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Gene: LIPH |
Gene summary for LIPH |
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Gene information | Species | Human | Gene symbol | LIPH | Gene ID | 200879 |
Gene name | lipase H | |
Gene Alias | AH | |
Cytomap | 3q27.2 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | Q8WWY8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
200879 | LIPH | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.80e-02 | -3.81e-01 | 0.0155 |
200879 | LIPH | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.10e-02 | 4.05e-01 | -0.1808 |
200879 | LIPH | HTA11_347_2000001011 | Human | Colorectum | AD | 1.04e-15 | 6.53e-01 | -0.1954 |
200879 | LIPH | HTA11_411_2000001011 | Human | Colorectum | SER | 1.48e-04 | 1.09e+00 | -0.2602 |
200879 | LIPH | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.64e-04 | 8.83e-01 | -0.2196 |
200879 | LIPH | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.61e-04 | -2.62e-01 | 0.294 |
200879 | LIPH | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.65e-08 | -4.15e-01 | 0.3005 |
200879 | LIPH | A002-C-010 | Human | Colorectum | FAP | 1.41e-03 | -2.28e-01 | 0.242 |
200879 | LIPH | A015-C-203 | Human | Colorectum | FAP | 2.96e-16 | -3.16e-01 | -0.1294 |
200879 | LIPH | A015-C-204 | Human | Colorectum | FAP | 4.73e-02 | -2.76e-01 | -0.0228 |
200879 | LIPH | A002-C-201 | Human | Colorectum | FAP | 6.01e-08 | -3.97e-01 | 0.0324 |
200879 | LIPH | A002-C-203 | Human | Colorectum | FAP | 2.69e-03 | -2.10e-01 | 0.2786 |
200879 | LIPH | A001-C-119 | Human | Colorectum | FAP | 2.76e-03 | -1.33e-01 | -0.1557 |
200879 | LIPH | A001-C-108 | Human | Colorectum | FAP | 7.00e-08 | -1.58e-01 | -0.0272 |
200879 | LIPH | A002-C-205 | Human | Colorectum | FAP | 7.97e-11 | -3.33e-01 | -0.1236 |
200879 | LIPH | A015-C-006 | Human | Colorectum | FAP | 5.43e-09 | -4.62e-01 | -0.0994 |
200879 | LIPH | A015-C-106 | Human | Colorectum | FAP | 1.64e-07 | -2.10e-01 | -0.0511 |
200879 | LIPH | A002-C-114 | Human | Colorectum | FAP | 6.89e-07 | -3.12e-01 | -0.1561 |
200879 | LIPH | A015-C-104 | Human | Colorectum | FAP | 1.14e-19 | -3.85e-01 | -0.1899 |
200879 | LIPH | A001-C-014 | Human | Colorectum | FAP | 1.18e-04 | -2.03e-01 | 0.0135 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016042 | Colorectum | AD | lipid catabolic process | 97/3918 | 320/18723 | 4.31e-05 | 7.56e-04 | 97 |
GO:0006631 | Colorectum | AD | fatty acid metabolic process | 114/3918 | 390/18723 | 5.58e-05 | 9.44e-04 | 114 |
GO:0044242 | Colorectum | AD | cellular lipid catabolic process | 66/3918 | 214/18723 | 3.96e-04 | 4.50e-03 | 66 |
GO:0006650 | Colorectum | AD | glycerophospholipid metabolic process | 83/3918 | 306/18723 | 5.40e-03 | 3.55e-02 | 83 |
GO:0006644 | Colorectum | AD | phospholipid metabolic process | 101/3918 | 383/18723 | 5.80e-03 | 3.67e-02 | 101 |
GO:0045017 | Colorectum | AD | glycerolipid biosynthetic process | 69/3918 | 252/18723 | 8.33e-03 | 4.88e-02 | 69 |
GO:00160421 | Colorectum | SER | lipid catabolic process | 77/2897 | 320/18723 | 3.52e-05 | 9.18e-04 | 77 |
GO:00442421 | Colorectum | SER | cellular lipid catabolic process | 51/2897 | 214/18723 | 8.60e-04 | 1.05e-02 | 51 |
GO:0046486 | Colorectum | SER | glycerolipid metabolic process | 82/2897 | 392/18723 | 2.26e-03 | 2.17e-02 | 82 |
