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Gene: KLF3 |
Gene summary for KLF3 |
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Gene information | Species | Human | Gene symbol | KLF3 | Gene ID | 51274 |
Gene name | Kruppel like factor 3 | |
Gene Alias | BKLF | |
Cytomap | 4p14 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A0A024R9T8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51274 | KLF3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.95e-08 | -4.48e-01 | 0.0155 |
51274 | KLF3 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.26e-08 | 5.42e-01 | -0.1954 |
51274 | KLF3 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.49e-03 | 9.36e-01 | -0.2602 |
51274 | KLF3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.44e-05 | -3.26e-01 | 0.3005 |
51274 | KLF3 | A015-C-203 | Human | Colorectum | FAP | 1.06e-23 | -3.81e-01 | -0.1294 |
51274 | KLF3 | A015-C-204 | Human | Colorectum | FAP | 4.96e-04 | -2.67e-01 | -0.0228 |
51274 | KLF3 | A002-C-201 | Human | Colorectum | FAP | 5.45e-07 | -2.50e-01 | 0.0324 |
51274 | KLF3 | A001-C-119 | Human | Colorectum | FAP | 9.37e-04 | -3.58e-01 | -0.1557 |
51274 | KLF3 | A001-C-108 | Human | Colorectum | FAP | 3.52e-07 | -2.09e-01 | -0.0272 |
51274 | KLF3 | A002-C-205 | Human | Colorectum | FAP | 1.26e-15 | -3.83e-01 | -0.1236 |
51274 | KLF3 | A015-C-006 | Human | Colorectum | FAP | 6.04e-10 | -3.17e-01 | -0.0994 |
51274 | KLF3 | A015-C-106 | Human | Colorectum | FAP | 1.48e-03 | -1.70e-01 | -0.0511 |
51274 | KLF3 | A002-C-114 | Human | Colorectum | FAP | 3.76e-14 | -3.73e-01 | -0.1561 |
51274 | KLF3 | A015-C-104 | Human | Colorectum | FAP | 6.08e-22 | -3.49e-01 | -0.1899 |
51274 | KLF3 | A001-C-014 | Human | Colorectum | FAP | 1.53e-11 | -3.05e-01 | 0.0135 |
51274 | KLF3 | A002-C-016 | Human | Colorectum | FAP | 2.93e-15 | -3.88e-01 | 0.0521 |
51274 | KLF3 | A015-C-002 | Human | Colorectum | FAP | 3.41e-09 | -4.41e-01 | -0.0763 |
51274 | KLF3 | A001-C-203 | Human | Colorectum | FAP | 8.60e-04 | -1.79e-01 | -0.0481 |
51274 | KLF3 | A002-C-116 | Human | Colorectum | FAP | 1.43e-25 | -4.34e-01 | -0.0452 |
51274 | KLF3 | A014-C-008 | Human | Colorectum | FAP | 2.03e-10 | -4.03e-01 | -0.191 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:19016531 | Colorectum | SER | cellular response to peptide | 83/2897 | 359/18723 | 8.03e-05 | 1.77e-03 | 83 |
GO:19016532 | Colorectum | MSS | cellular response to peptide | 91/3467 | 359/18723 | 7.38e-04 | 7.88e-03 | 91 |
GO:19016533 | Colorectum | FAP | cellular response to peptide | 89/2622 | 359/18723 | 2.93e-08 | 2.64e-06 | 89 |
GO:19016534 | Colorectum | CRC | cellular response to peptide | 64/2078 | 359/18723 | 8.54e-05 | 1.75e-03 | 64 |
GO:190165319 | Esophagus | ESCC | cellular response to peptide | 208/8552 | 359/18723 | 1.68e-06 | 2.01e-05 | 208 |
GO:190165311 | Liver | Cirrhotic | cellular response to peptide | 129/4634 | 359/18723 | 1.23e-06 | 2.49e-05 | 129 |
GO:190165321 | Liver | HCC | cellular response to peptide | 211/7958 | 359/18723 | 2.86e-10 | 9.63e-09 | 211 |
GO:190165316 | Oral cavity | OSCC | cellular response to peptide | 194/7305 | 359/18723 | 4.31e-09 | 9.57e-08 | 194 |
GO:190165317 | Oral cavity | LP | cellular response to peptide | 122/4623 | 359/18723 | 4.22e-05 | 6.10e-04 | 122 |
GO:190165323 | Oral cavity | EOLP | cellular response to peptide | 85/2218 | 359/18723 | 2.06e-10 | 2.06e-08 | 85 |
GO:190165310 | Prostate | BPH | cellular response to peptide | 104/3107 | 359/18723 | 2.51e-09 | 1.00e-07 | 104 |
