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Gene: LMLN |
Gene summary for LMLN |
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Gene information | Species | Human | Gene symbol | LMLN | Gene ID | 89782 |
Gene name | leishmanolysin like peptidase | |
Gene Alias | GP63 | |
Cytomap | 3q29 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | B4DR62 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
89782 | LMLN | LZE2T | Human | Esophagus | ESCC | 4.79e-02 | 2.90e-01 | 0.082 |
89782 | LMLN | LZE24T | Human | Esophagus | ESCC | 3.83e-02 | 1.46e-01 | 0.0596 |
89782 | LMLN | P2T-E | Human | Esophagus | ESCC | 7.92e-27 | 4.24e-01 | 0.1177 |
89782 | LMLN | P4T-E | Human | Esophagus | ESCC | 4.54e-05 | 1.91e-01 | 0.1323 |
89782 | LMLN | P8T-E | Human | Esophagus | ESCC | 4.41e-02 | 9.46e-02 | 0.0889 |
89782 | LMLN | P10T-E | Human | Esophagus | ESCC | 3.23e-09 | 2.06e-01 | 0.116 |
89782 | LMLN | P11T-E | Human | Esophagus | ESCC | 7.73e-03 | 2.19e-01 | 0.1426 |
89782 | LMLN | P15T-E | Human | Esophagus | ESCC | 7.52e-04 | 9.28e-02 | 0.1149 |
89782 | LMLN | P16T-E | Human | Esophagus | ESCC | 1.40e-12 | 2.43e-01 | 0.1153 |
89782 | LMLN | P20T-E | Human | Esophagus | ESCC | 1.94e-02 | 9.62e-02 | 0.1124 |
89782 | LMLN | P21T-E | Human | Esophagus | ESCC | 5.21e-05 | 9.28e-02 | 0.1617 |
89782 | LMLN | P22T-E | Human | Esophagus | ESCC | 2.36e-07 | 1.55e-01 | 0.1236 |
89782 | LMLN | P23T-E | Human | Esophagus | ESCC | 8.34e-04 | 1.08e-01 | 0.108 |
89782 | LMLN | P24T-E | Human | Esophagus | ESCC | 7.08e-03 | 7.40e-02 | 0.1287 |
89782 | LMLN | P27T-E | Human | Esophagus | ESCC | 6.49e-06 | 1.52e-01 | 0.1055 |
89782 | LMLN | P28T-E | Human | Esophagus | ESCC | 9.74e-10 | 2.16e-01 | 0.1149 |
89782 | LMLN | P30T-E | Human | Esophagus | ESCC | 1.70e-03 | 1.57e-01 | 0.137 |
89782 | LMLN | P32T-E | Human | Esophagus | ESCC | 6.19e-11 | 2.11e-01 | 0.1666 |
89782 | LMLN | P36T-E | Human | Esophagus | ESCC | 2.17e-06 | 2.37e-01 | 0.1187 |
89782 | LMLN | P37T-E | Human | Esophagus | ESCC | 7.63e-07 | 1.56e-01 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LMLN | SNV | Missense_Mutation | novel | c.2059C>A | p.Leu687Ile | p.L687I | Q96KR4 | protein_coding | tolerated_low_confidence(0.11) | possibly_damaging(0.78) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LMLN | SNV | Missense_Mutation | novel | c.1794N>C | p.Lys598Asn | p.K598N | Q96KR4 | protein_coding | tolerated(0.35) | benign(0.076) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LMLN | SNV | Missense_Mutation | novel | c.896N>A | p.Arg299Lys | p.R299K | Q96KR4 | protein_coding | deleterious(0.03) | probably_damaging(0.995) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
LMLN | SNV | Missense_Mutation | novel | c.2057N>G | p.Phe686Cys | p.F686C | Q96KR4 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.606) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LMLN | deletion | Frame_Shift_Del | novel | c.1661delN | p.Lys555SerfsTer9 | p.K555Sfs*9 | Q96KR4 | protein_coding | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
LMLN | SNV | Missense_Mutation | novel | c.2035C>G | p.Leu679Val | p.L679V | Q96KR4 | protein_coding | tolerated_low_confidence(0.11) | probably_damaging(0.986) | TCGA-2Y-A9H0-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
LMLN | SNV | Missense_Mutation | c.74N>T | p.Gly25Val | p.G25V | Q96KR4 | protein_coding | deleterious_low_confidence(0.01) | benign(0) | TCGA-CC-A7IG-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
LMLN | SNV | Missense_Mutation | rs781075916 | c.188N>T | p.Pro63Leu | p.P63L | Q96KR4 | protein_coding | tolerated(0.07) | benign(0.207) | TCGA-97-7546-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Targeted Molecular therapy | tarceva | SD |
LMLN | SNV | Missense_Mutation | novel | c.158N>G | p.Ser53Cys | p.S53C | Q96KR4 | protein_coding | tolerated_low_confidence(0.06) | possibly_damaging(0.713) | TCGA-18-4083-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
LMLN | SNV | Missense_Mutation | c.1863G>A | p.Met621Ile | p.M621I | Q96KR4 | protein_coding | tolerated(0.28) | benign(0.007) | TCGA-39-5037-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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