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Gene: LONRF2 |
Gene summary for LONRF2 |
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Gene information | Species | Human | Gene symbol | LONRF2 | Gene ID | 164832 |
Gene name | LON peptidase N-terminal domain and ring finger 2 | |
Gene Alias | RNF192 | |
Cytomap | 2q11.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q1L5Z9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
164832 | LONRF2 | HTA12-15-2 | Human | Pancreas | PDAC | 5.50e-06 | 5.71e-01 | 0.2315 |
164832 | LONRF2 | HTA12-23-1 | Human | Pancreas | PDAC | 1.72e-06 | 8.41e-01 | 0.3405 |
164832 | LONRF2 | HTA12-25-1 | Human | Pancreas | PDAC | 3.32e-03 | 5.46e-01 | 0.313 |
164832 | LONRF2 | HTA12-26-1 | Human | Pancreas | PDAC | 4.09e-29 | 1.19e+00 | 0.3728 |
164832 | LONRF2 | HTA12-29-1 | Human | Pancreas | PDAC | 5.66e-47 | 1.04e+00 | 0.3722 |
164832 | LONRF2 | PTCwithHT_8 | Human | Thyroid | HT | 1.09e-02 | -1.33e-01 | 0.0351 |
164832 | LONRF2 | male-WTA | Human | Thyroid | PTC | 9.44e-39 | 4.65e-01 | 0.1037 |
164832 | LONRF2 | PTC01 | Human | Thyroid | PTC | 1.29e-31 | 1.15e+00 | 0.1899 |
164832 | LONRF2 | PTC03 | Human | Thyroid | PTC | 3.69e-06 | 5.88e-01 | 0.1784 |
164832 | LONRF2 | PTC04 | Human | Thyroid | PTC | 4.52e-38 | 1.10e+00 | 0.1927 |
164832 | LONRF2 | PTC05 | Human | Thyroid | PTC | 1.17e-33 | 1.83e+00 | 0.2065 |
164832 | LONRF2 | PTC06 | Human | Thyroid | PTC | 1.34e-82 | 2.56e+00 | 0.2057 |
164832 | LONRF2 | PTC07 | Human | Thyroid | PTC | 1.24e-85 | 2.02e+00 | 0.2044 |
164832 | LONRF2 | ATC12 | Human | Thyroid | ATC | 1.09e-02 | -1.39e-01 | 0.34 |
164832 | LONRF2 | ATC13 | Human | Thyroid | ATC | 6.23e-21 | 1.54e-01 | 0.34 |
164832 | LONRF2 | ATC5 | Human | Thyroid | ATC | 6.69e-15 | 1.67e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LONRF2 | SNV | Missense_Mutation | rs373744289 | c.1724N>A | p.Arg575Gln | p.R575Q | Q1L5Z9 | protein_coding | tolerated(1) | benign(0.038) | TCGA-EY-A549-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LONRF2 | SNV | Missense_Mutation | novel | c.1759N>G | p.Leu587Val | p.L587V | Q1L5Z9 | protein_coding | deleterious(0.01) | benign(0.062) | TCGA-55-7576-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | alimta | CR |
LONRF2 | SNV | Missense_Mutation | c.1180N>T | p.Ala394Ser | p.A394S | Q1L5Z9 | protein_coding | tolerated(0.65) | benign(0.029) | TCGA-55-8085-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
LONRF2 | SNV | Missense_Mutation | rs779900474 | c.874N>T | p.Leu292Phe | p.L292F | Q1L5Z9 | protein_coding | deleterious(0.03) | probably_damaging(0.964) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LONRF2 | SNV | Missense_Mutation | c.1775G>A | p.Cys592Tyr | p.C592Y | Q1L5Z9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-22-4591-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | gemzar | PD | |
LONRF2 | SNV | Missense_Mutation | c.1729N>T | p.Gly577Cys | p.G577C | Q1L5Z9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-33-4566-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
LONRF2 | SNV | Missense_Mutation | novel | c.1192N>A | p.Gly398Ser | p.G398S | Q1L5Z9 | protein_coding | tolerated(0.38) | benign(0.009) | TCGA-56-8305-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
LONRF2 | SNV | Missense_Mutation | novel | c.1126C>G | p.Leu376Val | p.L376V | Q1L5Z9 | protein_coding | tolerated(0.22) | benign(0.131) | TCGA-96-7545-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
LONRF2 | SNV | Missense_Mutation | rs777776322 | c.893N>A | p.Cys298Tyr | p.C298Y | Q1L5Z9 | protein_coding | tolerated(1) | benign(0.017) | TCGA-CN-6018-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LONRF2 | SNV | Missense_Mutation | rs373744289 | c.1724N>A | p.Arg575Gln | p.R575Q | Q1L5Z9 | protein_coding | tolerated(1) | benign(0.038) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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