GO:190165315 | Prostate | Tumor | cellular response to peptide | 104/3246 | 359/18723 | 2.71e-08 | 8.90e-07 | 104 |
GO:190165320 | Skin | AK | cellular response to peptide | 61/1910 | 359/18723 | 4.60e-05 | 7.21e-04 | 61 |
GO:1901653110 | Skin | cSCC | cellular response to peptide | 124/4864 | 359/18723 | 1.75e-04 | 1.49e-03 | 124 |
GO:1901653111 | Thyroid | PTC | cellular response to peptide | 169/5968 | 359/18723 | 9.81e-10 | 2.89e-08 | 169 |
GO:190165325 | Thyroid | ATC | cellular response to peptide | 173/6293 | 359/18723 | 5.87e-09 | 1.28e-07 | 173 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05202 | Colorectum | FAP | Transcriptional misregulation in cancer | 45/1404 | 193/8465 | 9.19e-03 | 3.33e-02 | 2.03e-02 | 45 |
hsa052021 | Colorectum | FAP | Transcriptional misregulation in cancer | 45/1404 | 193/8465 | 9.19e-03 | 3.33e-02 | 2.03e-02 | 45 |
hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0520213 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa052027 | Prostate | BPH | Transcriptional misregulation in cancer | 53/1718 | 193/8465 | 9.56e-03 | 2.92e-02 | 1.81e-02 | 53 |
hsa0520212 | Prostate | BPH | Transcriptional misregulation in cancer | 53/1718 | 193/8465 | 9.56e-03 | 2.92e-02 | 1.81e-02 | 53 |
hsa0520221 | Prostate | Tumor | Transcriptional misregulation in cancer | 59/1791 | 193/8465 | 1.22e-03 | 5.26e-03 | 3.26e-03 | 59 |
hsa0520231 | Prostate | Tumor | Transcriptional misregulation in cancer | 59/1791 | 193/8465 | 1.22e-03 | 5.26e-03 | 3.26e-03 | 59 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLF3 | SNV | Missense_Mutation | c.922N>G | p.Thr308Ala | p.T308A | P57682 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-BR-6566-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KLF3 | SNV | Missense_Mutation | rs761105610 | c.707N>T | p.Ser236Leu | p.S236L | P57682 | protein_coding | tolerated(0.09) | probably_damaging(0.953) | TCGA-BR-7707-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KLF3 | SNV | Missense_Mutation | c.397C>T | p.Arg133Trp | p.R133W | P57682 | protein_coding | deleterious(0.05) | possibly_damaging(0.725) | TCGA-BR-8682-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
KLF3 | SNV | Missense_Mutation | c.908G>A | p.Arg303Gln | p.R303Q | P57682 | protein_coding | deleterious(0) | benign(0) | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD | |
KLF3 | SNV | Missense_Mutation | c.4N>A | p.Leu2Ile | p.L2I | P57682 | protein_coding | deleterious(0) | benign(0.003) | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD | |
KLF3 | SNV | Missense_Mutation | rs761153626 | c.266N>A | p.Arg89Gln | p.R89Q | P57682 | protein_coding | tolerated(0.61) | possibly_damaging(0.625) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
KLF3 | SNV | Missense_Mutation | novel | c.308N>T | p.Pro103Leu | p.P103L | P57682 | protein_coding | tolerated(0.05) | possibly_damaging(0.446) | TCGA-MX-A663-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KLF3 | SNV | Missense_Mutation | rs761224497 | c.646T>C | p.Ser216Pro | p.S216P | P57682 | protein_coding | tolerated(0.28) | probably_damaging(0.91) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
KLF3 | insertion | Frame_Shift_Ins | novel | c.677dupC | p.Gln227AlafsTer37 | p.Q227Afs*37 | P57682 | protein_coding | TCGA-BR-4280-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
KLF3 | deletion | Frame_Shift_Del | c.312delN | p.Lys106AsnfsTer21 | p.K106Nfs*21 | P57682 | protein_coding | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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