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Gene: KIAA2026 |
Gene summary for KIAA2026 |
Gene summary. |
Gene information | Species | Human | Gene symbol | KIAA2026 | Gene ID | 158358 |
Gene name | KIAA2026 | |
Gene Alias | KIAA2026 | |
Cytomap | 9p24.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q5HYC2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
158358 | KIAA2026 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.98e-25 | -6.81e-01 | 0.0155 |
158358 | KIAA2026 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.18e-02 | -3.61e-01 | -0.1808 |
158358 | KIAA2026 | HTA11_2951_2000001011 | Human | Colorectum | AD | 7.33e-03 | -6.86e-01 | 0.0216 |
158358 | KIAA2026 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.62e-11 | -6.84e-01 | -0.1207 |
158358 | KIAA2026 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.24e-02 | -3.24e-01 | -0.1526 |
158358 | KIAA2026 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.69e-12 | -4.54e-01 | -0.1464 |
158358 | KIAA2026 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.85e-09 | -4.59e-01 | -0.1001 |
158358 | KIAA2026 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.08e-06 | -3.85e-01 | -0.059 |
158358 | KIAA2026 | HTA11_5216_2000001011 | Human | Colorectum | SER | 7.95e-03 | -5.19e-01 | -0.1462 |
158358 | KIAA2026 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.14e-04 | -4.80e-01 | -0.0842 |
158358 | KIAA2026 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.32e-02 | -5.70e-01 | -0.0179 |
158358 | KIAA2026 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.47e-18 | -6.69e-01 | 0.096 |
158358 | KIAA2026 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.44e-03 | -5.82e-01 | 0.0528 |
158358 | KIAA2026 | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.88e-02 | -6.39e-01 | 0.0171 |
158358 | KIAA2026 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.25e-08 | -5.97e-01 | 0.0338 |
158358 | KIAA2026 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.45e-13 | -5.10e-01 | 0.0674 |
158358 | KIAA2026 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.35e-07 | -5.00e-01 | 0.0588 |
158358 | KIAA2026 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.96e-15 | -4.54e-01 | 0.294 |
158358 | KIAA2026 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.69e-09 | -4.35e-01 | 0.3859 |
158358 | KIAA2026 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.67e-08 | -6.67e-01 | 0.2585 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA2026 | SNV | Missense_Mutation | novel | c.2605G>T | p.Asp869Tyr | p.D869Y | Q5HYC2 | protein_coding | deleterious(0) | possibly_damaging(0.542) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIAA2026 | SNV | Missense_Mutation | rs756863980 | c.979G>A | p.Glu327Lys | p.E327K | Q5HYC2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIAA2026 | SNV | Missense_Mutation | c.6037C>A | p.Leu2013Ile | p.L2013I | Q5HYC2 | protein_coding | tolerated(0.25) | benign(0.003) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KIAA2026 | SNV | Missense_Mutation | novel | c.5171T>G | p.Ile1724Ser | p.I1724S | Q5HYC2 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KIAA2026 | SNV | Missense_Mutation | c.4208C>A | p.Ser1403Tyr | p.S1403Y | Q5HYC2 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
KIAA2026 | SNV | Missense_Mutation | rs754732111 | c.4241N>T | p.Ser1414Leu | p.S1414L | Q5HYC2 | protein_coding | tolerated(0.08) | benign(0.005) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KIAA2026 | SNV | Missense_Mutation | c.4240T>C | p.Ser1414Pro | p.S1414P | Q5HYC2 | protein_coding | tolerated(0.43) | benign(0.003) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
KIAA2026 | SNV | Missense_Mutation | novel | c.2026A>G | p.Lys676Glu | p.K676E | Q5HYC2 | protein_coding | deleterious(0.04) | benign(0.013) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
KIAA2026 | SNV | Missense_Mutation | novel | c.233A>C | p.Glu78Ala | p.E78A | Q5HYC2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
KIAA2026 | SNV | Missense_Mutation | rs199581068 | c.5294N>T | p.Ser1765Leu | p.S1765L | Q5HYC2 | protein_coding | tolerated(1) | benign(0) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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