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Gene: LINS1 |
Gene summary for LINS1 |
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Gene information | Species | Human | Gene symbol | LINS1 | Gene ID | 55180 |
Gene name | lines homolog 1 | |
Gene Alias | LINS | |
Cytomap | 15q26.3 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q8NG48 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55180 | LINS1 | LZE4T | Human | Esophagus | ESCC | 2.42e-04 | 1.01e-01 | 0.0811 |
55180 | LINS1 | LZE7T | Human | Esophagus | ESCC | 5.83e-06 | 2.33e-01 | 0.0667 |
55180 | LINS1 | LZE8T | Human | Esophagus | ESCC | 4.81e-03 | 9.35e-02 | 0.067 |
55180 | LINS1 | LZE24T | Human | Esophagus | ESCC | 3.58e-04 | 1.34e-01 | 0.0596 |
55180 | LINS1 | LZE6T | Human | Esophagus | ESCC | 2.14e-03 | 2.45e-01 | 0.0845 |
55180 | LINS1 | P2T-E | Human | Esophagus | ESCC | 1.55e-13 | 1.97e-01 | 0.1177 |
55180 | LINS1 | P4T-E | Human | Esophagus | ESCC | 4.14e-11 | 2.10e-01 | 0.1323 |
55180 | LINS1 | P5T-E | Human | Esophagus | ESCC | 6.25e-22 | 2.22e-01 | 0.1327 |
55180 | LINS1 | P8T-E | Human | Esophagus | ESCC | 9.34e-13 | 2.68e-01 | 0.0889 |
55180 | LINS1 | P9T-E | Human | Esophagus | ESCC | 1.52e-10 | 2.51e-01 | 0.1131 |
55180 | LINS1 | P10T-E | Human | Esophagus | ESCC | 3.14e-18 | 2.35e-01 | 0.116 |
55180 | LINS1 | P11T-E | Human | Esophagus | ESCC | 1.66e-05 | 1.57e-01 | 0.1426 |
55180 | LINS1 | P12T-E | Human | Esophagus | ESCC | 5.62e-14 | 2.71e-01 | 0.1122 |
55180 | LINS1 | P15T-E | Human | Esophagus | ESCC | 5.56e-15 | 2.54e-01 | 0.1149 |
55180 | LINS1 | P16T-E | Human | Esophagus | ESCC | 5.47e-26 | 3.68e-01 | 0.1153 |
55180 | LINS1 | P17T-E | Human | Esophagus | ESCC | 1.48e-04 | 2.93e-01 | 0.1278 |
55180 | LINS1 | P19T-E | Human | Esophagus | ESCC | 2.34e-03 | 3.25e-01 | 0.1662 |
55180 | LINS1 | P20T-E | Human | Esophagus | ESCC | 4.46e-08 | 2.17e-01 | 0.1124 |
55180 | LINS1 | P21T-E | Human | Esophagus | ESCC | 1.01e-16 | 1.91e-01 | 0.1617 |
55180 | LINS1 | P22T-E | Human | Esophagus | ESCC | 2.15e-13 | 1.71e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LINS1 | SNV | Missense_Mutation | novel | c.821N>T | p.Arg274Met | p.R274M | Q8NG48 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LINS1 | SNV | Missense_Mutation | c.776N>C | p.Leu259Pro | p.L259P | Q8NG48 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LINS1 | SNV | Missense_Mutation | c.664N>G | p.Thr222Ala | p.T222A | Q8NG48 | protein_coding | tolerated(0.86) | benign(0.001) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LINS1 | SNV | Missense_Mutation | novel | c.610N>A | p.Asp204Asn | p.D204N | Q8NG48 | protein_coding | deleterious(0.03) | probably_damaging(0.995) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LINS1 | SNV | Missense_Mutation | novel | c.2039N>A | p.Arg680Lys | p.R680K | Q8NG48 | protein_coding | tolerated(1) | benign(0.083) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LINS1 | SNV | Missense_Mutation | rs376417416 | c.1040N>T | p.Ser347Leu | p.S347L | Q8NG48 | protein_coding | tolerated(1) | benign(0) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
LINS1 | SNV | Missense_Mutation | c.637N>A | p.Leu213Ile | p.L213I | Q8NG48 | protein_coding | deleterious(0.03) | possibly_damaging(0.799) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
LINS1 | SNV | Missense_Mutation | c.231N>T | p.Lys77Asn | p.K77N | Q8NG48 | protein_coding | tolerated(0.7) | benign(0.022) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
LINS1 | SNV | Missense_Mutation | rs376417416 | c.1040N>T | p.Ser347Leu | p.S347L | Q8NG48 | protein_coding | tolerated(1) | benign(0) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LINS1 | SNV | Missense_Mutation | c.271C>A | p.Leu91Ile | p.L91I | Q8NG48 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D1-A17D-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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