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Gene: KIF1BP |
Gene summary for KIF1BP |
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Gene information | Species | Human | Gene symbol | KIF1BP | Gene ID | 26128 |
Gene name | kinesin family binding protein | |
Gene Alias | KBP | |
Cytomap | 10q22.1 | |
Gene Type | protein-coding | GO ID | GO:0001701 | UniProtAcc | Q96EK5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26128 | KIF1BP | LZE4T | Human | Esophagus | ESCC | 4.64e-11 | 2.54e-01 | 0.0811 |
26128 | KIF1BP | LZE24T | Human | Esophagus | ESCC | 5.96e-11 | 2.28e-01 | 0.0596 |
26128 | KIF1BP | P2T-E | Human | Esophagus | ESCC | 1.59e-19 | 2.67e-01 | 0.1177 |
26128 | KIF1BP | P4T-E | Human | Esophagus | ESCC | 8.51e-19 | 3.52e-01 | 0.1323 |
26128 | KIF1BP | P5T-E | Human | Esophagus | ESCC | 3.13e-08 | 1.89e-01 | 0.1327 |
26128 | KIF1BP | P8T-E | Human | Esophagus | ESCC | 1.22e-10 | 1.73e-01 | 0.0889 |
26128 | KIF1BP | P9T-E | Human | Esophagus | ESCC | 6.92e-11 | 9.90e-02 | 0.1131 |
26128 | KIF1BP | P10T-E | Human | Esophagus | ESCC | 8.06e-12 | 7.60e-02 | 0.116 |
26128 | KIF1BP | P11T-E | Human | Esophagus | ESCC | 2.85e-09 | 3.26e-01 | 0.1426 |
26128 | KIF1BP | P12T-E | Human | Esophagus | ESCC | 4.77e-18 | 3.33e-01 | 0.1122 |
26128 | KIF1BP | P15T-E | Human | Esophagus | ESCC | 9.58e-17 | 2.26e-01 | 0.1149 |
26128 | KIF1BP | P16T-E | Human | Esophagus | ESCC | 8.13e-16 | 2.09e-01 | 0.1153 |
26128 | KIF1BP | P17T-E | Human | Esophagus | ESCC | 4.24e-04 | 1.27e-01 | 0.1278 |
26128 | KIF1BP | P20T-E | Human | Esophagus | ESCC | 2.06e-08 | 8.93e-02 | 0.1124 |
26128 | KIF1BP | P21T-E | Human | Esophagus | ESCC | 5.58e-14 | 2.31e-01 | 0.1617 |
26128 | KIF1BP | P22T-E | Human | Esophagus | ESCC | 7.03e-10 | 1.93e-01 | 0.1236 |
26128 | KIF1BP | P23T-E | Human | Esophagus | ESCC | 2.18e-15 | 2.40e-01 | 0.108 |
26128 | KIF1BP | P24T-E | Human | Esophagus | ESCC | 4.38e-19 | 3.53e-01 | 0.1287 |
26128 | KIF1BP | P26T-E | Human | Esophagus | ESCC | 1.32e-17 | 3.01e-01 | 0.1276 |
26128 | KIF1BP | P27T-E | Human | Esophagus | ESCC | 1.81e-14 | 2.72e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIF1BP | insertion | Frame_Shift_Ins | rs781469363 | c.1508_1509insA | p.Ile506AsnfsTer3 | p.I506Nfs*3 | Q96EK5 | protein_coding | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
KIF1BP | insertion | Nonsense_Mutation | novel | c.1524_1525insGGTTAAGTAGGACACTCA | p.Asn508_Leu509insGlyTerValGlyHisSer | p.N508_L509insG*VGHS | Q96EK5 | protein_coding | TCGA-BG-A0MU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Hormone Therapy | megace | SD | ||
KIF1BP | insertion | Frame_Shift_Ins | rs769950460 | c.1077_1078insA | p.Ala362SerfsTer8 | p.A362Sfs*8 | Q96EK5 | protein_coding | TCGA-BK-A0C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
KIF1BP | insertion | Nonsense_Mutation | novel | c.1524_1525insGGTTAAGTAGGACACTCACCTCCTG | p.Leu509GlyfsTer2 | p.L509Gfs*2 | Q96EK5 | protein_coding | TCGA-D1-A0ZZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | SD | ||
KIF1BP | insertion | Frame_Shift_Ins | rs781469363 | c.1508_1509insA | p.Ile506AsnfsTer3 | p.I506Nfs*3 | Q96EK5 | protein_coding | TCGA-DF-A2KY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | ||
KIF1BP | SNV | Missense_Mutation | novel | c.1124N>T | p.Ser375Phe | p.S375F | Q96EK5 | protein_coding | deleterious(0.04) | benign(0.326) | TCGA-MR-A520-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KIF1BP | SNV | Missense_Mutation | c.1809G>T | p.Met603Ile | p.M603I | Q96EK5 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-73-4659-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | alimta | PD | |
KIF1BP | SNV | Missense_Mutation | rs770724316 | c.1117G>A | p.Ala373Thr | p.A373T | Q96EK5 | protein_coding | tolerated(0.29) | possibly_damaging(0.492) | TCGA-18-3406-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KIF1BP | SNV | Missense_Mutation | c.1646N>T | p.Arg549Leu | p.R549L | Q96EK5 | protein_coding | tolerated(0.19) | benign(0.259) | TCGA-22-4613-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIF1BP | SNV | Missense_Mutation | rs762099157 | c.1452G>A | p.Met484Ile | p.M484I | Q96EK5 | protein_coding | tolerated(0.07) | probably_damaging(0.99) | TCGA-33-AASL-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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