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Gene: KRT75 |
Gene summary for KRT75 |
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Gene information | Species | Human | Gene symbol | KRT75 | Gene ID | 9119 |
Gene name | keratin 75 | |
Gene Alias | CK-75 | |
Cytomap | 12q13.13 | |
Gene Type | protein-coding | GO ID | GO:0002244 | UniProtAcc | O95678 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9119 | KRT75 | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.49e-04 | 1.51e-01 | -0.0811 |
9119 | KRT75 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.07e-04 | 1.55e-01 | -0.1464 |
9119 | KRT75 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.47e-06 | 1.69e-01 | -0.059 |
9119 | KRT75 | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.48e-10 | 3.00e-01 | 0.0588 |
9119 | KRT75 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.04e-05 | 1.12e-01 | 0.294 |
9119 | KRT75 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.82e-03 | 1.18e-01 | 0.3859 |
9119 | KRT75 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.62e-04 | 1.21e-01 | 0.3005 |
9119 | KRT75 | P10T-E | Human | Esophagus | ESCC | 5.00e-17 | 5.31e-01 | 0.116 |
9119 | KRT75 | P11T-E | Human | Esophagus | ESCC | 3.25e-05 | 3.22e-01 | 0.1426 |
9119 | KRT75 | P19T-E | Human | Esophagus | ESCC | 7.48e-03 | 4.05e-01 | 0.1662 |
9119 | KRT75 | P21T-E | Human | Esophagus | ESCC | 4.17e-05 | 3.77e-01 | 0.1617 |
9119 | KRT75 | P22T-E | Human | Esophagus | ESCC | 4.44e-08 | 2.80e-01 | 0.1236 |
9119 | KRT75 | P24T-E | Human | Esophagus | ESCC | 1.66e-02 | 2.04e-01 | 0.1287 |
9119 | KRT75 | P31T-E | Human | Esophagus | ESCC | 6.89e-44 | 1.69e+00 | 0.1251 |
9119 | KRT75 | P37T-E | Human | Esophagus | ESCC | 6.65e-04 | 1.69e-01 | 0.1371 |
9119 | KRT75 | P42T-E | Human | Esophagus | ESCC | 3.05e-02 | 2.42e-01 | 0.1175 |
9119 | KRT75 | P52T-E | Human | Esophagus | ESCC | 7.98e-13 | 6.18e-01 | 0.1555 |
9119 | KRT75 | P61T-E | Human | Esophagus | ESCC | 2.42e-03 | 2.39e-01 | 0.099 |
9119 | KRT75 | P76T-E | Human | Esophagus | ESCC | 8.84e-05 | 2.77e-01 | 0.1207 |
9119 | KRT75 | P80T-E | Human | Esophagus | ESCC | 8.76e-16 | 1.28e+00 | 0.155 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0002244 | Colorectum | MSS | hematopoietic progenitor cell differentiation | 32/3467 | 114/18723 | 8.07e-03 | 4.91e-02 | 32 |
GO:00022446 | Esophagus | ESCC | hematopoietic progenitor cell differentiation | 66/8552 | 114/18723 | 5.74e-03 | 2.13e-02 | 66 |
GO:00022445 | Oral cavity | OSCC | hematopoietic progenitor cell differentiation | 57/7305 | 114/18723 | 1.09e-02 | 3.71e-02 | 57 |
GO:000224413 | Skin | cSCC | hematopoietic progenitor cell differentiation | 42/4864 | 114/18723 | 6.74e-03 | 3.27e-02 | 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KRT75 | SNV | Missense_Mutation | novel | c.1277A>G | p.Asp426Gly | p.D426G | O95678 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
KRT75 | SNV | Missense_Mutation | novel | c.32C>T | p.Ser11Phe | p.S11F | O95678 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
KRT75 | SNV | Missense_Mutation | novel | c.1117N>G | p.Met373Val | p.M373V | O95678 | protein_coding | tolerated(0.28) | benign(0.009) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KRT75 | SNV | Missense_Mutation | c.1299G>T | p.Glu433Asp | p.E433D | O95678 | protein_coding | tolerated(0.24) | possibly_damaging(0.464) | TCGA-BC-A10Z-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KRT75 | deletion | Frame_Shift_Del | novel | c.674delT | p.Leu225ArgfsTer30 | p.L225Rfs*30 | O95678 | protein_coding | TCGA-G3-AAV0-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
KRT75 | SNV | Missense_Mutation | novel | c.1044N>C | p.Glu348Asp | p.E348D | O95678 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-05-4432-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
KRT75 | SNV | Missense_Mutation | novel | c.1464C>A | p.Ser488Arg | p.S488R | O95678 | protein_coding | tolerated(0.33) | benign(0.052) | TCGA-38-4631-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
KRT75 | SNV | Missense_Mutation | novel | c.122N>A | p.Ala41Glu | p.A41E | O95678 | protein_coding | tolerated(0.29) | benign(0.033) | TCGA-44-4112-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
KRT75 | SNV | Missense_Mutation | c.838G>A | p.Glu280Lys | p.E280K | O95678 | protein_coding | deleterious(0.01) | probably_damaging(0.954) | TCGA-67-6217-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Targeted Molecular therapy | tarceva | SD | |
KRT75 | SNV | Missense_Mutation | c.209G>T | p.Arg70Leu | p.R70L | O95678 | protein_coding | deleterious(0.01) | possibly_damaging(0.566) | TCGA-69-7765-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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