GO:00066441 | Colorectum | SER | phospholipid metabolic process | 79/2897 | 383/18723 | 3.94e-03 | 3.24e-02 | 79 |
GO:00450171 | Colorectum | SER | glycerolipid biosynthetic process | 55/2897 | 252/18723 | 4.47e-03 | 3.56e-02 | 55 |
GO:00066311 | Colorectum | SER | fatty acid metabolic process | 79/2897 | 390/18723 | 6.34e-03 | 4.56e-02 | 79 |
GO:00066501 | Colorectum | SER | glycerophospholipid metabolic process | 64/2897 | 306/18723 | 6.41e-03 | 4.60e-02 | 64 |
GO:00066312 | Colorectum | MSS | fatty acid metabolic process | 95/3467 | 390/18723 | 2.20e-03 | 1.84e-02 | 95 |
GO:0046394 | Colorectum | MSS | carboxylic acid biosynthetic process | 76/3467 | 314/18723 | 6.71e-03 | 4.38e-02 | 76 |
GO:00160422 | Colorectum | MSS | lipid catabolic process | 77/3467 | 320/18723 | 7.43e-03 | 4.71e-02 | 77 |
GO:0016053 | Colorectum | MSS | organic acid biosynthetic process | 76/3467 | 316/18723 | 7.88e-03 | 4.84e-02 | 76 |
GO:00066313 | Colorectum | FAP | fatty acid metabolic process | 81/2622 | 390/18723 | 1.43e-04 | 2.24e-03 | 81 |
GO:00442422 | Colorectum | FAP | cellular lipid catabolic process | 49/2622 | 214/18723 | 2.87e-04 | 3.77e-03 | 49 |
GO:0008654 | Colorectum | FAP | phospholipid biosynthetic process | 54/2622 | 253/18723 | 8.88e-04 | 9.08e-03 | 54 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LIPH | SNV | Missense_Mutation | rs762643917 | c.1217N>G | p.Tyr406Cys | p.Y406C | Q8WWY8 | protein_coding | tolerated(0.31) | benign(0.007) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
LIPH | SNV | Missense_Mutation | novel | c.317N>C | p.Val106Ala | p.V106A | Q8WWY8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
LIPH | SNV | Missense_Mutation | novel | c.207N>T | p.Lys69Asn | p.K69N | Q8WWY8 | protein_coding | tolerated(0.05) | possibly_damaging(0.461) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LIPH | SNV | Missense_Mutation | c.958N>T | p.Thr320Ser | p.T320S | Q8WWY8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DD-A73A-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LIPH | SNV | Missense_Mutation | novel | c.482N>A | p.Gly161Glu | p.G161E | Q8WWY8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-64-5774-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
LIPH | SNV | Missense_Mutation | novel | c.653N>T | p.Gly218Val | p.G218V | Q8WWY8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
LIPH | SNV | Missense_Mutation | c.836N>T | p.Gly279Val | p.G279V | Q8WWY8 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-39-5024-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | SD | |
LIPH | SNV | Missense_Mutation | novel | c.748N>T | p.Arg250Trp | p.R250W | Q8WWY8 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-43-8116-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
LIPH | SNV | Missense_Mutation | c.1055N>C | p.Arg352Thr | p.R352T | Q8WWY8 | protein_coding | tolerated(0.46) | benign(0.001) | TCGA-66-2768-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
LIPH | SNV | Missense_Mutation | novel | c.1266N>T | p.Glu422Asp | p.E422D | Q8WWY8 | protein_coding | tolerated(0.2) | benign(0.011) | TCGA-85-6561-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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