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Gene: KIAA1958 |
Gene summary for KIAA1958 |
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Gene information | Species | Human | Gene symbol | KIAA1958 | Gene ID | 158405 |
Gene name | KIAA1958 | |
Gene Alias | KIAA1958 | |
Cytomap | 9q32 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q8N8K9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
158405 | KIAA1958 | CCI_1 | Human | Cervix | CC | 7.04e-05 | 5.03e-01 | 0.528 |
158405 | KIAA1958 | CCI_2 | Human | Cervix | CC | 2.77e-08 | 6.53e-01 | 0.5249 |
158405 | KIAA1958 | CCI_3 | Human | Cervix | CC | 6.45e-11 | 6.76e-01 | 0.516 |
158405 | KIAA1958 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.45e-06 | -3.60e-01 | 0.0155 |
158405 | KIAA1958 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.99e-03 | -3.10e-01 | -0.1001 |
158405 | KIAA1958 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.66e-04 | -3.58e-01 | 0.0674 |
158405 | KIAA1958 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.11e-02 | 8.16e-01 | 0.3487 |
158405 | KIAA1958 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.36e-07 | -3.14e-01 | 0.3005 |
158405 | KIAA1958 | A001-C-207 | Human | Colorectum | FAP | 4.08e-04 | -3.46e-01 | 0.1278 |
158405 | KIAA1958 | A015-C-203 | Human | Colorectum | FAP | 1.03e-18 | -4.39e-01 | -0.1294 |
158405 | KIAA1958 | A015-C-204 | Human | Colorectum | FAP | 4.52e-06 | -4.09e-01 | -0.0228 |
158405 | KIAA1958 | A014-C-040 | Human | Colorectum | FAP | 3.21e-03 | -4.97e-01 | -0.1184 |
158405 | KIAA1958 | A002-C-201 | Human | Colorectum | FAP | 3.27e-10 | -4.08e-01 | 0.0324 |
158405 | KIAA1958 | A002-C-203 | Human | Colorectum | FAP | 2.81e-03 | -2.62e-01 | 0.2786 |
158405 | KIAA1958 | A001-C-119 | Human | Colorectum | FAP | 2.60e-04 | -3.93e-01 | -0.1557 |
158405 | KIAA1958 | A001-C-108 | Human | Colorectum | FAP | 3.95e-13 | -3.77e-01 | -0.0272 |
158405 | KIAA1958 | A002-C-205 | Human | Colorectum | FAP | 1.83e-15 | -4.65e-01 | -0.1236 |
158405 | KIAA1958 | A001-C-104 | Human | Colorectum | FAP | 1.04e-03 | -3.38e-01 | 0.0184 |
158405 | KIAA1958 | A015-C-005 | Human | Colorectum | FAP | 2.10e-06 | -4.41e-01 | -0.0336 |
158405 | KIAA1958 | A015-C-006 | Human | Colorectum | FAP | 5.52e-10 | -4.45e-01 | -0.0994 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA1958 | SNV | Missense_Mutation | c.1884N>A | p.Ser628Arg | p.S628R | Q8N8K9 | protein_coding | tolerated(0.33) | benign(0.402) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
KIAA1958 | SNV | Missense_Mutation | novel | c.1232N>T | p.Thr411Met | p.T411M | Q8N8K9 | protein_coding | deleterious(0) | possibly_damaging(0.761) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIAA1958 | SNV | Missense_Mutation | rs761336625 | c.2186N>T | p.Ser729Leu | p.S729L | Q8N8K9 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIAA1958 | SNV | Missense_Mutation | rs768342901 | c.1363N>A | p.Ala455Thr | p.A455T | Q8N8K9 | protein_coding | tolerated(0.18) | probably_damaging(0.986) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIAA1958 | SNV | Missense_Mutation | novel | c.796C>A | p.Pro266Thr | p.P266T | Q8N8K9 | protein_coding | tolerated_low_confidence(0.14) | benign(0) | TCGA-EY-A549-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIAA1958 | SNV | Missense_Mutation | novel | c.2068N>T | p.Asp690Tyr | p.D690Y | Q8N8K9 | protein_coding | tolerated(1) | possibly_damaging(0.574) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
KIAA1958 | SNV | Missense_Mutation | c.2218N>A | p.His740Asn | p.H740N | Q8N8K9 | protein_coding | tolerated_low_confidence(0.07) | benign(0.099) | TCGA-FI-A2EW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatinum | PD | |
KIAA1958 | insertion | Nonsense_Mutation | novel | c.469_470insTATGAAGAC | p.Asp157delinsValTerArgHis | p.D157delinsV*RH | Q8N8K9 | protein_coding | TCGA-A5-A0R9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
KIAA1958 | insertion | Nonsense_Mutation | novel | c.469_470insTATGAAGACA | p.Asp157ValfsTer2 | p.D157Vfs*2 | Q8N8K9 | protein_coding | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
KIAA1958 | SNV | Missense_Mutation | c.1657N>A | p.Ala553Thr | p.A553T | Q8N8K9 | protein_coding | tolerated(0.44) | benign(0.06) | TCGA-CC-A7II-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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