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Gene: KLF12 |
Gene summary for KLF12 |
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Gene information | Species | Human | Gene symbol | KLF12 | Gene ID | 11278 |
Gene name | Kruppel like factor 12 | |
Gene Alias | AP-2rep | |
Cytomap | 13q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q8WWI3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11278 | KLF12 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.96e-06 | -4.10e-01 | 0.0155 |
11278 | KLF12 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.46e-02 | -2.80e-01 | -0.1464 |
11278 | KLF12 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.99e-07 | -4.71e-01 | 0.096 |
11278 | KLF12 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.25e-03 | -1.84e-01 | 0.294 |
11278 | KLF12 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.94e-05 | -4.11e-01 | 0.3859 |
11278 | KLF12 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.91e-05 | -5.81e-01 | 0.2585 |
11278 | KLF12 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.01e-07 | -3.73e-01 | 0.3005 |
11278 | KLF12 | A015-C-203 | Human | Colorectum | FAP | 7.32e-15 | -3.26e-01 | -0.1294 |
11278 | KLF12 | A015-C-204 | Human | Colorectum | FAP | 2.26e-02 | -2.41e-01 | -0.0228 |
11278 | KLF12 | A014-C-040 | Human | Colorectum | FAP | 2.49e-02 | -4.18e-01 | -0.1184 |
11278 | KLF12 | A002-C-201 | Human | Colorectum | FAP | 1.23e-10 | -3.88e-01 | 0.0324 |
11278 | KLF12 | A001-C-108 | Human | Colorectum | FAP | 1.45e-05 | -2.37e-01 | -0.0272 |
11278 | KLF12 | A002-C-205 | Human | Colorectum | FAP | 1.13e-15 | -4.54e-01 | -0.1236 |
11278 | KLF12 | A015-C-005 | Human | Colorectum | FAP | 1.50e-02 | -2.76e-01 | -0.0336 |
11278 | KLF12 | A015-C-006 | Human | Colorectum | FAP | 3.30e-12 | -5.33e-01 | -0.0994 |
11278 | KLF12 | A015-C-106 | Human | Colorectum | FAP | 1.34e-04 | -1.82e-01 | -0.0511 |
11278 | KLF12 | A002-C-114 | Human | Colorectum | FAP | 6.53e-12 | -4.20e-01 | -0.1561 |
11278 | KLF12 | A015-C-104 | Human | Colorectum | FAP | 8.34e-18 | -4.34e-01 | -0.1899 |
11278 | KLF12 | A001-C-014 | Human | Colorectum | FAP | 6.80e-05 | -2.24e-01 | 0.0135 |
11278 | KLF12 | A002-C-016 | Human | Colorectum | FAP | 1.26e-12 | -3.22e-01 | 0.0521 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 2 3 4 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLF12 | SNV | Missense_Mutation | novel | c.838G>A | p.Gly280Ser | p.G280S | Q9Y4X4 | protein_coding | tolerated(0.21) | benign(0.003) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
KLF12 | SNV | Missense_Mutation | novel | c.275C>T | p.Ser92Phe | p.S92F | Q9Y4X4 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
KLF12 | SNV | Missense_Mutation | novel | c.240N>C | p.Glu80Asp | p.E80D | Q9Y4X4 | protein_coding | deleterious(0.04) | possibly_damaging(0.899) | TCGA-37-A5EN-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
KLF12 | SNV | Missense_Mutation | c.283N>C | p.Ala95Pro | p.A95P | Q9Y4X4 | protein_coding | tolerated(0.2) | benign(0.094) | TCGA-66-2770-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KLF12 | SNV | Missense_Mutation | novel | c.249N>A | p.Asp83Glu | p.D83E | Q9Y4X4 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-98-8022-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KLF12 | SNV | Missense_Mutation | novel | c.406N>A | p.Ala136Thr | p.A136T | Q9Y4X4 | protein_coding | tolerated(0.59) | benign(0) | TCGA-NC-A5HI-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
KLF12 | SNV | Missense_Mutation | novel | c.60N>T | p.Met20Ile | p.M20I | Q9Y4X4 | protein_coding | deleterious_low_confidence(0.02) | benign(0.38) | TCGA-NK-A5CT-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KLF12 | SNV | Missense_Mutation | novel | c.611N>C | p.Gly204Ala | p.G204A | Q9Y4X4 | protein_coding | tolerated(0.07) | benign(0.096) | TCGA-CQ-5332-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
KLF12 | SNV | Missense_Mutation | novel | c.560C>T | p.Pro187Leu | p.P187L | Q9Y4X4 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-D6-6516-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KLF12 | SNV | Missense_Mutation | novel | c.1118N>T | p.Gly373Val | p.G373V | Q9Y4X4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EJ-7312-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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