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Gene: KIF22 |
Gene summary for KIF22 |
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Gene information | Species | Human | Gene symbol | KIF22 | Gene ID | 3835 |
Gene name | kinesin family member 22 | |
Gene Alias | A-328A3.2 | |
Cytomap | 16p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | A0A024R632 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3835 | KIF22 | GSM4909290 | Human | Breast | IDC | 1.28e-09 | 4.00e-01 | 0.2096 |
3835 | KIF22 | GSM4909291 | Human | Breast | IDC | 9.01e-08 | 3.94e-01 | 0.1753 |
3835 | KIF22 | GSM4909293 | Human | Breast | IDC | 2.13e-15 | 4.48e-01 | 0.1581 |
3835 | KIF22 | GSM4909294 | Human | Breast | IDC | 1.77e-02 | 2.31e-01 | 0.2022 |
3835 | KIF22 | GSM4909296 | Human | Breast | IDC | 4.51e-05 | 2.96e-01 | 0.1524 |
3835 | KIF22 | GSM4909301 | Human | Breast | IDC | 4.90e-27 | 7.12e-01 | 0.1577 |
3835 | KIF22 | GSM4909304 | Human | Breast | IDC | 3.99e-33 | 6.54e-01 | 0.1636 |
3835 | KIF22 | GSM4909306 | Human | Breast | IDC | 5.94e-49 | 9.21e-01 | 0.1564 |
3835 | KIF22 | GSM4909307 | Human | Breast | IDC | 2.53e-03 | 2.97e-01 | 0.1569 |
3835 | KIF22 | GSM4909311 | Human | Breast | IDC | 9.05e-12 | 1.41e-01 | 0.1534 |
3835 | KIF22 | GSM4909313 | Human | Breast | IDC | 2.04e-03 | 2.08e-01 | 0.0391 |
3835 | KIF22 | GSM4909317 | Human | Breast | IDC | 2.37e-02 | 2.17e-01 | 0.1355 |
3835 | KIF22 | GSM4909319 | Human | Breast | IDC | 3.44e-10 | 1.49e-01 | 0.1563 |
3835 | KIF22 | GSM4909321 | Human | Breast | IDC | 1.52e-05 | 2.60e-01 | 0.1559 |
3835 | KIF22 | M2 | Human | Breast | IDC | 4.12e-03 | 3.30e-01 | 0.21 |
3835 | KIF22 | DCIS2 | Human | Breast | DCIS | 4.18e-27 | 7.54e-02 | 0.0085 |
3835 | KIF22 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.48e-11 | 3.15e-01 | -0.1954 |
3835 | KIF22 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.10e-08 | 3.41e-01 | -0.1464 |
3835 | KIF22 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.52e-03 | 2.28e-01 | -0.059 |
3835 | KIF22 | LZE4T | Human | Esophagus | ESCC | 1.56e-04 | 2.66e-01 | 0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0007062 | Colorectum | AD | sister chromatid cohesion | 23/3918 | 62/18723 | 2.51e-03 | 1.92e-02 | 23 |
GO:0140014 | Colorectum | AD | mitotic nuclear division | 78/3918 | 287/18723 | 6.48e-03 | 4.05e-02 | 78 |
GO:005165616 | Esophagus | HGIN | establishment of organelle localization | 90/2587 | 390/18723 | 4.27e-07 | 1.94e-05 | 90 |
GO:00500003 | Esophagus | HGIN | chromosome localization | 24/2587 | 82/18723 | 2.07e-04 | 3.82e-03 | 24 |
GO:01400146 | Esophagus | HGIN | mitotic nuclear division | 61/2587 | 287/18723 | 3.38e-04 | 5.55e-03 | 61 |
GO:00070593 | Esophagus | HGIN | chromosome segregation | 71/2587 | 346/18723 | 3.47e-04 | 5.62e-03 | 71 |
GO:00513033 | Esophagus | HGIN | establishment of chromosome localization | 23/2587 | 80/18723 | 3.71e-04 | 5.77e-03 | 23 |
GO:00070803 | Esophagus | HGIN | mitotic metaphase plate congression | 15/2587 | 50/18723 | 2.35e-03 | 2.39e-02 | 15 |
GO:00513103 | Esophagus | HGIN | metaphase plate congression | 18/2587 | 65/18723 | 2.46e-03 | 2.45e-02 | 18 |
GO:00000703 | Esophagus | HGIN | mitotic sister chromatid segregation | 36/2587 | 168/18723 | 4.42e-03 | 3.87e-02 | 36 |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:005131011 | Esophagus | ESCC | metaphase plate congression | 58/8552 | 65/18723 | 1.81e-13 | 8.63e-12 | 58 |
GO:000708011 | Esophagus | ESCC | mitotic metaphase plate congression | 47/8552 | 50/18723 | 3.15e-13 | 1.47e-11 | 47 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00988133 | Esophagus | ESCC | nuclear chromosome segregation | 187/8552 | 281/18723 | 1.00e-12 | 4.36e-11 | 187 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIF22 | SNV | Missense_Mutation | rs752878228 | c.1875N>A | p.His625Gln | p.H625Q | Q14807 | protein_coding | tolerated(0.06) | probably_damaging(0.95) | TCGA-DD-A11C-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KIF22 | SNV | Missense_Mutation | novel | c.1606C>G | p.Leu536Val | p.L536V | Q14807 | protein_coding | tolerated(0.85) | benign(0.012) | TCGA-DD-A3A7-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Chemotherapy | unknown | PD |
KIF22 | SNV | Missense_Mutation | novel | c.1832N>T | p.Gly611Val | p.G611V | Q14807 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DD-AAE6-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
KIF22 | SNV | Missense_Mutation | novel | c.1765C>A | p.Arg589Ser | p.R589S | Q14807 | protein_coding | deleterious(0.02) | benign(0.445) | TCGA-DD-AAEG-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIF22 | SNV | Missense_Mutation | c.1948A>C | p.Lys650Gln | p.K650Q | Q14807 | protein_coding | deleterious(0.04) | possibly_damaging(0.877) | TCGA-44-A47A-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KIF22 | SNV | Missense_Mutation | c.1003N>T | p.Gly335Cys | p.G335C | Q14807 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-50-6594-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
KIF22 | SNV | Missense_Mutation | c.760N>C | p.Val254Leu | p.V254L | Q14807 | protein_coding | deleterious(0) | benign(0.306) | TCGA-34-2600-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIF22 | SNV | Missense_Mutation | c.593N>T | p.Arg198Leu | p.R198L | Q14807 | protein_coding | deleterious(0) | possibly_damaging(0.758) | TCGA-85-6561-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD | |
KIF22 | SNV | Missense_Mutation | novel | c.1126N>A | p.Glu376Lys | p.E376K | Q14807 | protein_coding | tolerated(0.08) | benign(0.202) | TCGA-CN-4734-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KIF22 | SNV | Missense_Mutation | c.604N>T | p.Arg202Trp | p.R202W | Q14807 | protein_coding | tolerated(0.05) | benign(0.006) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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