | c.1348N>T | p.Ile450Phe | p.I450F | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-55-7913-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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